The prognostic significance of preoperative serum cancer antigen 15-3 levels in endometrial carcinomas

Taş, Emre Erdem; Yavuz, Ayşe Filiz

doi:10.15537/smj.2017.11.20479

Cited by 4 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CA15.3 levels significantly correlated with prognostic factors and were a useful prognostic tool for endometrial (uterine) cancer (55) . However, whether equol impacts the initiation and development of endometrial cancer by affecting the level of CA15.3 needs further research verification.…”

Section: Discussionmentioning

confidence: 98%

“…We further analysed the correlation between CA15.3 and urinary equol in twenty-four HRC patients by cancer type and found that there was a discrepant correlation in the various cancers (for breast cancer: n 16, r = 0·420, P = 0·119; for uterine cancer: n 7, r = 0·843; P = 0·035; data not shown). Studies have suggested that CA15.3 levels significantly correlated with prognostic factors and were a useful prognostic tool for endometrial (uterine) cancer (55) . However, whether equol impacts the initiation and development of endometrial cancer by affecting the level of CA15.3 needs further research verification.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999–2010

et al. 2022

View full text Add to dashboard Cite

Phytoestrogens may have potential effects on hormone-related cancers (HRCs) and cancer biomarkers, but the findings have been inconsistent so far. Participants from the National Health and Nutrition Examination Survey 1999-2010 with information on the levels of urinary phytoestrogens, serum cancer biomarkers and cancer history were included. Sampling-weighted logistic regression models examined the association between urinary phytoestrogens concentrations (creatinine-standardized and log-transformed) and HRCs, followed by stratified analyses by race/ethnicity, age and menopausal status for different gender. Correlation analyses between phytoestrogens and cancer biomarkers were performed. Of the total 8,844 participants, there were 373 with HRCs. We observed total isoflavone and enterodiol excretion was positively associated with HRCs, especially in non-Hispanic white female subpopulations (Ptrend <0.05). Similar association also existed in the total isoflavones and enterodiol levels with breast cancer. Whereas, the highest concentration of total isoflavones was significantly linked to a reduced prevalence of HRCs (OR = 0.40, 95% CI: 0.19-0.84) in white males and of prostate cancer (OR = 0.40, 95% CI: 0.18-0.86). Among 24 participants with HRCs, urinary equol concentration was positively correlated with CA15.3. Also, an inverse correlation of total PSA and positive correlation of the PSA ratio with urinary enterolactone were detected in 13 prostate cancer patients. But no significant correlation was found in all normal subjects. Our findings indicated that higher concentrations of total isoflavones and enterodiol were positively associated with HRCs. Urinary certain phytoestrogen excretion may affect serum cancer biomarker levels in cancer patients. But further prospective studies are needed to provide stronger evidence.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999–2010

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In studies evaluating risk factors for LN metastasis in patients with EC, the parameters that are considered as negative prognostic factors for EC are also indicated as risk factors for LN metastasis (6)(7)(8)(14)(15)(16). However, there is no consistency between the results of similar studies.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, there is no definite method to detect the presence of LN metastases preoperatively or intraoperatively (6)(7)(8)(9)(10)(11). For this reason, FIGO and "American Congress of Obstetricians and Gynecologists" recommend performing both pelvic and paraaortic LN sampling in surgical staging of patients with EC (12).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Risk Factors for Lymph Node Metastasis in Endometrial Cancer

Taş¹,

Akçay²,

Keskin³

et al. 2019

Istanbul Med J

View full text Add to dashboard Cite

Amaç: Endometriyum kanseri nedeni ile evreleme operasyonu yapılan olgularda lenf nodu (pelvik ve/veya paraaortik lenf nodları) metastazı için risk oluşturan klinik ve patolojik faktörlerin belirlenmesidir. Yöntemler: Çalışmamızda 2007-2016 yılları arasında endometriyum kanseri tanısı ile evreleme cerrahisi uygulanan 143 olgunun klinik ve patolojik özellikleri retrospektif olarak incelendi. Lenf nodu metastazı için risk faktörlerinin belirlenmesinde doğrusal regresyon analizi, lojistik regresyon analizi, Spearman korelasyon testi ve işlem karakteristik eğrisi testleri kullanıldı. Tüm istatistiksel değerlendirmeler için p<0,05 anlamlı kabul edildi. Bulgular: Beş olguda (%3,5) sadece pelvik, 3 olguda (%2,1) sadece paraaortik, 5 olguda (%3,5) ise hem pelvik hem de paraaortik lenf nodu olmak üzere 13 olguda (%9,1) lenf nodu metastazı mevcuttu. Doğrusal regresyon analizinde non-endometrioid histolojik tip, derin miyometrial invazyon (≥%50 invazyon derinliği), ileri histolojik grade, lenfovasküler alan invazyonu, pozitif peritoneal sitoloji ve tümör boyutu ile lenf nodu metastazı arasında anlamlı ilişki bulundu (p<0,05). Tümör boyutu ile lenf nodu metastazı arasında pozitif korelasyon mevcuttu ve işlem karakteristik eğrisinde 4,25 cm tümör boyutu lenf nodu metastazı için en uygun sınır değer olarak tespit edildi (duyarlılık %83, özgüllük %75). Regresyon analizinde ise lenfovasküler alan invazyonu lenf nodu metastazı için bağımsız tek risk faktörü olarak belirlendi (odss oranı: 11,8; %95 güven aralığı: 1,8-75,4; p=0,009). Sonuç: Endometriyal kanserli olgularda lenfovasküler alan invazyonu lenf nodu metastazı için bağımsız tek risk faktörüdür. Tümör boyutu ile lenf nodu metastazı arasındaki korelasyon ise doğrusaldır. Lenf nodu metastazı için tümör boyutunun sınır değerini belirlemede yeni çalışmalara ihtiyaç vardır. Anahtar Kelimeler: Endometriyal karsinoma, lenfatik metastaz, lojistik model Introduction: To determine the clinical and pathologic factors that are risk factors for metastasis of the lymph nodes (pelvic and/or aortic lymph nodes) in cases who underwent staging surgery due to endometrial carcinoma. Methods: The clinical and pathological characteristics of 143 patients who underwent staging surgery between 2007 and 2016 were retrospectively analyzed. Linear regression analysis, logistic regression analysis, Spearman correlation and Receiver operator curve tests were used to determine risk factors for lymph node metastasis. P<0.05 was considered significant in all statistical evaluations. Results: Thirteen cases (9.1%) had lymph node metastasis [5 cases (3.5%) only pelvic, 3 cases (2.1%) only paraaortic, 5 cases (3.5%) both pelvic and paraaortic lymph node]. In linear regression analysis, there was a significant correlation between lymph node metastasis and non-endometrioid histological type, deep myometrial invasion (≥50% invasion depth), advanced histologic grade, lymphovascular space invasion, positive peritoneal cytology and tumor size (p<0.05). The correlation between tumor size and lymph node metastasis w...

show abstract

“…The reduced hospital stay in TLH patients indicates lower cost and rapid recovery. (29) 1988 28 (31) 17 (11) Zorlu et al (30) 1994 2 ( 7) 1 (4) Larson et al (27) 1995 9 (24) 5 ( 14) Frumovitz et al (28) 2004 23 ( 27) 19 ( 23) Stephan et al (31) 2014 24 ( 29 Serum markers such as CA-125, CA-15-3, and CA-19-9 may be a useful to predict endometrial cancer preoperatively (40,41) . Panidis et al (6) reported that mean serum CA-125, CA-15-3, and CA-19-9 values were 56.8, 43.1, and 30.1, respectively.…”

Section: Discussionmentioning

confidence: 99%

Comparison of pre- and postoperative techniques in the assessment of histological tumor grading in patients with endometrial carcinoma: a descriptive cross-sectional study

Uzel¹,

Лахно²

2019

Curr Gynecol Oncol

View full text Add to dashboard Cite

This study aimed to compare histological grades in patients with endometrial cancer assessed by pre-and postoperative techniques. Methods: We retrospectively reviewed the records of 43 patients operated on for endometrial cancer between 2012 and 2019. The primary dependent variables included histological grade assessed by preoperative probe curettage and postoperative analysis of surgical specimens. The independent variables included age, surgery type (laparoscopy or laparotomy), pre-and postoperative hemoglobin levels, and the length of hospital stay. Results: The mean age was 62.14 ± 9.14 years, and the length of hospitalization time was 6.51 ± 3.46 days. The mean values of pre-and postoperative hemoglobin levels were 12.44 ± 1.51 mg/dL and 10.91 ± 1.28 mg/dL, respectively. According to the grading results of probe curettage, grade 1, 2, and 3 tumors were found in 21 (48.8%), 19 (44.2%), and 3 (7.0%) patients, whereas the paraffin sections revealed grade 1, 2, and 3 in 12 (27.9%), 22 (51.2%), and 9 (20.9%) patients, respectively. There was a fair but statistically significant agreement between the pre-and postoperative grading (kappa = 0.365, p = 0.001). Discussion: This study confirms literature reports that preoperative histological tumor grade fairly predicts final histological results. Caution is warranted when making clinical decisions solely based on probe curettage. Further improvements in preoperative diagnostic techniques in endometrial cancer are needed.

show abstract

The prognostic significance of preoperative serum cancer antigen 15-3 levels in endometrial carcinomas

Cited by 4 publications

References 20 publications

Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999–2010

Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999–2010

Assessment of Risk Factors for Lymph Node Metastasis in Endometrial Cancer

Comparison of pre- and postoperative techniques in the assessment of histological tumor grading in patients with endometrial carcinoma: a descriptive cross-sectional study

Contact Info

Product

Resources

About