The prognostic importance of thiol/disulfide homeostasis in patients with acute pulmonary thromboembolism

Changes in thiol/disulfide homeostasis in juvenile idiopathic arthritis

“…reported that in patients with acute appendicitis dynamic thiol/disulfide homeostasis shifted towards disulfide formation due to thiol oxidation. The importance of thiol/disulfide homeostasis in many diseases, including chronic renal disease, severe coronary disease, migraine, obstructive sleep apnea, and pulmonary thromboembolism, has been reported . In the present study, although the thiol/disulfide ratio was slightly higher in the JIA patients than in the controls, the difference was not significant.…”

“…The importance of thiol/disulfide homeostasis in many diseases, including chronic renal disease, severe coronary disease, migraine, obstructive sleep apnea, and pulmonary thromboembolism, has been reported. 5,6,[11][12][13][14] In the present study, although the thiol/disulfide ratio was slightly higher in the JIA patients than in the controls, the difference was not significant. The present small sample size may be why the present findings differ from those reported earlier by Altıparmak et al 6 In clinical practice CRP and ESR are used to predict the severity of inflammation in inflammatory disease.…”

“…An increase in production of pro‐inflammatory cytokines is associated with an increase in mediators of oxidative stress, which can damage DNA, lipids, and proteins . Thiols account for the major portion of the total antioxidants in the body and play an important role in programmed cell death, detoxification, antioxidant protection, and regulation of cellular enzymatic activity . The thiol pool in plasma is primarily composed of protein thiols, including albumin and the low‐molecular‐mass thiols glutathione, homocysteine, cysteine, and γ‐glutamine.…”

“…3 Thiols account for the major portion of the total antioxidants in the body and play an important role in programmed cell death, detoxification, antioxidant protection, and regulation of cellular enzymatic activity. 4,5 The thiol pool in plasma is primarily composed of protein thiols, including albumin and the low-molecular-mass thiols glutathione, homocysteine, cysteine, and c-glutamine. Under oxidative stress conditions thiol level decreases in order to neutralize reactive oxygen species (ROS).…”

Novel oxidative stress biomarker in sepsis: dynamic thiol-disulfide homeostasis

“…Various studies reported the importance of an abnormal TDH in acute pathological conditions. Topuz et al have demonstrated that TDH altered during acute pulmonary embolism and may use as a prognostic marker for hospital mortality 23 . Bektaş et al observed that thiol levels were lower in the acute ischemic stroke patients when compared to healthy controls 24 .…”