The Prognostic Importance of the Systemic Inflammatory Index in Pathologies of the Larynx

Abstract

This study aimed to determine the prognostic importance of the preoperative systemic immune-inflammatory index (SII) in laryngeal lesions and to investigate its predictive importance compared to the neutrophil-lymphocyte ratio (NLR) and plateletlymphocyte ratio (PLR). Material and Methods: Retrospective comparisons were made between the preoperative blood parameters (NLR, PLR, and SII) and clinicopathological features of 133 patients who underwent surgery for a localized laryngeal lesions between March 01, 2010 and June 31, 2021. Receiver-operating characteristic analysis was used to calculate the cut-off value of the SII. Results: Of the 133 patients with laryngeal lesions, 81 (60.9%) had benign lesions, 20 (15%) had premalignant lesions, and 32 (24.1%) had malignant pathology results. The mean SII value was determined to gradually increase in the order of benign, premalignant, and malignant pathology (444.36; 525.69; 738.07, respectively). A statistically significant difference was found between the SII values of the groups classified as benign, premalignant, and malignant according to laryngeal pathologies (p<0.001). A statistically significant moderate-level correlation of approximately 35% was determined between the benign, premalignant, and malignant pathology results and SII, between the pathology results and NLR at 36%, and with PLR at 29%. Conclusion: A significant relationship was observed between the tendency of the disease and malignancy in laryngeal pathologies and the SII. This significant relationship was also determined by NLR and PLR. In this context, the SII was evaluated as an inexpensive, routine screening test that can be used to evaluate the prognosis of patients with laryngeal pathology.