The prognostic impact of hyperglycemia on clinical outcomes of acute heart failure: Insights from the heart function assessment registry trial in Saudi Arabia

Aljohar, Alwaleed; AlHabib, Khalid F.; Kashour, Tarek; Hersi, Ahmad; Habeeb, Waleed Al; Ullah, Anhar; Elasfar, Abdelfatah; Almasood, Ali; Ghabashi, Abdullah; Mimish, Layth; Alghamdi, Saleh; Abuosa, Ahmed; Malik, Asif; Hussein, Gamal; Al-Murayeh, Mushabab; AlFaleh, Hussam

doi:10.1016/j.jsha.2018.06.001

Cited by 7 publications

(8 citation statements)

References 47 publications

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“…Kattel et al showed that 1.8 year-mortality was higher in ADHF patients with higher admission glucose level [7]. However, Aljohar et al reported that HGL on admission is independently associated with hospital and short-term mortality in AHF patients [20]. In the contrary, Kosiborod et al reported that they found no significant association between admission glucose levels and mortality in a large cohort of 50,532 elderly patients hospitalized with heart failure [9].…”

Section: Admission Hgl or Dm And 1-year Deathmentioning

confidence: 99%

Admission Hyperglycemia as a Predictor of Mortality in Acute Heart Failure: Comparison between the Diabetics and Non-Diabetics

Cho

Kim

Lee

et al. 2020

JCM

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Background: To investigate the impact of admission hyperglycemia (HGL) on in-hospital death (IHD) and 1-year mortality in acute heart failure (AHF) patients with or without diabetes mellitus (DM). Methods: Among 5625 AHF patients enrolled in a nationwide registry, 5541 patients were divided into four groups based on the presence of admission HGL and diabetes mellitus (DM). Admission HGL was defined as admission glucose level > 200 mg/dL. IHD and 1-year mortality were compared. Results: IHD developed in 269 patients (4.9%), and 1-year death developed in 1220 patients (22.2%). DM was a significant predictor of 1-year death (24.8% in DM vs. 20.5% in non-DM, p < 0.001), but not for IHD. Interestingly, admission HGL was a significant predictor of both IHD (7.6% vs. 4.2%, p < 0.001) and 1-year death (26.2% vs. 21.3%, p = 0.001). Admission HGL was a significant predictor of IHD in both DM and non-DM group, whereas admission HGL was a significant predictor of 1-year death only in non-DM (27.8% vs. 19.9%, p = 0.003), but not in DM group. In multivariate analysis, admission HGL was an independent predictor of 1-year mortality in non-DM patients (HR 1.32, 95% CI 1.03–1.69, p = 0.030). Conclusion: Admission HGL was a significant predictor of IHD and 1-year death in patients with AHF, whereas DM was only a predictor of 1-year death. Admission HGL was an independent predictor of 1-year mortality in non-DM patients with AHF, but not in DM patients. Careful monitoring and intensive medical therapy should be considered in AHF patients with admission HGL, regardless of DM.

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Section: Admission Hgl or Dm And 1-year Deathmentioning

confidence: 99%

Admission Hyperglycemia as a Predictor of Mortality in Acute Heart Failure: Comparison between the Diabetics and Non-Diabetics

Cho

Kim

Lee

et al. 2020

JCM

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“…Hyperglycemia in hospitalized patients may be caused not only by the poor glycemic control in diabetes but also by a transient stress response to current disease states [26]. Previous studies have confirmed hyperglycemia at admission is independently associated with hospitalization and short-term mortality in AHF patients and is an independent predictor of 1-year mortality in non-diabetic (DM) patients with AHF [27,28]. Furthermore, higher preoperative PLOS ONE blood glucose level was significantly related to a prolonged LOS for patients undergoing appendectomy or laparoscopic cholecystectomy [29].…”

Section: Plos Onementioning

confidence: 99%

The association between serum albumin and long length of stay of patients with acute heart failure: A retrospective study based on the MIMIC-IV database

et al. 2023

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Background The purpose of this article is to assess the relationship between serum albumin level and long length of stay (LOS) of inpatients with acute heart failure (AHF) in the intensive care unit (ICU). Methods We retrospectively analyzed data of 2280 patients with AHF from the medical information mart for intensive care IV (the MIMIC-IV) database. Multivariate logistic regression was performed to evaluate the association between serum albumin and long LOS, and the development of the predictive model was based on independent predictors of long LOS. Results According to the statistical results, A negative linear relationship was presented between albumin and long LOS of AHF patients in the ICU (P for trend <0.001), and serum albumin could predict long LOS (AUC 0.649, 95%CI 0.616–0.683, P <0.001). Based on independent predictors, including respiratory failure (OR 1.672, 95%CI 1.289–2.169, P<0.001), WBC (OR 1.046, 95%CI 1.031–1.061, P<0.001), creatinine (OR 1.221, 95%CI 1.098–1.257, P<0.001), glucose (OR 1.010, 95%CI 1.007–1.012, P<0.001), lactic acid (OR 1.269, 95%CI 1.167–1.381, P<0.001), and albumin (OR 0.559, 95%CI 0.450–0.695, P<0.001), identified by multivariable logistic regression analysis, we developed the nomogram to predict the probability of long LOS of AHF patients in the ICU. The nomogram accurately predicted the probability of long LOS (AUC 0.740, 95%CI 0.712–0.768, P<0.001). The calibration suggested the predictive probability was highly consistent with the actual probability of long LOS. Decision curve analysis (DCA) also suggested that the nomogram was applicable in the clinic. Conclusion Serum albumin level was negatively associated with LOS among AHF patients. The predictive model based on serum albumin has predictive value for evaluating the length of stay in AHF patients.

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“…Studies are still controversial regarding the association between admission blood sugar levels and the prognosis of acute heart failure patients. Some studies suggest that elevated admission blood sugar levels and stress hyperglycemia are associated with a significantly worse prognosis over a short period in acute heart failure patients, regardless of diabetes diagnosis and other clinical variables [6][7][8]. The poor prognosis is thought to be associated with the role of elevated blood sugar levels in worsening ventricular function through several pathways, including oxidative stress that damages cardiomyocytes [9].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, stress hyperglycemia has been widely studied in patients with acute coronary syndrome and has become an integral part of the management of sudden cardiac arrest, according to the recommendations of the American Heart Association in 2013 [12]. The American Diabetes Association also recommends strict control of admission blood sugar levels regardless of the disease, which has little practical application in the management of heart failure [8]. Hence, it is crucial to gain more comprehension on the relationship between admission blood sugar levels and the length of stay of patients with acute heart failure, especially in areas with high prevalence such as Aceh Province.…”

Section: Introductionmentioning

confidence: 99%

Association between admission blood sugar levels and length of stay among patients with acute heart failure: A cross-sectional study in Aceh, Indonesia

Gusti,

Heriansyah,

Saputra

2023

Narra X

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Heart failure persists to be a major health problem worldwide. Numerous factors associated with this condition have been studied to determine its prognosis. History of diabetes mellitus is one of the factors extensively studied, nonetheless, the correlation between acutely elevated admission blood glucose in critically ill patients or stress hyperglycemia towards the prognosis of heart failure remains inconclusive among previously reported studies. Therefore, the aim of this study was to investigate the correlation between admission blood glucose and the length of stay of acute heart failure patients. A cross-sectional study was conducted in Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia from July to August 2020. Patients’ data were retrieved from medical records documenting admission blood glucose and length of stay. Total sampling was employed, where eighty-five patients diagnosed as acute heart failure were included. The results showed that patients (n=85) had the general characteristics of being normoglycemic on admission (69.4%) and having 5–10 days length of stay (44.7%) with Killip 2 as the presiding Killip Class (50.6%). According to Gamma’s Correlation Coefficient, the p-value of this study is 0.012 (p< 0.05) with a correlation value of 0.454. Therefore, our study revealed the presence of a significant moderate-correlation between admission blood glucose and the length of stay among patients with acute heart failure.

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The prognostic impact of hyperglycemia on clinical outcomes of acute heart failure: Insights from the heart function assessment registry trial in Saudi Arabia

Abstract: HG on admission is independently associated with hospital and short-term mortality in AHF patients. Future research should focus on examining the impact of tight glycemic control on outcomes of AHF patients.

Cited by 7 publications

References 47 publications

Admission Hyperglycemia as a Predictor of Mortality in Acute Heart Failure: Comparison between the Diabetics and Non-Diabetics

Admission Hyperglycemia as a Predictor of Mortality in Acute Heart Failure: Comparison between the Diabetics and Non-Diabetics

The association between serum albumin and long length of stay of patients with acute heart failure: A retrospective study based on the MIMIC-IV database

Association between admission blood sugar levels and length of stay among patients with acute heart failure: A cross-sectional study in Aceh, Indonesia

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