The Prognostic Ability of Log Odds of Positive Lymph Nodes in Oral Cavity Squamous Cell Carcinoma

Abstract

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Incorporation of log odds of positive lymph nodes into the AJCC TNM classification improves prediction of survival in oral cancer

“…Third, none of the patients in our study had N3 disease. In our previous study, only 0.3% of patients had N3 disease . Future researchers should consider recruitment of patients with stage N3 cancer.…”

“…Different to LNR, LODDS is able to discriminate among patients with the same ratio of node metastasis but different survival rates especially for those with insufficient LN examination achieved. Our previous study showed LODDS had better discrimination than pN classification for those with <5 neck metastases . LODDS also had better discrimination than LNR classification in OSCC patients with LNR <0.2 or >0.6.…”

“…However, the pathological factors such as tumour thickness, perineural invasion (PNI) and lymphovascular permeation which played as an important prognostic role were not included in our previous analysis and the number in each subgroup was relatively small in the preliminary 3-year follow-up study. 12 Furthermore, management of OSCC is based on the pathological TNM staging of patient specimens currently. Given this background, we reserve the routinely used pN classification by addition of the LODDS category to establish a 'new N' classification.…”

“…The literature related to the LODDS in head and neck cancer was scant. Our previous research first reported the discriminability of LODDS in oral cancer . Yildiz et al .…”

“…also demonstrated that LODDS behaviour better prediction for overall survival in oral cancer in Western countries, compared with LNR or AJCC pN category. However, the pathological factors such as tumour thickness, perineural invasion (PNI) and lymphovascular permeation which played as an important prognostic role were not included in our previous analysis and the number in each subgroup was relatively small in the preliminary 3‐year follow‐up study . Furthermore, management of OSCC is based on the pathological TNM staging of patient specimens currently.…”