The profile and outcome of pustular psoriasis in Singapore: a report of 28 cases

Tay, Yong–Kwang; Tham, S N

doi:10.1046/j.1365-4362.1997.00170.x

Cited by 43 publications

(72 citation statements)

References 16 publications

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“…Its appearance is of an expanse of small, monomorphic pustules, often involving the edges of expanding, intensely inflammatory plaques or developing within erythrodermic skin (2).…”

Section: Discussionmentioning

confidence: 99%

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Long‐term efficacy of adalimumab in generalized pustular psoriasis

Zangrilli

Papoutsaki

Talamonti

et al. 2008

Journal of Dermatological Treatment

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“…Its appearance is of an expanse of small, monomorphic pustules, often involving the edges of expanding, intensely inflammatory plaques or developing within erythrodermic skin (2).…”

Section: Discussionmentioning

confidence: 99%

“…The disease is characterized by an eruption of superficial and small sterile pustules, followed by the generalized development of erythematous lesions (2). The prevalence is relatively high among men aged between 60 and 65 years (3).…”

Section: Introductionmentioning

confidence: 99%

Long‐term efficacy of adalimumab in generalized pustular psoriasis

Zangrilli

Papoutsaki

Talamonti

et al. 2008

Journal of Dermatological Treatment

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“…On the other hand, MTX administration shows good results in psoriasis and BP overlap conditions. Localized GPP demonstrate an excellent response to MTX treatment, while other GPP demonstrate a moderate-to-good response [10]. In this patient, it was astonishing to see how the bullo-pustular lesions disappeared following treatment with two doses of MTX 10 mg/week.…”

Section: Discussionmentioning

confidence: 96%

Pemphigoid Diseases as a Sign of Active Psoriasis: A Case Report and Brief Review

et al. 2015

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Background: Overlap of bullous pemphigoid (BP) with chronic psoriatic plaques (CPP) is a common condition. However, the association of BP with pustular psoriasis (PP) is uncommon. Moreover, perilesional erythema and pustular lesions on CPP are accepted as a sign of unstable psoriasis. Unstable psoriasis could be triggered by certain irritant topical treatments against psoriasis. These chemical agents could also induce a localized pattern of generalized PP. Here, we describe BP and PP collision in unstable CPP. Objective: By this observation we suggest that BP could be a sign of active psoriasis. Presumably, psoriasis-induced BP is an inflammation activity-dependent condition. Methods: This study is a case report and literature review. Results: The dramatic response of bullo-pustular lesions to short-term methotrexate (MTX) treatment suggests the rule of ‘no psoriasis, no BP'. Presumably, MTX supressed the active inflammation of CPP and BP disappeared following CPP control. Conclusion: BP can be a sign of active psoriasis in the present case.

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“…Neutrophils play an important role in the formation of the acute inflammatory changes in psoriasis, while chronic inflammation is well explained by a T cell-associated inflammation-sustaining loop 6. Treatment of acute inflammation or acute flares in psoriasis is an unmet medical need 4,5,7,8. The p38 mitogen-activated protein kinase (MAPK) signaling pathway is active in inflammatory skin diseases9–11 and inhibitors of this pathway reduce skin inflammation in various rodent models of human skin diseases 12,13.…”

Section: Introductionmentioning

confidence: 99%

Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig

Satyanarayana¹

2010

JIR

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Certain skin pathologies, including psoriasis, are thought to be immune-mediated inflammatory diseases. Available literature clearly indicates the involvement of inflammatory cells (neutrophils, T cells, and macrophages), their cytokines, and the p38 mitogen-activated protein kinase (MAPK) signaling pathway in the pathophysiology of psoriasis. Neutrophils play an important role in the formation of acute inflammatory changes in psoriasis. Acute inflammation or acute flares in psoriasis remain poorly addressed in clinical medicine. In this communication, we first establish a simple and reproducible model for studying neutrophil-mediated acute skin inflammation. Using the hairless guinea pig, due to the similarity of skin architecture to that of human, acute inflammation was induced with an intradermal injection of 50 μg/mL lipopolysaccharide (LPS) in 50 μL solution. Myeloperoxidase (MPO) activity was measured by MPO-positive neutrophils and shown to increase for 24-hours post-injection. Simultaneously, the level of phosphorylated p38 MAPK was documented for 48-hours post-LPS injection in the skin. Next, we used this model to examine the therapeutic potential of an α-selective p38 MAPK inhibitor, SCIO-469. A comparison of topical application of SCIO-469 at 5 mg/mL or 15 mg/mL to vehicle revealed that SCIO-469 dose-dependently reduces acute skin inflammation and that this effect is statistically significant at the higher dose. Further examination of tissues that received this dose also revealed statistically significant reduction of MPO activity, phosphorylated p38 MAPK, interleukin-6, and cyclooxygenase-2. These data suggest that the α-selective p38 MAPK inhibitor, SCIO-469, acts as a topical anti-inflammatory agent via the p38 MAPK pathway to reduce neutrophil induced acute inflammation in the skin. These observations suggest that α-selective p38 MAPK inhibition may be an effective therapeutic strategy to manage acute skin inflammation

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The profile and outcome of pustular psoriasis in Singapore: a report of 28 cases

Abstract: The pattern of pustular psoriasis seen in Singapore is similar to that reported in the Western literature. Using these categories we can provide guidelines for treatment and prognosis.

Cited by 43 publications

References 16 publications

Long‐term efficacy of adalimumab in generalized pustular psoriasis

Long‐term efficacy of adalimumab in generalized pustular psoriasis

Pemphigoid Diseases as a Sign of Active Psoriasis: A Case Report and Brief Review

Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig

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