2022
DOI: 10.3390/jcm11216421
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The Profile and Clinical Significance of ITGB2 Expression in Non-Small-Cell Lung Cancer

Abstract: Integrins are involved in extracellular and intracellular signaling and are often aberrantly expressed in tumors. Integrin beta 2 (ITGB2) has previously been demonstrated to be correlated with the host defense. However, the expression profile and role of ITGB2 in non-small-cell lung cancer (NSCLC) remain unclear. Here, we found that the genetic alterations in ITGB2 was predominated by gene mutation and copy number deletion using cBioPortal analysis, and its expression was downregulated in the NSCLC tissues, as… Show more

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Cited by 15 publications
(5 citation statements)
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“…It inhibited the proliferation and metastasis of NSCLC cells through suppressing EMT. Furthermore, low expression of it was associated with inferior prognosis in NSCLC (67), which was validated in an independent dataset, GSE68465 (Figure 3G).…”
Section: B C D E F G Amentioning
confidence: 61%
“…It inhibited the proliferation and metastasis of NSCLC cells through suppressing EMT. Furthermore, low expression of it was associated with inferior prognosis in NSCLC (67), which was validated in an independent dataset, GSE68465 (Figure 3G).…”
Section: B C D E F G Amentioning
confidence: 61%
“…These ndings suggest that ITGB2 plays an important role in tumor development. Studies have demonstrated that overexpression of ITGB2 can increase its expression level In H1792 cells, ITGB2 can reduce the expression levels of N -cadherin, Vimentin, Slug, Snail and Twist, suggesting that ITGB2 can affect the growth of NSCLC cells by inhibiting the EMT pathway [35].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, there is a growing consensus that EMT is essential for the development of DN (33,34). And ITGB2 is also closely related to the regulation of EMT (35,36).…”
Section: Discussionmentioning
confidence: 99%