The prognostic role of mid-range ejection fraction in ST-segment elevation myocardial infarction

Alkhalil, Mohammad; Kearney, Aileen; MacElhatton, Daniel; Fergie, Ruth; Dixon, Lana

doi:10.1016/j.ijcard.2020.07.001

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…A multicentre observational study showed a persistently impaired LVSD (ejection fraction less than 50%) in approximately 75% of patients who had LVSD after acute myocardial infarction [14]. Furthermore, LVSD secondary to CAD is associated with poor mortality and morbidity with a stepwise increase in the risk of malignant arrhythmia and heart failure proportionate to the reduction in ejection fraction [15,16]. Similar observations were evident in the ISCHEMIA trial and the primary endpoint of cardiovascular death, nonfatal MI, hospitalization or cardiac arrest over 4 years was higher in patients with heart failure or LVSD (≤35%) in comparison to patients without heart failure symptoms or LVSD (22.7% versus 12.3%, respectively) [11].…”

Section: Significance Of Left Ventricular Systolic Dysfunction In Pat...mentioning

confidence: 99%

Coronary revascularization in patients with left ventricle systolic dysfunction, current challenges and clinical outcomes

Abdalwahab¹,

Al‐Atta²,

Egred³

et al. 2022

Rev. Cardiovasc. Med.

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The effects of coronary revascularization in patients with left ventricle systolic dysfunction (LVSD) are not well studied. The decision about revascularization and its timing remain challenging, not only related to procedural risk, but also linked to other several limitations including assessment of ischemia, viability, and ability to predict LV recovery. The role of viability as a prognostic marker for patients with LVSD and its use as a therapeutic target remains debatable. In this article, we will review the role of LVSD in patients undergoing coronary revascularization alongside the role of ischemia and viability assessment. We will provide a review of the literature on the outcomes of coronary revascularization, both surgically and percutaneously, in patients with LVSD.

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Section: Significance Of Left Ventricular Systolic Dysfunction In Pat...mentioning

confidence: 99%

Coronary revascularization in patients with left ventricle systolic dysfunction, current challenges and clinical outcomes

Abdalwahab¹,

Al‐Atta²,

Egred³

et al. 2022

Rev. Cardiovasc. Med.

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“…We are delighted to read the innovative article written by Alkhalil M and his colleagues examining mid-range ejection fraction (mrEF) in patients presented with ST segment elevation myocardial infarction (STEMI) [1] . Several critical issues should be further discussed to help the interpretation of the results.…”

Section: To the Editormentioning

confidence: 99%

Letter to the editor regarding “the prognostic role of mid-range ejection fraction in ST-segment elevation myocardial infarction”

Zhou

Zhang

Liu

2021

International Journal of Cardiology

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“…Additionally, hypertension, hyperglycemia, hyperlipidemia, obesity, elevated pro-inflammatory cytokines, chronic kidney impairment, and other cardiometabolic risk factors seem to be linked with many of these processes, thus increasing the risk of vascular instability and atherosclerosis [ 2 , 5 , 6 , 9 ]. It is well documented that the ventricular systolic dysfunction during ACS is an important clinical manifestation leading to worse outcomes [ 10 – 12 ]. On the other hand, it is worth noting that left ventricular ejection fraction (LVEF), determined by echocardiography, could be applied to clarify left ventricular systolic dysfunction (LVSD).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cardiometabolic risk markers linked to reduced left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI)

Mahdavi-Roshan

Ghorbani

Gholipour

et al. 2022

BMC Cardiovasc Disord

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Background It is well established that left ventricular systolic dysfunction (LVSD), as marked by reduced left ventricular ejection fraction (LVEF), notably worsens the prognosis of ST-elevation myocardial infarction (STEMI). However, the link between cardiometabolic risk markers and LVSD seems unclear. This study aimed to investigate the differences in variables affecting reduced LVEF in STEMI patients. Methods In the current retrospective study, 200 consecutive STEMI patients were enrolled between April 2016 to January 2017. Analysis of serum parameters, anthropometric evaluation, and echocardiography was performed after admission. The participants were categorized according to LVEF levels as follows: group1 (normal: 50–70%, n = 35), group2 (mildly reduced: 40–49%, n = 48); group3 (moderately reduced: 30–39%, n = 94) and group4 (severely reduced: < 30%, n = 23). Between-group comparisons were made using the Kruskal–Wallis test. Results Overall, of 200 STEMI patients with a mean age of 62 years, 27%(n = 54) were females. The median of BMI of patients in group4 (31.07 kg/m2) was significantly higher than group3 (26.35 kg/m2), group2 (25.91 kg/m2), and group1 (24.98 kg/m2; P value < 0.0001). Group4 patients showed significantly increased fasting blood sugar (FBS) than groups 1 (212.00, vs. 139.00 mg/dl; P value = 0.040). Patients in groups 1 and 2 exerted significantly elevated triglyceride levels than those in group4 (142.00, 142.50, and 95.00 mg/dl; P value = 0.001). WBC count, neutrophil%, and neutrophil to lymphocyte ratio among those in group1 (10,200/m3, 70.00%, and 2.92, respectively) were significantly lower than group4 (12,900/m3, 83.00%, and 5.47, respectively; P value < 0.05). Conclusion These findings highlight higher BMI, FBS, and leucocyte count linked to LVSD, probably through increasing the inflammation and reducing LVEF levels. More extensive studies are needed to clarify the clinical relevance of these results.

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The prognostic role of mid-range ejection fraction in ST-segment elevation myocardial infarction

Cited by 13 publications

References 26 publications

Coronary revascularization in patients with left ventricle systolic dysfunction, current challenges and clinical outcomes

Coronary revascularization in patients with left ventricle systolic dysfunction, current challenges and clinical outcomes

Letter to the editor regarding “the prognostic role of mid-range ejection fraction in ST-segment elevation myocardial infarction”

Evaluation of cardiometabolic risk markers linked to reduced left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI)

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