The profile of infertility in a teaching Hospital in North West Nigeria

Panti, A; Sununu, Yusuf T

doi:10.4103/1118-8561.129145

Cited by 63 publications

(87 citation statements)

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“…Presentation after five years of marriage was seen in 53% of patients in study of Nigerian population. 12 The predominance of primary infertility (67.55%) in our study agrees with the pervious study of most western societies where primary infertility is seen in almost (61-70%) of cases and secondary infertility in 29-33% of patients. 13,14 Present study is in contrast with Panti AA et al study done in Nigeria where a total of 1,264 new gynecological cases were seen during the study period, and 198 infertile patients were evaluated.…”

Section: Discussionsupporting

confidence: 92%

“…Primary infertility constituted 32.8%, while secondary infertility was 67.2 %. 12 Male factor was responsible in 37.39%, female factor in 20.48%, unexplained in 22.46% while a combination of both factor was seen in 8.37% cases in our study while in study conducted by Chowdhary MA et al female accounted for 45.8%, male factor in 25.6%, unexplained…”

Section: Discussionsupporting

confidence: 46%

“…12 Both partners contributed to infertility in 16.7%, while no cause was found in 20.7% of patients.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of causes and clinical pattern of infertility in couples coming to a tertiary care centre in Bihar, India

Singh

Ranjan

Bharti

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Infertility is one of the major health problems and a socially destabilizing condition for couples often causing marital disharmony. Infertility is defined as the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Worldwide, its prevalence is approximately 8-12%.There are numerous factors such as anatomical, physiological and genetic factors that cause infertility. Many environmental and acquired factors also lead to inability to conceive. Objective of the present study was to determine the causes and clinical pattern of infertility in infertile couples.Methods: It was a hospital based observational study carried out on 750 women in reproductive age group attending out-patient clinic of Reproductive Biology Department of Indira Gandhi Institute of Medical Sciences (IGIMS) at Patna during April 2013 to March 2017. All the cases of primary and secondary infertility diagnosed after full examinations and laboratory tests were included and cases lacking of full examinations and laboratory tests were excluded. All the data of infertile couples were recorded in a semi-structured Case Information Performa.Results: Out of 750 women 454 women had all the data and they participated in the study Nearly 68% women had primary infertility and rest had secondary infertility. Male factor was responsible in 37.39%, female factor in 20.48%, unexplained in 22.46% while a combination of both factor was seen in 8.37% cases in our study .135 women had irregular menstrual cycles in which 64(47%) had oligomenohhrea. 79% women had normal ultrasonography and nearly 11% of women had evidence of PCOD. 24% women had hypothyroidism (TSH more than 4.5 IU/L) and 59(13%) were found to have high level of prolactin i.e. >25 ng/ml. Nearly 8% of women had high level of FSH i.e. more than 10 IU/L which is an indicator of ovarian resistance. In nearly 16% women one fallopian tube was found blocked and 8% had both tubes blocked in hysterosalpingography. Husband semen analysis was done to assess male factor. Nearly 14% of their male partners suffered from azoospermia and 23% had at least one abnormal parameter in semen analysis.Conclusions: Etiological pattern of infertility varies in different parts of World. Male and female factors both are responsible for infertility. So, both the partners should be counselled and investigated properly.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 46%

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Analysis of causes and clinical pattern of infertility in couples coming to a tertiary care centre in Bihar, India

Singh

Ranjan

Bharti

2017

Int J Reprod Contracept Obstet Gynecol

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“…22 Oxidative stress can have detrimental effects on female fertility by affecting ovulation, fertilization, embryo development and implantation. 23 Studies have shown high oxidative stress in PCOS women compared to control.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

Panti

Shehu

Saidu

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: PCOS is a condition with significant decrease in antioxidant with an increased risk of oxidative stress. Antioxidant supplementation has been shown to improve insulin sensitivity in PCOS and may improve outcome of management of PCOS. Objectives of this study were to determine the oxidative stress level of PCOS patients, to assess the effect of antioxidant supplementation on the outcome of management of PCOS and to compare with a control group.Methods: The study was a single blind randomised control trial involving 200 patients with PCOS. The study was conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. They were randomly divided into intervention and control groups and base line serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals were determined. Antioxidant supplementation and placebo were given to the intervention and control groups respectively. All the patients had ovulation induction with clomiphene citrate and were followed up for 6 months. Outcome measures were clinical pregnancy or menstrual regularisation. Level of significance was <0.05.Results: There was statistical significance in the serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals between the two groups (post intervention). Glutathione peroxidase (p = 0.001), superoxide dismutase (p = 0.0001), catalase (p= 0.0369), melondialdehyde (p= 0.007), Vitamin A, Vitamin C, Vitamin E (p = 0.0001), zinc and copper (p = 0.0001). The clinical pregnancy outcomes were 22 (22%) versus 2 (2%); live births 18 (18%) versus 2 (2%) and menstrual regularisation 48 (48%) versus 46 (46%) in the intervention and control groups respectively.Conclusions: Antioxidant supplementation in this study significantly affected pregnancy rate in patients with PCOS. Larger studies are suggested to revisit the conclusion of the Cochrane review that antioxidants supplementation had no significant role in female infertility.

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“…This was observed in this study where 65.1% had previously used traditional medications. 3 Subfertile couples consulting fertility clinics are commonly regarded as highly motivated to achieve conception 4 . Bangladesh is an economically constrain country; almost one third of our patients desiring children give only one visit where as one third of the patients complete investigation and confirm the cause of infertility and almost one third come for treatment.…”

Section: Discussionmentioning

confidence: 99%

Treatment Seeking Behavior and the Profile of Infertile Patients Attending the Tertiary Infertility Center at Dhaka

Fatima

Hossain

Rahman

et al. 2017

J. Bangladesh Coll. Phys.

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Background: Motherhood is an integral part of womanhood and being childless is a devastating experience for a woman in developing countries like Bangladesh. Majority of patients in developing countries have virtually no access to treatment. Few health facilities have provision for proper diagnosis and treatment for infertility. There is a general lack of awareness among the public regarding infertility. In the quest for conception, many couples adopt for alternative therapies and religious rituals killing crucial age and time.Objective: To find out the treatment seeking behavior and the profile of infertile patients attending a tertiary infertility center at Dhaka, Bangladesh . Results: Treatment seeking behavior of infertile patients attending Center for Assisted Reproduction, (CARe) Dhaka revealed 30% of the patients initially go to the traditional healers for the relief of infertility, 36% consult both traditional healers and doctors and 32% consulted with GP and Gynae specialist, and only 2% came straight to the tertiary center( CARe) for their subfertility. 55% of the patients attending the clinic were from urban area and 45% were from rural area. The maximum number of patients were from Dhaka division followed by Chittagong, Khulna, Barisal, Sylhet and Rajshahi. The overall primary and secondary infertility were in 63.34% and 36.66% of the patients respectively. 90% of the patients were Muslim and 9% were Hindu and 1% were from other religion. Only 32.37 % of the patients took treatment in the clinic for their infertility. Male factor problems as identified among the male partners of the infertile couples were azoospermia in 18%, abnormal semen parameter in 24%,and normal semen parameter in 58 %. Among the female partners completing investigations, 17% suffered from anovulation, 20% from premature ovarian failure and 3% from ovarian failure , with a total of 40% of the women suffering from ovarian factor, 8% suffered from endometriosis, 7% from bilateral tubal block, 3% from uterine factor problem. In 42% women there was no apparent cause in the females. Untreatable causes of infertility among the infertile couples were in 3.75% of the patients. Ovarian failure was in 3% cases, testicular failure in 0.5% and uterine factor in 0.25% of cases. 75% of the women were less than thirty five years of age where as 29 % of the males were less than 35 years. MethodsConclusion: Causes of infertility vary from region to region so also social and cultural conditions. Financial condition also affects the health seeking behavior of the patients. For the purpose of management of infertile couples the cause of infertility is important to understand so that the options of treatment and the prognosis can be discussed with the patients.

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The profile of infertility in a teaching Hospital in North West Nigeria

Cited by 63 publications

References 0 publications

Analysis of causes and clinical pattern of infertility in couples coming to a tertiary care centre in Bihar, India

Analysis of causes and clinical pattern of infertility in couples coming to a tertiary care centre in Bihar, India

Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

Treatment Seeking Behavior and the Profile of Infertile Patients Attending the Tertiary Infertility Center at Dhaka

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