The products of the action of thrombin on fibrinogen

Building better fibrin knob mimics: an investigation of synthetic fibrin knob peptide structures in solution and their dynamic binding with fibrinogen/fibrin holes

“…This process is initiated by the activated serine protease thrombin, which specifically cleaves 4 N-terminal arginyl-glycine motifs on the 2 adjacent A␣ and B␤ chains of fibrinogen, releasing 2 sets of fibrinopeptides A and B (FpA and FpB) and exposing cryptic fibrin polymerization knobs "A" and "B," respectively. [1][2][3][4][5] The newly exposed fibrin knobs noncovalently interact with complementary "holes"' within the 2 distal C-terminal regions of the ␥ and ␤ chains (complementary holes "a" and "b," respectively) to initiate fibrin protofibril assembly. Understanding the fundamentals of this dynamic and noncovalent knob:hole interaction will lead to both a more thorough understanding of fibrin assembly mechanisms and the establishment of design criteria for superior anticoagulants with high polymerization hole affinity to inhibit fibrin assembly.…”

Sol Sherry Lecture in Thrombosis

“…The dramatic conversion of fibrinogen to fibrin is caused by the proteolytic action of thrombin with the release of N-terminal fibrinopeptide moieties [5][6][7][8] (Figure 2a). These "caps" have to be removed from the protein for unmasking the self-assembly potential that was built into the parent fibrinogen molecule by evolution.…”

Quelques Techniques Nouvelles Pour L'Etude De La Structure Des Proteines

“…(estomae (135,78.159) gene (29) (29) (pancreas de (pancrbaa P.M. 25.000 P.M. 15.000 P.M. 34.500 P.M. 14.700 Pepsine (29) Lysoryme boeuf) de boeuf) de boeuf) (oeuf de poule) …”

“…Au lieu de faire apparaitre, comme celle du chymotrypoinoghe, de nouvelles chahes ouvertes, elle provoque vraisemblablement le depart d'au moins un peptide N-terminal (188a).La coagulation du fibrinoghne (thrombine) fait apparaftre de l'azote non-prot6ique(143,143a). Quatre peptides prennent vraisemblablement naissance(15). Deux possedent l'acide glutamique N-terminal perdu par le fibrinoghne.…”