The profile of adult onset <scp>H</scp>enoch–<scp>S</scp>chönlein purpura in an <scp>A</scp>sian population

Yong, Adeline Mei-Yen; Lee, Shan-Xian; Tay, Yong–Kwang

doi:10.1111/ijd.12732

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…The presence of ulcerative lesions has been reported by other groups evaluating only adult-onset IgAV, with frequencies between 13% and 35%. 28,32,33 These findings highlight that clinicians must consider IgAV in patients with ulcerative skin lesions, particularly if present in adults, and underscore the benefit of direct immunofluorescence, which would assist in the diagnosis of IgAV in such cases.…”

Section: Discussionmentioning

confidence: 90%

Clinical Characteristics of Biopsy-Proven IgA Vasculitis in Children and Adults: A Retrospective Cohort Study

Villatoro-Villar

Crowson

Warrington

et al. 2019

Mayo Clinic Proceedings

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Objective: To describe the differences in clinical characteristics and outcome between adult-and childhood-onset biopsy-proven IgA vasculitis (IgAV) in North America. Patients and Methods: Patients with IgAV diagnosed from January 1, 1997, through December 31, 2016, were retrospectively identified. Data were abstracted from direct medical record review. Kaplan-Meier methods were used to estimate survival rates. Results: A total of 243 patients with IgAV were included (227 [93.4%] white, 141 [58.0%] male); 174 patients were adults (!21 years), and 69 were younger than 21 years. Compared with patients younger than 21 years, adults at baseline more frequently had ulcerative skin lesions (19 [10.9%] vs 1 [1.4%]; P¼.02) and nephrotic-range proteinuria (21 of 96 [21.9%] vs 1 of 38 [2.6%]; P¼.007) but less commonly had abdominal pain (59 [33.9%] vs 42 [60.9%]; P<.001), ischemic gastrointestinal tract involvement (18 [10.3%] vs 14 [20.3%]; P¼.04), and arthralgias (66 [37.9%] vs 42 [60.8%]; P<.001). During 389 person-years of follow-up, 29 deaths were observed. Five-year survival rates for patients aged younger than 21, 21 to 50, and 51 years or older were 100%, 94%, and 40%, respectively. In comparison to data from the United States life tables for whites, patients 51 years or older at diagnosis had a greater than 7-fold increased risk of mortality (standardized mortality, 7.60 [95% CI, 5.01-11.06]; P<.001). Conclusion: IgA vasculitis in adults is associated with more severe skin/kidney involvement and poorer renal outcome. Among adults with IgAV, patients aged 51 years or older at diagnosis have significantly higher mortality (P<.001).

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Section: Discussionmentioning

confidence: 90%

Clinical Characteristics of Biopsy-Proven IgA Vasculitis in Children and Adults: A Retrospective Cohort Study

Villatoro-Villar

Crowson

Warrington

et al. 2019

Mayo Clinic Proceedings

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“…It is currently known that the accepted classification criteria of the European League Against Rheumatism (EULAR) to establish the diagnosis require the presence of purpura and at least one of the following four clinical aspects: abdominal pain, arthritis, renal involvement, or biopsy histology reflecting leukocytoclastic vasculitis or IgA deposition. Nevertheless, it is necessary to understand that this classification has not been validated or designed for application in adult populations (YONG;LEE;TAY, 2015). Interestingly, the patient in this case presented, in addition to the lesions in the form of purpura, renal involvement on the urinalysis performed after her admission to the hospital, demonstrating the following findings: the presence of deposits; of positive nitrite; of present proteins; microscopic hematuria; considerable leukocyturia; intense bacterial flora; leukocyte casts; and presence of renal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

IgA VASCULITIS IN THE FORM OF CUTANEOUS PRESENTATION IN A 45-YEAR-OLD WOMAN TREATED WITH CORTICOSTEROID: CASE REPORT

Carvalho¹

2021

Rev. UNINGÁ

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mmunoglobulin A vasculitis (IgAV) is known to be a systemic vasculitis of small vessels. Although is possible that this condition sets up in any age group, the epidemiological profile of this disease mostly affects the pediatric population between 2 and 10 years of age. In this sense, this descriptive article aims to report the rare case of an adult patient who evolved with IgAV, presented in a cutaneous form, and treated with corticosteroids. For that, after the patient's free and informed consent, the study was approved by the Research Ethics Committee of the University of Rio Verde (UniRV, Goiás, Brazil), whose Certificate of Presentation for Ethical Consideration is 36621920.0.0000.507. Therefore, it was found that the patient evolved with clinical compatible with IgAV of probable cutaneous involvement due to lesions in the form of purpura and renal involvement, presenting a good therapeutic response with corticosteroid therapy at non-immunosuppressive doses and after 1 year and 3 months of follow-up, there was remission of the clinicalpicture without new episodes.There are some reports in the literature about the good therapeutic response of this clinical with corticosteroid therapy at non-immunosuppressive doses, however, clinical trials are needed.

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“…It is characterized by the association of skin, joints, and gastrointestinal manifestations that may occur in successive episodes [ 1 , 2 ]. In adults, the incidence of HSP is 1.3 per 100,000 population [ 3 ]. The clinical presentation of HSP is more severe among adults and tends to be atypical [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and management of Henoch-Schonlein purpura in Indonesian elderly with severe complication: A rare case

Putri

Awalia

2022

Annals of Medicine &Amp; Surgery

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The profile of adult onset Henoch–Schönlein purpura in an Asian population

Abstract: Our study confirms that HSP in adults tends to be more severe with a high incidence of extracutaneous manifestations, especially renal disease. Pyrexia at presentation and the presence of purpura were significant predictive factors for renal involvement.

Cited by 8 publications

References 20 publications

Clinical Characteristics of Biopsy-Proven IgA Vasculitis in Children and Adults: A Retrospective Cohort Study

Clinical Characteristics of Biopsy-Proven IgA Vasculitis in Children and Adults: A Retrospective Cohort Study

IgA VASCULITIS IN THE FORM OF CUTANEOUS PRESENTATION IN A 45-YEAR-OLD WOMAN TREATED WITH CORTICOSTEROID: CASE REPORT

Diagnosis and management of Henoch-Schonlein purpura in Indonesian elderly with severe complication: A rare case

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