The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: A meta-analysis

Zhou, Changjiang; Sun, Baochun

doi:10.1016/j.oraloncology.2014.08.018

Cited by 68 publications

(63 citation statements)

References 24 publications

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“…This finding was consistent with a previously studied cohort of OSCC obtained from a different region in Germany (26). A recent meta analysis concluded that, in the head and neck region, ALDH1A1 expression was highly correlated with tumor differentiation and lymph node metastasis, but not significantly with T stage (32). A correlation of higher ALDH1A1 expression with decreased OS and disease-free survival time was also presented.…”

Section: A B C Dsupporting

confidence: 91%

Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time

et al. 2016

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Abstract. Despite the development of novel multimodal treatment combinations in advanced oropharyngeal squamous cell carcinoma (OSCC), outcomes remain poor. The identification of specifically validated biomarkers is required to understand the underlying molecular mechanisms, to evaluate treatment efficiency and to develop novel therapeutic targets. The present study, therefore, examined the presence of aldehyde dehydrogenase family 1 member A1 (ALDH1A1) and high mobility group box 1 (HMGB1) expression in primary OSCC and analyzed the impact on survival time. In 59 patients with OSCC, the expression of ALDH1A1, p16 and HMGB1, and their clinicopathological data were analyzed. HMGB1 positivity was significantly increased in patients with T1-2 stage disease compared with T3-4 stage disease (P<0.001), whereas ALDH1A1 positivity was not. ALDH1A1 + tumors showed significantly lower differentiation than ALDH1A1 -tumors (P=0.018). Multivariate analysis showed that ALDH1A1 positivity (P=0.041) and nodal status (N2-3) (P=0.036) predicted a poor prognosis. In this patient cohort, ALDH1A1 and nodal status were identified as independent predictors of a shorter overall survival time. The study results, therefore, provide evidence of the prognostic value of ALDH1A1 as a marker for cancer stem cells and nodal status in OSCC patients. IntroductionHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with an annual incidence of 500,000 new cases and 200,000 mortalities (1,2). Oropharyngeal squamous cell carcinoma (OSCC) is a subtype of HNSCC arising from the oropharynx, which includes anatomically the base-of-the tongue, the tonsils, the soft palate and the side and back wall of the throat. The incidence rates for cancer sites in the oropharynx, such as the tonsils and the base of the tongue, are associated with a rise in human papilloma virus (HPV) infections, but a decreased number of tobacco-and alcohol-related cancers (3). In recent decades, there have been a number of important advances in the standard treatment of HNSCC, including surgical innovations for early-stage tumor patients and novel multimodal treatment combinations for more advanced-stage tumors, such as surgery followed by adjuvant radiotherapy (RT) or chemoradiotherapy (CRT), or CRT alone (4). However, outcomes remain poor in advanced tumor stages due to frequent local and regional metastases, and resistance to therapy (5,6). Therefore, identification of specific validated biomarkers is required to understand the underlying molecular mechanisms, evaluate treatment efficiency and develop novel therapeutic targets.High mobility group box 1 (HMGB1) is a nuclear, non-histone, chromatin-binding protein (7) that has been implicated in the activities of various cell type, including enterocytes, cardiomyocytes, pituicytes, macrophages and monocytes (8-11). HMGB1 is defined as one of the damage-associated molecular pattern molecules that interact with a variety of pattern recognition receptors in the microenvironment of damaged or necrot...

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Section: A B C Dsupporting

confidence: 91%

Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time

et al. 2016

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“…Aldehyde dehydrogenase 1 (ALDH1) is a detoxifying enzyme responsible for the oxidation of intracellular aldehydes and has emerged as an ideal marker for isolation of stem-like cells from heterogeneous tumors (32)(33)(34)(35). As the ALDH activity is increased in cancer stem cell populations isolated from multiple myeloma, acute myeloid leukemia (15), breast cancer lung, head and neck, gastric and colorectal cancers and recently in prostate cancer (36)(37)(38)(39)(40)(41)(42)(43)(44)(45), it is therefore considered as a reliable marker for isolation of cancer stem cells. Importantly, isolated ALDH high stem-like prostate cancer cells initiate growth of tumors in orthotopic mouse models (40).…”

Section: Introductionmentioning

confidence: 99%

Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow

et al. 2016

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Bone metastasis is a leading cause of morbidity and mortality in prostate cancer. While cancer stem-like cells have been implicated as a cell of origin for prostate cancer metastasis, the pathways that enable metastatic development at distal sites remain largely unknown. In this study, we illuminate pathways relevant to bone metastasis in this disease. We observed that cyclin A1 (CCNA1) protein expression was relatively higher in prostate cancer metastatic lesions in lymph node, lung, and bone/bone marrow. In both primary and metastatic tissues, cyclin A1 expression was also correlated with aromatase (CYP19A1), a key enzyme that directly regulates the local balance of androgens to estrogens. Cyclin A1 overexpression in the stem-like ALDH high subpopulation of PC3M cells, one model of prostate cancer, enabled bone marrow integration and metastatic growth. Further, cells obtained from bone marrow metastatic lesions displayed self-renewal capability in colonyforming assays. In the bone marrow, cyclin A1 and aromatase enhanced local bone marrow-releasing factors, including androgen receptor, estrogen and matrix metalloproteinase MMP9 and promoted the metastatic growth of prostate cancer cells. Moreover, ALDH high tumor cells expressing elevated levels of aromatase stimulated tumor/host estrogen production and acquired a growth advantage in the presence of host bone marrow cells. Overall, these findings suggest that local production of steroids and MMPs in the bone marrow may provide a suitable microenvironment for ALDH high prostate cancer cells to establish metastatic growths, offering new approaches to therapeutically target bone metastases. Cancer Res; 76(8); 2453-64. Ó2016 AACR.

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“…It is associated with abnormal and uncontrolled cell growth. 1 Oral cancer is the sixth most common cancer affecting mankind, which also presents with low rate of survival. More than 90% of oral cancers are histopathogically squamous cell carcinomas (SCC).…”

Section: Introductionmentioning

confidence: 99%

Effect of Ocimum sanctum on Oral Cancer Cell Line: An in vitro Study

Shivpuje¹,

Ammanangi²,

Bhat³

et al. 2015

The Journal of Contemporary Dental Practice

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Background: Cancer till today remains the leading cause of death in both developed and developing countries. Plants have been beacon of therapeutic sources for curing diseases from times immemorial. Hence, the present study aimed at evaluating the antiproliferative activity of extract of Ocimum sanctum leaves on oral cancer cell line. Objectives:• Clinical significance: Ocimum sanctum herb which is abundantly grown in India can be used for its anticancer properties for treating oral cancer. This will not only be cost-effective but will also have less or no side effects.

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The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: A meta-analysis

Cited by 68 publications

References 24 publications

Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time

Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time

Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow

Effect of Ocimum sanctum on Oral Cancer Cell Line: An in vitro Study

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