The prognostic role of micronutrient status and supplements in COVID-19 outcomes: A systematic review

Pechlivanidou, Evmorfia; Vlachakis, Dimitriοs; Tsarouhas, Konstantinos; Panidis, Dimitrios; Tsitsimpikou, Christina; Darviri, Christina; Kouretas, Demetrios; Bacopoulou, Flora

doi:10.1016/j.fct.2022.112901

Cited by 20 publications

(37 citation statements)

References 97 publications

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“…Among plasma micronutrients, 6 were selected with regard to their potential importance based on knowledge from previous pathophysiological studies: minerals zinc, selenium, copper; and vitamins A, β-carotene, and E [ 25 , 26 , 27 , 28 , 29 ]. Only assays of the 94 patients whose samples have been collected during the first 15 days of hospitalization were considered for the analysis of the associations between plasma antioxidant or mineral micronutrients levels at hospital admission and COVID-19 severe forms and death.…”

Section: Methodsmentioning

confidence: 99%

Minerals and Antioxidant Micronutrients Levels and Clinical Outcome in Older Patients Hospitalized for COVID-19 during the First Wave of the Pandemic

et al. 2023

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Excessive inflammatory response has been implicated in severe respiratory forms of coronavirus disease 2019 (COVID-19). Trace elements such as zinc, selenium, and copper are known to modulate inflammation and immunity. This study aimed to assess the relationships between antioxidant vitamins and mineral trace elements levels as well as COVID-19 severity in older adults hospitalized. In this observational retrospective cohort study, the levels of zinc, selenium, copper, vitamin A, β-carotene, and vitamin E were measured in 94 patients within the first 15 days of hospitalization. The outcomes were in-hospital mortality secondary to COVID-19 or severe COVID-19. A logistic regression analysis was conducted to test whether the levels of vitamins and minerals were independently associated with severity. In this cohort (average age of 78 years), severe forms (46%) were associated with lower zinc (p = 0.012) and β-carotene (p < 0.001) concentrations, and in-hospital mortality (15%) was associated with lower zinc (p = 0.009), selenium (p = 0.014), vitamin A (p = 0.001), and β-carotene (p = 0.002) concentrations. In regression analysis, severe forms remained independently associated with lower zinc (aOR 2.13, p = 0.018) concentrations, and death was associated with lower vitamin A (aOR = 0.165, p = 0.021) concentrations. Low plasma concentrations of zinc and vitamin A were associated with poor prognosis in older people hospitalized with COVID-19.

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Section: Methodsmentioning

confidence: 99%

Minerals and Antioxidant Micronutrients Levels and Clinical Outcome in Older Patients Hospitalized for COVID-19 during the First Wave of the Pandemic

et al. 2023

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“…The present and future need for micronutrients for health cannot be written off even though their role in diseases is inconsistent. For instance, most diseases are due to micronutrient deficiencies, and their supplementation tends to alleviate the symptoms, if not the entire disease [15,83,90,92,95,96,135,136]. In another instance, the efficacy of mono and combined therapies with various drugs against diseases may not be successful if there are no adjuvants in micronutrients because their associated toxicities often stem from such treatments [137].…”

Section: Micronutrients and Disease Management: The Future Is Still B...mentioning

confidence: 99%

Exploring micronutrient supplements in disease conditions: are they effective?

Ekong,

Nwakanma,

Iniodu

2024

FNDS

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Nutrition is essential for the health and well-being of all living beings and is sourced from foods of different origins and types. Most importantly, the food must contain carbohydrates, proteins, fat, vitamins and minerals in a balanced form to achieve optimum benefits. Vitamins and minerals, also known as micronutrients, are characterised by their nature, quantity and role in normal metabolic activities. In humans, micronutrients are exclusively obtained from food or supplements. In addition, vitamin D3 is synthesized de novo with the aid of sunlight, while vitamins B and K are synthesized in the gut by the resident bacteria. Micronutrients play an important role in health and disease states and have become the most widely used dietary supplements in the world. However, how effective they are against diseases is controversial as conflicting reports continue to emerge, especially where insufficient data is available. This review highlights the important role of micronutrient supplements in the alleviation of communicable and non-communicable diseases. Data were retrieved from the literature in databases including African Journal Online, Google Scholar, PubMed and Web of Science, among others, with hits on nutrients, vitamins and mineral supplements: Only literature with relevant information from 1993-2023 (30 years) was considered. As important as these micronutrients are for health and their supplementations are generally beneficial, it is worthy of note that their role in the disease treatment is still limited by insufficient data.

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“…Furthermore, co-ligands including NO, CO, and H 2 S may strengthen the coronavirus impact against coronavirus. The interaction with spike protein and stopping RNA replication of coronavirus has a huge impact on the growth of anti-COVID agents [ 124 ]. Therefore, the use of Schiff base complexed metals in metallodrug-based design for the treatment of viral infection may be advantageous [ 125 , 126 ].…”

Section: Antiviral Schiff Basesmentioning

confidence: 99%

Promising Schiff bases in antiviral drug design and discovery

et al. 2023

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Emerging and re-emerging illnesses will probably present a new hazard of infectious diseases and have fostered the urge to research new antiviral agents. Most of the antiviral agents are analogs of nucleosides and only a few are non-nucleoside antiviral agents. There is quite a less percentage of marketed/clinically approved non-nucleoside antiviral medications. Schiff bases are organic compounds that possess a well-demonstrated profile against cancer, viruses, fungus, and bacteria, as well as in the management of diabetes, chemotherapy-resistant cases, and malarial infections. Schiff bases resemble aldehydes or ketones with an imine/azomethine group instead of a carbonyl ring. Schiff bases have a broad application profile not only in therapeutics/medicine but also in industrial applications. Researchers have synthesized and screened various Schiff base analogs for their antiviral potential. Some of the important heterocyclic compounds like istatin, thiosemicarbazide, quinazoline, quinoyl acetohydrazide, etc. have been used to derive novel Schiff base analogs. Keeping in view the outbreak of viral pandemics and epidemics, this manuscript compiles a review of Schiff base analogs concerning their antiviral properties and structural-activity relationship analysis.

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The prognostic role of micronutrient status and supplements in COVID-19 outcomes: A systematic review

Cited by 20 publications

References 97 publications

Minerals and Antioxidant Micronutrients Levels and Clinical Outcome in Older Patients Hospitalized for COVID-19 during the First Wave of the Pandemic

Minerals and Antioxidant Micronutrients Levels and Clinical Outcome in Older Patients Hospitalized for COVID-19 during the First Wave of the Pandemic

Exploring micronutrient supplements in disease conditions: are they effective?

Promising Schiff bases in antiviral drug design and discovery

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