The Prognosis of Depression in Old Age

Burvill, P. W.; Hall, Wayne; Stampfer, Hans G.; Emmerson, J P

doi:10.1192/bjp.158.1.64

Cited by 95 publications

(73 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In two further UK studies, of inpatients only, the figures were 53% (Post, 1972) and 44% (Baldwin and Jolley, 1986). In Australia, Burvill et al (1991) found that 35% of their depressed group, mainly inpatients, were deluded. In the USA, Meyers and Greenberg (1986) reported that 45% of their 161 patients, consecutively admitted, were deluded.…”

Section: Discussionmentioning

confidence: 93%

Delusional depression in elderly patients: Characteristics and relationship to age at onset

Baldwin

1995

Int J Geriat Psychiatry

View full text Add to dashboard Cite

SUMMARYIn a prospective study, 34 patients with delusional depression were compared with 100 non-psychotically depressed patients and a subgroup of 30 age-and sex-matched control patients. Depressed patients with delusions were more likely to be single, especially single men. The most common delusions were those of persecution and hypochondriasis. There were no striking differences in other depression symptoms and no evidence for the hypothesis that delusional depression is associated with a later age of depression onset. KEY womsdepression; delusions; psychotic; ageing; elderlyDelusional depression is a distinct subtype of major depression. In studies of mixed-aged or younger adults, compared with non-delusional depression there are differences in glucocorticoid and dopamine-P-hydroxylase activity, levels of dopamine and serotonin metabolites, sleep measures and ventricle-to-brain ratios (summarized by Schatzberg and Rothschild, 1992). Furthermore, the presence of delusions tends to run true through relapses of depression (Charney and Nelson, 1980).In an earlier study, I confirmed that a number of the above distinguishing features of delusional depression are valid for elderly patients (Baldwin, 1988). Nevertheless, delusional depression in older patients remains a relatively neglected area of research.There are clinical and theoretical reasons for studying delusional forms of depression as a separate entity. First, the treatment of the delusional variant of depressive illness differs from nondelusional depression (Baldwin, 1988). Second, Meyers and Greenberg (1986) found an increase in delusional forms of depression with increasing age at onset. In an elderly sample of 161 patients,

show abstract

Section: Discussionmentioning

confidence: 93%

Delusional depression in elderly patients: Characteristics and relationship to age at onset

Baldwin

1995

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

“…In all, 70-80% of the study participants responded to treatment (with about half ultimately remitting) but differed in how long they took to respond. Both the high rates of response and the similarity of categorical outcomes among the three groups may be attributable to the high-intensity, systematic treatment regimen (paroxetine, interpersonal psychotherapy, and drug augmentation, if appropriate), as also reported in a prior study (Burvill et al, 1991). Additionally, patients with recurrent depression (regardless of age of onset) were more likely to require at least one augmenting agent to achieve stabilization, thus accounting for their longer time to response (4 weeks on average).…”

Section: Treatment Response Variability (Table 2 Figure 1)mentioning

confidence: 84%

Late-onset major depression: clinical and treatment-response variability

Driscoll¹,

Basinski²,

Mulsant³

et al. 2005

Int. J. Geriat. Psychiatry

View full text Add to dashboard Cite

show abstract

“…It may, therefore, modify the otherwise unfavorable impact that chronic physical illnesses are known to have on the presentation and prognosis of depression (Murphy, 1983;Baldwin and Jolley, 1986;Burvill et al, 1991;Meats et al, 1991).…”

Section: Introductionmentioning

confidence: 98%