The Prognostic Significance of HALP Index for Colon Cancer Patients in a Hispanic-Based Population

Abstract

Background. Survival and recurrence rates following locoregional colon cancer surgical resection are highly variable. Currently used tools to assess patient risk are still imperfect. In the present work, we evaluate, for the first time, the prognostic value of the recently developed HALP (hemoglobin, albumin, lymphocyte, and platelet) index in Hispanic colon cancer patients. Patients and Methods. We conducted a retrospective cohort study in Mexican patients with a nonmetastatic colon cancer diagnosis who underwent surgical resection. We determined the preoperative HALP score optimal cut-off value by using the X-tile software. We plotted survival curves using the Kaplan–Meier method and performed a multivariate Cox regression analysis to explore the association of preoperative HALP score with two primary endpoints: overall survival (OS) and disease-free survival (DFS). Results. We included 640 patients (49.8% female). The optimal HALP cut-off value was 15.0. A low HALP index was statistically significantly associated with a higher TNM stage. Low HALP score was statistically significantly associated with shorter median OS in the Kaplan–Meier analysis (73.5 vs. 84.8 months) and in the multivariate Cox regression analysis (HR = 1.942, 95% CI = 1.647–2.875). There was no significant association between the HALP score and DFS. Conclusions. Our findings show that the HALP index is an independent factor associated with survival in Hispanic patients, despite recurrence. It seems to reflect both the anatomical extent of the disease and traditionally unaccounted nutritional and inflammatory factors that are significant for prognosis.

The relationship between preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) score and right colon cancer surgery outcomes: a retrospective cohort study

“…The current research explores the association between HALP score and colorectal cancer, primarily focusing on overall survival and disease-free survival outcomes [10,24,25]. Research studies have demonstrated that when the HALP score above a specific threshold, there is a correlation with improved survival outcomes [24][25][26]. In our study, we endeavored to examine the correlation between the HALP score and perioperative morbidity in the context of right colon surgery.…”

Clinical value of hemoglobin, albumin, lymphocyte, and platelet indexes in predicting lymph node metastasis and recurrence of endometrial cancer: a retrospective study

“…Systemic inflammation stimulates angiogenesis, immunosuppression and supports the formation of microenvironment, thus promoting the initiation, progression and metastasis of tumor cells ( Calderillo Ruiz et al, 2022 ). Recently, research has focused on the impact of nutritious status on a cancer patient’s prognosis.…”

Diagnostic Value of HALP Score in Detecting Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus

“…HALP score has been used by many researchers to predict the prognosis in several types of cancers for the last few years. [6][7][8] Hb and albumin can reflect the nutritional status of the patient and albumin alone has been considered as a positive prognostic factor for cancer patients. Lymphocyte and platelet values can give a hint of the patients' immune status; already included in scores like platelet-to-lymphocyte ratio.…”