Abstract:The gain or amplification 1q21(1q21+) is the most common abnormality in multiple myeloma, but their prognostic impact remains under debate in the era of novel agents. In addition, the prognosis of the 1q21 copy number is controversial. In this retrospective study, cytogenetic abnormalities detected by fluorescence in situ hybridization (FISH) and clinical outcomes of 375 newly diagnosed MM patients were analyzed. 1q21 + was detected in 164 (43.7%) patients, including 103 (27.5%) with 3 copies and 61(16.3%) wit… Show more
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