The prognostic role of tumor size in stage T1 gastric cancer

Chen, Yan; Jia, Yukun; Peng, Zhan; Wang, Guangye

doi:10.1186/s12957-022-02596-0

Cited by 11 publications

(11 citation statements)

References 32 publications

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“…We only performed TLDG in patients with clinically early gastric cancer, with the majority of cases in cT1 and the cT2 stage (94.5%) and endoscopic tumor size principally < 3 cm (66.3%). Yan Chen et al's study on the early gastric cancer patient group also recorded similar results [3]. Tumor size has been evaluated by many authors as a crucial factor in predicting postoperative stage and long-term outcomes after gastric cancer surgery [3,4].…”

Section: Discussionmentioning

confidence: 78%

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Short-Term Outcome of Laparoscopic Distal Gastrectomy With Intracorporeal Anastomosis for the Treatment of Gastric Cancer at Vietnam National Cancer Hospital

Pham

Nguyen

Thai

et al. 2023

jmpm

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Objectives: To describe the clinical, paraclinical characteristics and the short-term results of laparoscopic distal gastrectomy with intracorporeal anastomosis for the treatment of stomach cancer. Subjects and methods: A descriptive and retrospective study on 109 patients undergoing laparoscopic distal gastrectomy with intracorporeal anastomosis at Vietnam National Cancer Hospital between January 2019 and July 2022. Results: Patients were mostly men, > 50 years old. Duration of symptom onset to hospital admission ≤ 3 months and epigastric abdominal pain were the most common symptoms. The average surgery duration was 202 minutes, 90.8% of the patients had Billroth I anastomosis (Delta shaped). Post-operative outcomes recorded very few complications, with a fast recovery time. Conclusion: Laparoscopic distal gastrectomy with intracorporeal anastomosis is a minimally invasive surgical method with a safe early result and fast post-operative recovery time.

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Section: Discussionmentioning

confidence: 78%

“…Yan Chen et al's study on the early gastric cancer patient group also recorded similar results [3]. Tumor size has been evaluated by many authors as a crucial factor in predicting postoperative stage and long-term outcomes after gastric cancer surgery [3,4].…”

Section: Discussionmentioning

confidence: 78%

Short-Term Outcome of Laparoscopic Distal Gastrectomy With Intracorporeal Anastomosis for the Treatment of Gastric Cancer at Vietnam National Cancer Hospital

Pham

Nguyen

Thai

et al. 2023

jmpm

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show abstract

“…Furthermore, there were a few researchers studied the predicting value of tumor size was influenced by T stage in colon cancer, esophageal cancer and gastric cancer [ 6 , 29 – 31 ]. Dai et al found in colon cancer that when T stage increased, the influence of tumor size on death and recurrence risk decreases gradually [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Zhang et al found in esophageal cancer that tumor size had the strongest effect on prognosis for T1 classification and the weakest effect for T4 classification [ 30 ]. Chen et al declared that tumor size showed superior the discriminatory ability at T1 stage [ 31 ]. While Chen et al only take a few factors into analyses and didn’t mention the clinical significance based on DCA curves.…”

Section: Discussionmentioning

confidence: 99%

Tumor size as a significant prognostic factor in T1 gastric cancer: a Surveillance, Epidemiology, and End Results (SEER) database analysis

et al. 2023

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Background It has previously been observed that the prognostic value of tumor size varied according to different stages patients enrolled in gastric cancer. We aimed to investigate the influence of T stage on the prognostic and predicting value of tumor size. Material and methods A total of 13,585 patients with stage I–III gastric cancer were selected from the Surveillance, Epidemiology, and End Results Program (SEER) database. Univariate and multivariate cox regression analysis stratified by T stage were performed. C-index and time-dependent receiver operating characteristic curve (ROC) curve were applied to assess discrimination ability of tumor size and other factors. Nomograms were constructed to further assess the performance of tumor size in a specific model. Calibration ability, discrimination ability, reclassification ability and clinical benefits were executed to judge the performance of models. Results Stratified analyses according to T stage illustrated that with the increase of T stage, the effect of tumor size on overall survival (OS) and cancer-specific survival (CSS) significantly decreased. Moreover, tumor size showed superior discrimination ability in T1 gastric cancer, outperformed other prognostic factors in predicting both CSS (C-index: 0.666, AUC: 0.687) and OS (C-index: 0.635, AUC: 0.660). The cox regression model included tumor size showed better performance than the model excluded tumor size in every aspect. Conclusion T stage had a negative impact on the predicting value of tumor size. Tumor size showed significant prognostic value in T1 gastric cancer, which may be effective in clinical practice.

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“…Chen et al reported that tumor size can be included in AJCC staging, considering that it may have different prognostic roles in gastric cancer at different stages (6). In some series, it has been shown that MLN size is effective in the determination of the prognosis and it provides valuable support to the classification systems in patients with gastrointestinal malignancies, including colon and esophageal cancer (7,8).…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of the largest histopathological metastatic lymph node size for postoperative course of patients undergoing surgery for gastric cancer

Ömeroğlu

Gülmez²,

Yazici³

et al. 2023

Front. Surg.

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AimThe aim of this study was to investigate the effect of the largest metastatic lymph node (MLN) size on postoperative outcomes of patients with stage II-III gastric cancer (GC).MethodsA total of 163 patients with stage II/III GC who underwent curative surgery were included in this single-center retrospective study. The lymph nodes were counted, each lymph node was analyzed for metastatic involvement by histopathological examination, and the diameter of the largest metastatic lymph node was recorded. The severity of postoperative complications was assessed by Clavien–Dindo classification system. Two groups of 163 patients were defined according to ROC analysis with cut-off value of histopathologically maximum MLN diameter. A comparative analysis of demographic and clinicopathological characteristics of the patients and their postoperative outcomes were performed.ResultsThe median hospital stay was significantly longer in patients with major complications compared to patients without major complications [18 days (IQR: 13–24) vs. 8 days (IQR: 7–11); (p < 0.001)]. The median MLN size was significantly larger in deceased patients compared to survived [1.3 cm (IQR: 0.8–1.6) vs. 0.9 cm (IQR: 0.6–1.2), respectively; (p < 0.001)]. The cut-off value of MLN size predicting mortality was found as 1.05 cm. MLN size ≥1.05 cm had nearly 3.5 times more negative impact on survival.ConclusionsThe largest metastatic lymph node size had a significant association with survival outcomes. Particularly, MLN size over 1.05 cm was associated with worse survival outcomes. However, the largest MLN was not shown to have any effect on major complications. Further prospective and large-scale studies are required to draw more precise conclusions.

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The prognostic role of tumor size in stage T1 gastric cancer

Cited by 11 publications

References 32 publications

Short-Term Outcome of Laparoscopic Distal Gastrectomy With Intracorporeal Anastomosis for the Treatment of Gastric Cancer at Vietnam National Cancer Hospital

Short-Term Outcome of Laparoscopic Distal Gastrectomy With Intracorporeal Anastomosis for the Treatment of Gastric Cancer at Vietnam National Cancer Hospital

Tumor size as a significant prognostic factor in T1 gastric cancer: a Surveillance, Epidemiology, and End Results (SEER) database analysis

Clinical significance of the largest histopathological metastatic lymph node size for postoperative course of patients undergoing surgery for gastric cancer

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