The Prognosis of Transient Global Amnesia

Hinge, Hans-H.; Jensen, Troels Staehelin; Kjær, Mogens; Marquardsen, J; Olivarius, Bent de Fine

doi:10.1001/archneur.1986.00520070031013

Cited by 58 publications

(33 citation statements)

References 22 publications

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“…Seventy-one percent of our patients had TRF: our data are compara ble with those of Shuping et al [17] (63%), Jensen and Olivarius [18] (64%) and Cattaino et al [20] (77%), while they are higher than those of Matias-Guiu et al [16] (41%) and Hinge et al [19] (37%) and lower than those of Mathew and Meyer [10] (92%).…”

Section: Discussionsupporting

confidence: 56%

“…A good prognosis is confirmed by stud ies of Shuping ct al. [ 17], Jensen and Olivarius [ 18] and Hinge et al [19], although Jensen and Olivarius [18] state that TGA prognosis worsens when thrombotic risk factors (TRF) coexist. The aim of this research is to study the pathogenesis and prognosis of TGA and to contribute further data to the solution of this problem.…”

Section: Introductionmentioning

confidence: 99%

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Transient Global Amnesia: Pathogenesis and Prognosis

Colombo

Scarpa

1988

Eur Neurol

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Fifty-five patients admitted to hospital for ‘pure’ transient global amnesia (TGA) were studied and followed up for a period ranging from 12 to 67 months. The major pathogenetic theories of TGA (epileptic, thrombotic and migrainous) were investigated through the study of clinical histories and risk factors and the recurrences of neurological disturbances during follow-up. Seventy-one percent of the sample had one or more thrombotic risk factors (TRF), 2 patients had both TRF and a history of migraine, and none ever experienced a seizure. A computerized tomography (CT) scan was performed in 40 out of 55 patients to detect focal lesions: 3 patients (7.5%) had a lacuna in the deep structures of the brain. Over the follow-up period, 1 patient died from hepatic cirrhosis, 1 patient died from cerebral haemorrhage, 2 patients experienced transient ischaemic attacks and 3 patients had a total of 4 TGA recurrences. Our conclusion is that TGA represents a benign form of transient ischaemic cerebral disease.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Transient Global Amnesia: Pathogenesis and Prognosis

Colombo

Scarpa

1988

Eur Neurol

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“…Most patients with TGA have only a single attack. The recurrence rate is 2.5^5% per year for at least ¢ve years after the initial episode (Hinge et al 1986;Miller et al 1987;Nausieda & Sherman 1979;Shuping et al 1980;Zorzon et al 1995).…”

Section: T R a N S I E N T G Lo Ba L A M N E S I Amentioning

confidence: 99%

Transient global amnesia and functional retrograde amnesia: contrasting examples of episodic memory loss

Kritchevsky

Zouzounis

Squire

1997

Phil. Trans. R. Soc. Lond. B

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We studied 11 patients with transient global amnesia (TGA) and ten patients with functional retrograde amnesia (FRA). Patients with TGA had a uniform clinical picture: a severe, relatively isolated amnesic syndrome that started suddenly, persisted for 4^12 h, and then gradually improved to essentially normal over the next 12^24 h. During the episode, the patients had severe anterograde amnesia for verbal and non-verbal material and retrograde amnesia that typically covered at least two decades. Thirty hours to 42 days after the episode, the patients had recovered completely and performed normally on tests of anterograde and retrograde amnesia. By contrast, patients with FRA had a sudden onset of memory problems that were characterized by severe retrograde amnesia without associated anterograde amnesia and with a clinical presentation that otherwise varied considerably. The episodes persisted from several weeks to more than two years, and some of the patients had not recovered at the time of our last contact with them. The uniform clinical picture of TGA and the variable clinical picture of FRA presumably re£ect their respective neurologic (`organic') and psychogenic (`non-organic') aetiologies.

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“…Accumulated case series have provided data on the precipitants, clinical picture and neuropsychological profile of TGA [1][2][3], but its pathophysiology remains obscure. The abrupt onset and brief duration of TGA point to a disturbance of neuronal and/or vascular origin located in the key structures of memory, i.e.…”

Section: Introductionmentioning

confidence: 99%

Transient Global Amnesia and Migraine

Schmidtke

Ehmsen²

1998

Eur Neurol

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This study examined the putative association of transient global amnesia (TGA) and migraine. 57 TGA patients were compared to a double-size control group of normal subjects. TGA patients who also had migraine were additionally compared to those without migraine and to a second control group of outpatients with migraine only. The prevalence of migraine, and also of episodic tension-type headache, was markedly increased among TGA patients. Precipitants and accompanying vegetative symptoms of TGA and migraine overlapped. However, there was no evidence of an interaction between TGA and migraine, in that the expression of key TGA features was not affected by comorbidity with migraine, and vice versa. The present findings argue against the hypothesis that TGA represents a type of migraine aura or migraine equivalent. They conform to the hypothesis that the two conditions are essentially independent and result from an inherited brain state that disposes to different types of paroxysmal dysregulation, presumably at the level of the brain stem.

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The Prognosis of Transient Global Amnesia

Cited by 58 publications

References 22 publications

Transient Global Amnesia: Pathogenesis and Prognosis

Transient Global Amnesia: Pathogenesis and Prognosis

Transient global amnesia and functional retrograde amnesia: contrasting examples of episodic memory loss

Transient Global Amnesia and Migraine

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