The Prognosis of Noncutaneous, Nonlymphomatous Malignancy After Heart Transplantation: Data From the Spanish Post-Heart Transplant Tumour Registry

Abstract

Mortality among HT patients with post-HT NCNL solid organ cancers was highest for cancers of the liver or lung (79%-85% at 5 years), and lowest for prostate cancer (23%).

Incidence, Risk Factors, and Preventative Management of Skin Cancers in Organ Transplant Recipients: A Review of Single- and Multicenter Retrospective Studies from 2006 to 2010

“…Sex plays a strong role, with men having greater risk of developing NMSC than women. [22][23][24]27,32,33 Longer post-transplantation follow-up time is also correlated with NMSC development. [22][23][24]27,32,33 Longer post-transplantation follow-up time is also correlated with NMSC development.…”

“…Longer duration of immunosuppression correlates with greater number of SCCs. 24,32 The presence of premalignant infections such as human papillomavirus (HPV) and post-transplant viral warts 23 are risk factors for NMSC in the setting of chronic immunosuppression. 32,35 Two studies found that induction therapy with OKT3 and anti-thymocyte globulin therapy increased the incidence of NMSC.…”

“…34 Azathioprine and tacrolimus were associated with greater risk of developing skin cancer. 36 One factor for the 34 Men had AK and SCC more frequently than women Molina et al 32 Men had a higher risk of SCC but not BCC Navarro et al 27 Men had higher risk of developing NMSC Comeau et al 23 Men had higher risk of developing NMSC Crespo-Leiro et al 24 Incidence per 1,000 person-years was higher in men than women Age at transplantation Keller et al 34 Older patients had AK more frequently than younger patients Tessari et al 65 Higher risk for older OTR ( ! 24,32 The presence of premalignant infections such as human papillomavirus (HPV) and post-transplant viral warts 23 are risk factors for NMSC in the setting of chronic immunosuppression.…”

“…24,32 The presence of premalignant infections such as human papillomavirus (HPV) and post-transplant viral warts 23 are risk factors for NMSC in the setting of chronic immunosuppression. 50) Molina et al 32 Older age (>45) associated with higher risk of SCC and BCC Navarro et al 27 Older recipient age associated with higher risk of NMSC Comeau et al 23 Individuals aged >45 had higher risk of developing NMSC Arichi et al 128 Older age at transplantation was significant risk factor for development of malignancy Crespo-Leiro et al 24 Incidence per 1,000 person-years increased from 4.6 in younger patients (<45) to 26.5 in older patients ( ! 30) Abbaszadeh and Taheri 58 Incidence of KS was significantly associated with older age at transplantation Vajdic et al 75 Melanoma risk was positively associated with older age Wisgerhof et al 35 Older age at transplantation was risk factor for SCC and BCC Vegso et al 33 Risk of developing malignancy greater with age in RTR Moloney et al 22 Higher risk for older RTR ( !…”

“…36 One factor for the 34 Men had AK and SCC more frequently than women Molina et al 32 Men had a higher risk of SCC but not BCC Navarro et al 27 Men had higher risk of developing NMSC Comeau et al 23 Men had higher risk of developing NMSC Crespo-Leiro et al 24 Incidence per 1,000 person-years was higher in men than women Age at transplantation Keller et al 34 Older patients had AK more frequently than younger patients Tessari et al 65 Higher risk for older OTR ( ! 65À) Duration of immunosuppression Keller et al 34 Longer duration of immunosuppression correlated with greater number of AK and SCC Moloney et al 22 Higher risk of NMSC was associated with longer duration of immunosuppression Type of immunosuppressant Keller et al 34 Prednisone was found to be correlated with higher risk of developing AK Tessari et al 65 Combined immunosuppressive therapy with MMF, prednisolone, and cyclosporine A was associated with higher risk of KS, especially during first 2 years after transplantation Wisgerhof et al 35 Azathioprine was associated with higher risk of SCC in RTR than cyclosporine A and MMF; azathioprine was associated with higher risk of SCC in simultaneous pancreas and kidney transplant recipients than MMF Molina et al 32 Azathioprine was associated with higher risk of SCC; MMF and Tac were associated with lower risk of NMSC Navarro et al 27 Therapy with Tac was associated with higher risk of developing skin cancer Crespo-Leiro et al 24 Use of MMF and of tacrolimus (3 months after heart transplantation) was associated with lower incidence of skin cancer Induction therapy Crespo-Leiro et al 24 Induction therapy with muromonab-CD and antithymocyte globulin was risk factor for skin cancer Molina et al 32 Induction therapy increased risk of SCC and BCC Skin type Keller et al 34 Patients with fair skin had more AK and SCC than dark-skinned patients pathogenesis of post-transplantation viral warts is believed to be HPV, which infect the squamous epithelia of the skin and are increasingly active in the immunosuppressed host. 50) Molina et al 32 Older age (>45) associated with higher risk of SCC and BCC Navarro et al 27 Older recipient age associated with higher risk of NMSC Comeau et al 23 Individuals aged >45 had higher risk of developing NMSC Arichi et al 128 Older age at transplantation was significant risk factor for development of malignancy Crespo-Leiro et al …”