The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression

Fang, Jian; Yangyang, Ren; Xu, Wei; Jiadan, Xu; Na, Li; Yang, Peng; Bian, Maohong; Niu, Guoping; Pan, Zhaoji

doi:10.3389/fonc.2020.549982

Cited by 9 publications

(6 citation statements)

References 79 publications

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“…CDR1as is located on the X chromosome (chrX: 139865339–139866824) and is 1,485 bp in size. CDR1as has been discovered in multiple tumors and participates in various biological processes, such as proliferation, invasion, and migration ( Jian et al, 2020 ). In glioma, CDR1as can disrupt the complex of p53 and MDM2 to inhibit tumorigenesis ( Lou et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Circular RNA CDR1as Alleviates Cisplatin-Based Chemoresistance by Suppressing MiR-1299 in Ovarian Cancer

Zhao

Wang

et al. 2022

Front. Genet.

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Cisplatin (CDDP) chemoresistance seriously affects the prognosis and survival of patients with ovarian cancer (OC). Previous research has shown that circular RNA CDR1as is biologically associated with a large number of cancers. However, the molecular mechanism underlying the role of CDR1as in CDDP chemoresistance in OC remains unclear. Here, we investigated the mechanism of CDR1as in CDDP-resistant OC. First, we employed bioinformatics analysis and quantitative real-time PCR (qRT-PCR) to determine the expression of CDR1as and related RNAs in CDDP-sensitive and -resistant OC tissues and cells. Then, functional experiments were used to determine cell proliferation, invasion, migration, and apoptosis in CDDP chemoresistance and parent OC cells in vitro. The effect of CDR1as in CDDP chemoresistance OC progression was tested in nude mice in vivo. Moreover, dual-luciferase assays and RNA immunoprecipitation (RIP) were performed to confirm the interactions of CDR1as and related RNAs. Finally, we used Western blotting to determine protein expression levels. Our findings interpret the underlying mechanisms of the CDR1as/miR-1299/PPP1R12B axis and shed light on the clinical applications for CDDP-chemoresistant OC.

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Section: Introductionmentioning

confidence: 99%

Circular RNA CDR1as Alleviates Cisplatin-Based Chemoresistance by Suppressing MiR-1299 in Ovarian Cancer

Zhao

Wang

et al. 2022

Front. Genet.

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“…Upregulation of circ_0001946 has been found in numerous types of cancer including glioma and lung cancer. Thus, circ_0001946 is a novel oncogenic factor in tumor progression [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Our data, consistent with previous findings, revealed the upregulation of circ_0001946 in AML cells.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, circPICALM could sponge miR-1265 and suppress bladder cancer metastasis, consequently affecting the phosphorylation of FAK [ 19 ]. Among these circRNAs, circ_0001946 is particularly well studied and it functions as an oncogenic regulator; the dysregulation of circ_0001946 was detected in numerous types of cancer, associated with tumor progression through its effect of cancer cell growth [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. However, the full roles and downstream signaling of most circRNAs including circ_0001946 in AML are not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Circ_0001946 Promotes the Development of Acute Myeloid Leukemia by Upregulating PDL1

Li¹,

Zhu²,

Qiao³

et al. 2023

Tjh

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Objective: Circ_0001946 has been identified as an oncogenic factor, and the aim of this study was to explore the detailed roles and putative targets of circ_0001946 in acute myeloid leukemia (AML). Materials and Methods: Levels of circ_0001946 were examined in AML tissues and cells. Furthermore, the regulatory functions of circ_0001946 in AML were explored. The expression of circ_0001946 was evaluated in AML samples and a matched para-carcinoma control, as well as in AML cell lines and a human bone marrow stromal cell line using reverse transcription-quantitative polymerase chain reaction. Cell proliferation was examined using a CCK-8 kit, and migration/invasion was measured by transwell assay. Furthermore, interactions between associated molecules were assessed using RNA pulldown, and the mRNA stability of the relevant gene was examined by mRNA stability assay. Results: Our data indicated that circ_0001946 was upregulated in AML specimens/cells. Additionally, overexpression of circ_0001946 promoted the proliferation, migration, and invasion of AML cells and, vice versa, these biological processes were suppressed by knockdown of circ_0001946. Furthermore, PDL1 is a potential downstream molecule of circ_0001946 in AML and its stability was improved by circ_0001946. The expression of PDL1 was increased in AML specimens and positively correlated with circ_0001946 expression. Moreover, biological behavioral alterations in AML cells induced by oe-circ_0001946 were abrogated by sh-PDL1 and the effects of sh-circ_0001946 were enhanced by treatment with sh-PDL1. Conclusion: Taken together, these data suggest that levels of circ_0001946 are elevated in AML and that circ_0001946 could promote the growth of AML cells. Furthermore, PDL1 is a novel downstream molecule of circ_0001946 in AML. Circ_0001946/PDL1 signaling may play crucial roles in tumor progression in AML and could be a novel candidate for targeted treatments for AML patients.

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“…Circular RNAs (circRNAs) are a class of single-stranded RNAs with multiple biological functions (Tang et al, 2021). Unlike conventional linear RNAs, circRNAs are characterized by a covalently bonded loop structure that lacks 5′caps and 3′ poly(A) tails (Jian et al, 2020). Since the first discovery of circRNAs in RNA viruses in 1976, circRNAs were largely regarded as a by-product of misspliced transcripts, so they were not thoroughly studied (Kolakofsky, 1976).…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0009128 mediates progression of oral squamous cell carcinoma by influencing MMP9

2021

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Oral cancer is a malignancy, characterized by high morbidity and mortality (Inchingolo et al., 2020). Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral cancers, with approximately 25,000 new cases of OSCC diagnosed each year in Asian countries, and morbidity of OSCC has a tendency to increase (Abati et al., 2020).Oral carcinogenesis is a multistep process involving multiple genetic alterations (Avci et al., 2017). Even with improvements in surgical treatment, prognosis for OSCC patients remains poor, which may be largely attributed to metastatic relapse. Hence, it is urgent to define the mechanism of carcinogenesis in OSCC. In recent years, circRNAs have emerged in the field of noncoding RNAs and have become a new research hotspot(Goodall & Wickramasinghe, 2021). CircRNAs are a subgroup of single-stranded RNA molecules with a closed-loop structure lacking 5′ and 3′ ribonucleotide ends, making them remarkably stable in eukaryotes(Chen et al., 2020). With recent innovations in sequencing technology and

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The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression

Cited by 9 publications

References 79 publications

Circular RNA CDR1as Alleviates Cisplatin-Based Chemoresistance by Suppressing MiR-1299 in Ovarian Cancer

Circular RNA CDR1as Alleviates Cisplatin-Based Chemoresistance by Suppressing MiR-1299 in Ovarian Cancer

Circ_0001946 Promotes the Development of Acute Myeloid Leukemia by Upregulating PDL1

Hsa_circ_0009128 mediates progression of oral squamous cell carcinoma by influencing MMP9

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