The prognostic role of pre-cystectomy thrombocytosis in invasive bladder cancer

Chakra, Mohamed Abou; Azoulai, David; Moussa, Mohamad; Ismail, Khadija; Peyromaure, Michaël; Delongchamps, Nicolas Barry; Saighi, D.; Bailly, Hugo; Duquesne, Igor

doi:10.1007/s11255-022-03346-7

Cited by 6 publications

(3 citation statements)

References 26 publications

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“… 43 , 44 Among various malignant tumors, elevated platelets have a strong correlation with low survival rates. 45–47 However, it is important to note that platelet count can be influenced by both apoptosis and production. Therefore, a normal platelet count may not necessarily indicate the absence of a pro-inflammatory cancer phenotype, as compensatory mechanisms can mask its presence.…”

Section: Discussionmentioning

confidence: 99%

A Nomogram Based on Platelet Distribution Width-to-Lymphocyte Ratio to Predict Overall Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

Wang,

Zhao,

Liang

et al. 2024

JIR

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Section: Discussionmentioning

confidence: 99%

A Nomogram Based on Platelet Distribution Width-to-Lymphocyte Ratio to Predict Overall Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

Wang,

Zhao,

Liang

et al. 2024

JIR

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“…Previous studies, with limited patients' number, showed that PTC in patients with bladder carcinoma is significantly associated with poor prognosis for survival. 4,[12][13][14] The prognostic effect of PTC in BC patients has not been evaluated completely.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies, with limited patients' number, showed that PTC in patients with bladder carcinoma is significantly associated with poor prognosis for survival 4,12–14 …”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic impact of preoperative thrombocytosis in muscle invasive bladder cancer: Any role in clinical practice?

Sretenovic,

Bojanic,

Grozdic Milojevic

et al. 2023

J of Clinical Ultrasound

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BackgroundSince earlier research suggested a link between preoperative thrombocytosis and poor oncological outcomes in several cancers, the significance of platelet count abnormalities in bladder carcinoma (BC) demands for further investigation.ObjectiveTo assess the prognostic value of preoperative thrombocytosis (PTC) on survival in patients with bladder carcinoma treated by radical cystectomy (RC).Patients and MethodsAnalytical cohort comprised a single‐center series of 299 patients who underwent RC for bladder carcinoma was evaluated. A platelet count beyond the threshold of 400 × 109/L was considered thrombocytosis. Along with the Kaplan–Meier survival probability, cox proportional hazard regression models were used.ResultsTwenty‐eight (9.4%) patients had preoperative thrombocytosis. PTC was associated with gender, tumor stage, tumor grade, lymphovascular invasion, hydronephrosis, anemia (p < 0.001), and hypoalbuminemia (p < 0.001). Preoperative thrombocytosis was strongly linked to worse overall survival (OS) (p = 0.002), and cancer specific survival (CSS) (p = 0.004), according to the Kaplan–Meier method. Throughout the follow‐up, a total of 198 (66.2%) patients died, including 170 (56.9%) from BC. For this study population 5‐year CSS was 45.8%. Preoperative thrombocytosis was not independently associated with OS (HR 1.168; 95% CI 0.740–1.844; p = 0.504) or CSS (HR 1.060; 95% CI 0.649–1.730; p = 0.816) in multivariate Cox regression analysis. Only tumor stage (HR 2.558; 95% CI 1.675–3.908; p < 0.001), hydronephrosis (HR 1.614; 95% CI 1.173–2.221; p = 0.003), lymph node metastasis (HR 1.555; 95% CI 1.076–2‐2.248; p = 0.019), anemia (HR 1.454; 95% CI 1.034–2.046; p = 0.032) and ASA grade (HR 1.375; 95% CI 1.006–1.879; p = 0.046) were independently associated with CSS.ConclusionsIn a single‐center study of consecutive patients who underwent radical cystectomy for bladder cancer, preoperative thrombocytosis was unable to predict outcomes.

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Preoperative platelet count as an independent predictor of long‐term outcomes among patients undergoing resection for intrahepatic cholangiocarcinoma

Chatzipanagiotou,

Tsilimigras,

Catalano

et al. 2024

Journal of Surgical Oncology

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Background and ObjectivesAn elevated platelet count may reflect neoplastic and inflammatory states, with cytokine‐driven overproduction of platelets. The objective of this study was to evaluate the prognostic utility of high platelet count among patients undergoing curative‐intent liver surgery for intrahepatic cholangiocarcinoma (ICC).MethodsAn international, multi‐institutional cohort was used to identify patients undergoing curative‐intent liver resection for ICC (2000–2020). A high platelet count was defined as platelets >300 *109/L. The relationship between preoperative platelet count, cancer‐specific survival (CSS), and overall survival (OS) was examined.ResultsAmong 825 patients undergoing curative‐intent resection for ICC, 139 had a high platelet count, which correlated with multifocal disease, lymph nodes metastasis, poor to undifferentiated grade, and microvascular invasion. Patients with high platelet counts had worse 5‐year (35.8% vs. 46.7%, p = 0.009) CSS and OS (24.8% vs. 39.8%, p < 0.001), relative to patients with a low platelet count. After controlling for relevant clinicopathologic factors, high platelet count remained an adverse independent predictor of CSS (HR = 1.46, 95% CI 1.02–2.09) and OS (HR = 1.59, 95% CI 1.14–2.22).ConclusionsHigh platelet count was associated with worse tumor characteristics and poor long‐term CSS and OS. Platelet count represents a readily‐available laboratory value that may preoperatively improve risk‐stratification of patients undergoing curative‐intent liver resection for ICC.

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The prognostic role of pre-cystectomy thrombocytosis in invasive bladder cancer

Cited by 6 publications

References 26 publications

A Nomogram Based on Platelet Distribution Width-to-Lymphocyte Ratio to Predict Overall Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

A Nomogram Based on Platelet Distribution Width-to-Lymphocyte Ratio to Predict Overall Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

Diagnostic and prognostic impact of preoperative thrombocytosis in muscle invasive bladder cancer: Any role in clinical practice?

Preoperative platelet count as an independent predictor of long‐term outcomes among patients undergoing resection for intrahepatic cholangiocarcinoma

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