The prognosis of patients with gastric cancer possessing sex hormone receptors

Matsui, Michinori; Kojima, Osamu; Kawakami, Sadao; Uehara, Yasuo; Takahashi, Toshio

doi:10.1007/bf00308791

Cited by 87 publications

(68 citation statements)

References 17 publications

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“…Their analysis supported the hypothesis that longer exposure to the estrogen effects of either ovarian or exogenous origin may decrease the risk of gastric cancer. On the other hand, Matsui et al [17] reported that, in reviewing the immunohistology of 107 patients with curative resection of gastric cancer, the estrogen receptor-positive rate was slightly higher in younger female patients and in patients with poorly differentiated gastric cancer, and the 10-year cumulative survival rate after surgery was significantly lower in the estrogen receptor-positive cases. The relationship between sex hormones and cancer development needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach

et al. 2013

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Background Signet ring cell carcinoma (SRC) of the stomach is a histological type based on microscopic characteristics. Although the distinctive clinicopathological features of SRC have been reported, results are inconsistent and survival outcomes are uncertain. Methods We retrospectively studied 769 patients with gastric carcinoma who underwent gastrectomy in our institute from 1999 to 2009. Among them, 326 patients (42.4 %) had early gastric cancer (EGC) and 443 patients (57.6 %) had advanced gastric cancer (AGC). Sex, age, tumor location, macroscopic type, tumor size, microscopic invasion, and survival rate were compared between patients with SRC, differentiated-, and undifferentiated-type gastric carcinomas. Results Fifty-one patients (15.6 %) had SRC in EGC; there were significant differences in sex, age, location, macroscopic type, and size between SRC and the differentiated histological type. However, there was no difference between SRC and undifferentiated-type gastric carcinoma, except for the macroscopic type. Fifty-seven patients (12.9 %) had SRC in AGC. Sex, age, location, size, macroscopic type, perineural invasion, N stage, and hepatic metastasis were significantly different between SRC and the differentiated histological type. Undifferentiated-type gastric carcinoma differed in sex, macroscopic type, and hepatic metastasis. The overall survival rate differed between SRC and other cell types (P \ 0.001). Among all the study patients, age [hazard ratio (HR) 1.013, P = 0.041] and tumor, node, and metastasis (TNM) stage (HR 2.350, P \ 0.001) were important factors for predicting survival. Omitting patients with palliative resection or metastases, TNM stage was still an important factor for survival (HR 2.077, P \ 0.001). Conclusions Patients with SRC showed similar clinicopathological features with undifferentiated histology. The survival of patients with SRC reflected a better prognosis in patients with undifferentiated gastric carcinoma. However, when narrowing the patients to those with EGC only, survival in EGC patients exhibited no difference between histological types. Among AGC patients, SRC patients had a worse prognosis than other cell types.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach

et al. 2013

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“…However, studies have shown that some primary gastric cancers can have ER/PR positivity. 2 Further, if the primary breast lesion is ER/PR negative, it cannot be used as a marker. Other immunohistochemistry markers that have been used include HER2/neu; gross cystic disease fluid protein (GCDFP-15); CK7, CK8, and CK20; mucin glycoprotein antigens (MUC2), MUC5AC, and MUK6; and caudal-type homeobox transcription factor CDX2.…”

Section: Discussionmentioning

confidence: 99%

“…When the primary breast tumor is positive for estrogen and progesterone receptors (ER/PRs) and the stomach tumor is ER/PR negative, the diagnosis is established easily. 2 However, studies have shown that some primary gastric cancers can have ER/PR positivity. Further, if the primary breast lesion is ER/PR negative, the same cannot be used as a marker.…”

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confidence: 99%

Metachronous Multiple Primary Malignant Neoplasms of the Stomach and the Breast: Report of Two Cases With Review of Literature

Karthikeyan

Sistla

Srinivasan

et al. 2014

International Surgery

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Multiple primary malignant neoplasm is the occurrence of a second primary malignancy in the same patient within 6 months of the detection of first primary (synchronous), or 6 months or more after primary detection (metachronous). Multiple primary malignant neoplasms are not very frequently encountered in clinical practice. The relative risk for a second primary malignancy increases by 1.111-fold every month from the detection of the first primary malignancy in any individual. We present 2 patients treated for carcinoma of the breast who developed a metachronous primary malignancy in the stomach to highlight the rare occurrence of multiple primary malignant neoplasms. These tumors were histologically dissimilar, with distinct immunohistochemical parameters. The importance lies in carefully identifying the second primary malignancies, not dismissing them as metastases, and treating them accordingly.

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“…Based on the evidence that ERα is expressed in poorly differentiated adenocarcinomas more frequently than in well differentiated gastric cancer (39)(40)(41)(42)(43), several clinical trials using a partial estrogen antagonist, tamoxifen, have been conducted for the management of ERα-positive gastric cancer patients. However, the results have not been consistent, and the utility of ERα for the treatment of gastric cancer is still inconclusive (21,39,44,45).…”

Section: Estrogen Protects Against Gastric Cancer Through Ersmentioning

confidence: 99%

Overexpression of ERα inhibits proliferation and invasion of MKN28 gastric cancer cells by suppressing β-catenin

Zhou

Teng

et al. 2013

Oncology Reports

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Abstract.The relationship between estrogen receptor (ER)α and patient prognosis has been identified in gastric cancer; however, the definite role of ERα in gastric cancer remains to be fully elucidated. The aim of the present in vitro study was to investigate the impact of ERα on cell proliferation, migration and invasion in gastric cancer cell lines. We investigated the biological effect of ERα overexpression on gastric carcinoma cells. An MKN28 gastric cancer cell line stably overexpressing ERα was established. The effect of ERα overexpression on cell growth was assessed by evaluating cell survival, colony formation, cell cycle progression and apoptosis. Cell migration and invasion were detected by Transwell migration/invasion assays. The protein levels of several potentially involved genes were determined by western blotting to elucidate the underlying molecular mechanisms. The Student's t-test was used to determine the statistical differences between various experimental and control groups, and one-way ANOVA test was used to determine the difference between three or more groups. The results showed that ERα overexpression significantly inhibited cell growth and proliferation, blocked cell entry into the G1/G0 phase and promoted cell apoptosis. In addition, ERα reduced the motility and invasion of gastric cancer cells. These phenotypes may partly be explained by a decrease in β-catenin expression caused by ERα overexpression. ERα overexpression effectively inhibited cell growth and cancer progression by suppressing β-catenin in gastric cancer, identifying ERα as a promising target with therapeutic potential for development of new approaches to treat gastric cancer.

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The prognosis of patients with gastric cancer possessing sex hormone receptors

Cited by 87 publications

References 17 publications

Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach

Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach

Metachronous Multiple Primary Malignant Neoplasms of the Stomach and the Breast: Report of Two Cases With Review of Literature

Overexpression of ERα inhibits proliferation and invasion of MKN28 gastric cancer cells by suppressing β-catenin

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