The prognostic, immunological and single-cell features of m6A molecules in cervical cancer

Xiaoqiu  Zhu,; Xiaolu  Song,; Qi  Chen,; Ye  Peng,; Fangfang Shi,

doi:10.14715/cmb/2023.69.9.13

Cell Mol Biol (Noisy-le-grand)

2023

DOI: 10.14715/cmb/2023.69.9.13

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The prognostic, immunological and single-cell features of m6A molecules in cervical cancer

Xiaoqiu Zhu,

Xiaolu Song,

Qi Chen

et al.

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2024

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Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications

Modi,

Zahid,

Southerland

et al. 2024

Expert Rev. Mol. Med.

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Cervical cancer (CC), one of the most prevalent and detrimental gynaecologic cancers, evolves through genetic and epigenetic alterations resulting in the promotion of oncogenic activity and dysfunction of tumour-suppressing mechanisms. Despite medical advancement, the prognosis for advanced-stage patients remains extremely low due to high recurrence rates and resistance to existing treatments. Thereby, the search for potential prognostic biomarkers is heightened to unravel new modalities of CC pathogenesis and to develop novel anti-cancer therapies. Epitranscriptomic modifications, reversible epigenetic RNA modifications, regulate various biological processes by deciding RNA fate to mediating RNA interactions. This narrative review provides insight into the cellular and molecular roles of endogenous RNA-editing proteins and their associated epitranscriptomic modifications, especially N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine (m1A), in governing the development, progression and metastasis of CC. We discussed the in-depth epitranscriptomic mechanisms underlying the regulation of over 50 RNAs responsible for tumorigenesis, proliferation, migration, invasion, survival, autophagy, stemness, epithelial-mesenchymal transition, metabolism (glucose, lipid, glutamate and glutamine), resistance (drug and radiation), angiogenesis and recurrence of CC. Additionally, we provided a concise overview of the therapeutic potential of targeting the altered expression of endogenous RNA-editing proteins and aberrant deposition of RNA modifications on both coding and non-coding RNAs in CC.

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Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications

Modi,

Zahid,

Southerland

et al. 2024

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

show abstract

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The prognostic, immunological and single-cell features of m6A molecules in cervical cancer

Cited by 1 publication

References 60 publications

Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications

Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications

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The prognostic, immunological and single-cell features of m6A molecules in cervical cancer

Cited by 1 publication

References 60 publications

Epitranscriptomics and cervical cancer: the emerging role of m6A, m5C and m1A RNA modifications

Epitranscriptomics and cervical cancer: the emerging role of m6A, m5C and m1A RNA modifications

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Product

Resources

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Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications

Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications