The profile of adsorbed plasma and serum proteins on methacrylic acid copolymer beads: Effect on complement activation

Wells, Laura; Guo, Hongbo; Emili, Andrew; Sefton, Michael V.

doi:10.1016/j.biomaterials.2016.11.036

Cited by 34 publications

(30 citation statements)

References 44 publications

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“…The first event that happens when biomaterials come in contact with blood is the adsorption of blood plasma proteins, which mediate subsequent biological phenomena, such as the attachment of platelets and other blood cells to the surface (Xu, Bauer, & Siedlecki, ). Among the blood proteins that adsorb, fibrinogen plays a central role in the coagulation cascade and is primarily responsible for platelet adhesion (Wells, Guo, Emili, & Sefton, ). The blood clotting induced by biomaterial surfaces occurs primarily by the intrinsic pathway of the coagulation cascade (Yan, Xu, Vogler, & Siedlecki, ).…”

Section: Discussionmentioning

confidence: 99%

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

Sabino

Kauk

Madruga

et al. 2020

J Biomedical Materials Res

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Biomaterial-associated thrombus formation and bacterial infection remain major challenges for blood-contacting devices. For decades, titanium-based implants have been largely used for different medical applications. However, titanium can neither suppress blood coagulation, nor prevent bacterial infections. To address these challenges, tanfloc/heparin polyelectrolyte multilayers on titania nanotubes array surfaces (NT) were developed. The surfaces were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle measurements. To evaluate the hemocompatibility of the surfaces, fibrinogen adsorption, Factor XII activation, and platelet adhesion and activation were analyzed.The antibacterial activity was investigated against Gram-negative P. aeruginosa and Gram-positive S. aureus. Bacterial adhesion and morphology, as well as biofilm formation, were analyzed using fluorescence microscopy and SEM. The anti-thrombogenic properties of the surfaces were demonstrated by significant decreases in fibrinogen adsorption, Factor XII activation, and platelet adhesion and activation. Modifying NT with tanfloc/heparin also reduces the adhesion and proliferation of P. aeruginosa and S. aureus bacteria after 24 hr of incubation, with no biofilm formation. The modified NT surfaces with tanfloc/heparin polyelectrolyte multilayers are a promising biomaterial for use on implant surfaces because of their enhanced blood biocompatibility and antibacterial properties.

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Section: Discussionmentioning

confidence: 99%

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

Sabino

Kauk

Madruga

et al. 2020

J Biomedical Materials Res

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“…When biomaterials are implanted into the body, the injury causes blood and body fluids to inevitably contact the surface of implants, and nonspecific adsorption of plasma proteins occurs within seconds, [ 118 ] which is an early‐stage event associated with subsequent inflammation and wound healing process. [ 119 ] The amount and type of adsorbed proteins on the surface of the implanted material depend on the material surface itself, and the composition and structure of the adsorbed protein largely determine the recognition and activation of immune cells, which in turn trigger complex immune responses and promote the FBR. [ 120,121 ] For example, fibrinogen can induce inflammation by recognizing with the phagocyte intergrin, Mac‐1 (CD11b/CD18).…”

Section: The Mechanism Of Foreign‐body Responsementioning

confidence: 99%

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang

Chen

Shi

et al. 2020

Adv Funct Materials

176

139

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Foreign‐body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to the development of implantable biomaterials and medical devices. Recent advances in implantable biomaterials and medical devices have provided strategies to resist the foreign‐body response. In this review, the mechanism of the foreign‐body response and conventional strategies to mitigate foreign‐body response is briefly introduced. Then, three types of promising foreign‐body response resisting materials are focused and the advantages, characteristics, and applications of each material are discussed. Finally, prospects are put forward for future development of foreign‐body response resisting materials and current challenges that require in‐depth study.

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“…In the presence of an implant, part of this neo-ECM adsorbs to the material surface as a 2–5 nm thick layer of provisional ECM [ 43 , 44 , 45 ] ( Figure 1 ). In the FBR and during normal wound healing, the provisional ECM provides a structural cell-populated scaffold that stores and continuously releases various mitogens, chemo-attractants, cytokines, and growth factors, all influencing the outcome of the FBR [ 2 , 46 ]. In both cases, hemostasis is followed by and overlaps with a phase of acute inflammation that ranges from hours to few days and usually resolves within one week [ 7 ].…”

Section: Commonalities Between the Fbr And Normal Wound Healingmentioning

confidence: 99%

“…For example, mass spectrometry analysis of proteins adsorbed at the surface of polyethylene glycol (PEG)-based hydrogels identified more than 200 different adsorbed proteins most of which are associated with wound healing and acute inflammation [ 64 ]. Protein coverage and cell interactions with the surface both determine the ability of cells to attach and spread on implants [ 46 , 64 ]. Therefore, modulating implant surface properties is a common strategy to enhance tissue integration while simultaneously reducing the incidence and severity of implant FBR and fibrosis.…”

Section: What Is Different Between Normal Wound Healing and The Fbr? The Implantmentioning

confidence: 99%

Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction

Noskovičová

Hinz

Pakshir

2021

Cells

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Body implants and implantable medical devices have dramatically improved and prolonged the life of countless patients. However, our body repair mechanisms have evolved to isolate, reject, or destroy any object that is recognized as foreign to the organism and inevitably mounts a foreign body reaction (FBR). Depending on its severity and chronicity, the FBR can impair implant performance or create severe clinical complications that will require surgical removal and/or replacement of the faulty device. The number of review articles discussing the FBR seems to be proportional to the number of different implant materials and clinical applications and one wonders, what else is there to tell? We will here take the position of a fibrosis researcher (which, coincidentally, we are) to elaborate similarities and differences between the FBR, normal wound healing, and chronic healing conditions that result in the development of peri-implant fibrosis. After giving credit to macrophages in the inflammatory phase of the FBR, we will mainly focus on the activation of fibroblastic cells into matrix-producing and highly contractile myofibroblasts. While fibrosis has been discussed to be a consequence of the disturbed and chronic inflammatory milieu in the FBR, direct activation of myofibroblasts at the implant surface is less commonly considered. Thus, we will provide a perspective how physical properties of the implant surface control myofibroblast actions and accumulation of stiff scar tissue. Because formation of scar tissue at the surface and around implant materials is a major reason for device failure and extraction surgeries, providing implant surfaces with myofibroblast-suppressing features is a first step to enhance implant acceptance and functional lifetime. Alternative therapeutic targets are elements of the myofibroblast mechanotransduction and contractile machinery and we will end with a brief overview on such targets that are considered for the treatment of other organ fibroses.

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The profile of adsorbed plasma and serum proteins on methacrylic acid copolymer beads: Effect on complement activation

Cited by 34 publications

References 44 publications

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction

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