The Prognosis of Medulloblastoma in Children

Smith, Roger; Lampé, I; Kahn, Edgar A.

doi:10.3171/jns.1961.18.1.0091

Cited by 50 publications

(8 citation statements)

References 31 publications

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“…They adhered to the notion that confirmation by needle biopsy sets the stage for ra diation therapy, and their notably low five-year survival rates in the range of 20% assume significance in this regard. By contrast, Smith, L ampe and K ahn [65] condemned radiation therapy without adequate surgical decompression and reported the highest five-year survival yet, 62%, among eight patients treated with more recent irradiation techniques. T ice [67] summarized reports appearing prior to 1962 which, in the present context, have historical interest only.…”

Section: Results Of Radiation Therapymentioning

confidence: 99%

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Medulloblastoma. Current Views Regarding the Tumor and its Treatment

Wilson¹

1970

Oncology

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Present evidence supports the original view of the medulloblast as a bipo-tential cell with the capacity for differentiation along either spongioblastic or neuro-blastic lines. Medulloblastomas behave much like other tumors of presumed embryonal origin, and in this respect the period describing risk of recurrence after treatment follows Collins’ rule of age at the time of treatment plus nine months. Always regarded as highly radiosensitive, medulloblastomas now emerge as radio-curable with almost one-third of postoperative patients surviving ten years beyond radiation therapy. Clinical trials have shown the sensitivity of medulloblastomas to two oncolytic drugs, methotrexate and vincristine. The rationale behind intermittent intrathecal administration of methotrexate is presented in the light of present knowledge. In the future, chemotherapy will assume an increasingly important role in the treatment of medulloblastomas resisting cure by irradiation.

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Section: Results Of Radiation Therapymentioning

confidence: 99%

“…In current practice, primary operative removal of medulloblasto mas carries a mortality of about 20% [3,6,65]. Although operation alone has not produced a single documented cure, the surgeon's objective should be radical tumor removal.…”

Section: Results Of Surgical Removalmentioning

confidence: 99%

Medulloblastoma. Current Views Regarding the Tumor and its Treatment

Wilson¹

1970

Oncology

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“…The earliest studies signalled the hazards of radiation therapy to the immature brain in terms of impaired intelleetual development (Paterson and Farr, 1953;Smith et al, 1961). Later, more detaile d assessments confirmed the presenee of serious intelleetual defidts and also of emotional disturbanee (Hireh et al, 1979;Raimondi and Tomita, 197ge;Park et al, 1983;Silverman et al, 1984).…”

Section: Radiation Therapymentioning

confidence: 98%

Management of Brain Tumours in Childhood

Punt¹

1995

Malignant Brain Tumours

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“…Prior to the development of adjuvant radiotherapy, medulloblastoma was rarely survivable [10,11]. Outcomes have improved with modern treatment and now 5-and 10-year survival rates of 53-66% and 45-54%, respectively, can be expected [12,13].…”

Section: Introductionmentioning

confidence: 99%