The prognosis of primary generalized epilepsy in patients with parental consanguinity – a 1-year retrospective study

Babtain, Fawzi; Assiri, Hussam; Bajunaid, A; Muthusamy,; Bhatia, Harsha

doi:10.7707/hmj.558

Cited by 1 publication

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“…Among the generalized seizures, 12(57.1%) generalized tonic clonic, 5(23.8%) tonic, 3(14.3%) myoclonic and 1(4.8%) clonic. Osman et al (2017) reported that among the epileptic children, 35 (58.3%) were with generalized tonic clonic seizures, 11(18.3%) had partial, 10(16.7%) had partial secondary generalization, 4(6.7%) had absence seizures which is almost comparable to our study [20]. In the current study, it was observed that almost three fourth (58.1%) of children had behavioral problems followed by 18(58.1%) children had developmental delay, 9(29.0%) had CP with developmental delay.…”

Section: Resultssupporting

confidence: 89%

“…Table 5 These findings are nearly similar to the current study [19]. "In another study, observed that among 60 epileptic patients, 38 males (63.3%) and 22 females (36.7%) diagnosed as having epilepsy on the basis of both clinical examination and investigation receiving antiepileptic drugs (AEDS) for at least one year" [20]. "The male-to-female ratio for children with epilepsy was 1.3:1.…”

Section: Resultssupporting

confidence: 82%

“…Though the difference was statistically not significant (p > 0.05) between types of therapy with BMD Z score. "Epileptic patients had lower BMD, Z-score, and AM compared with controls (P value < .001)" [20]. "Epileptic patients with LBMD had significant decrease in Z score, BMD and AM (P < .001) compared with epileptic patients with normal bone state.…”

Section: Resultsmentioning

confidence: 93%

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Bone Mineral Density in Epileptic Children Getting Long Term Anti-epileptic Drugs

Kabir,

Bodruddoza,

After

2023

AJPR

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Background: Epilepsy is a common chronic neurological disorder with more than half of cases beginning in childhood. Most patients require long-term, and sometimes life-long, therapy with antiepileptic drugs (AEDs). AEDs are associated with significant side effects including radiological evidence of rickets, decreased bone mineral density (BMD), altered bone turnover, and increased risk of fracture. Aim of the Study: To assess the bone mineral density in epileptic children getting long term anti-epileptic drugs. Materials and Methods: This study was conducted in the Saleh Child Development and Disability Management Center (SCDDMC), of the Institute of Child and Mother Health (ICMH) Matuail, Dhaka. A total of 31 childrens age ranged 5-15 years diagnosed as epilepsy on the basis of both clinical examination and investigation (EEG) receiving antiepileptic drugs (AEDS) for at least two years were recruited in this study. Results: Almost two third (61.3%) children age group were in 5 to 10 years and 12(38.7%) in 10 to 15 years. Around three fourth (74.2%) children were male and 8(25.8%) were female. More than two third (67.7%) children had adequate sun exposure and more than three fourth (77.4%) children got adequate calcium and vit.D rich food. Majority (83.9%) of the patients got phenobarbitone (PB) followed by 17(54.8%) got combination, 13(41.9%) got valproic acid (VPA), 11(35.5%) got Nitrazipum (NTZ). More than one third (38.7%) children got mono therapy, 19(61.3%) got polytherapy. Majority of the children (96.8%) had serum calcium normal. The mean serum calcium was 9.22±0.78 mg/dl. The mean BMD of spine was 0.66±0.14. The mean BMD of neck left femur was 0.66±0.15. The mean BMD of neck right femur 0.66±0.15. More than two third (67.7%) children had low (<-1SD) BMD Z score. Almost two third (60.0%) children had mono therapy showed BMD Z score normal (>-1SD) and 6(28.6%) had BMD Z score low (<-1SD). Almost three fourth (71.4%) children got poly therapy showed low BMD and 4(20.0%) got poly therapy showed normal BMD Z score. No significant association was found between BMD score and type and duration of therapy. Conclusion: AEDs decreased bone mineral density due to long term use as mono-therapy or polytherapy. The assessment of BMD among children with epilepsy receiving long term AEDs is essential.

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Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 93%

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