The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer

Pretreatment Serum Levels of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein-3 in Men with Advanced Non-Small Cell Lung Cancer

“…In recent epidemiologic studies, relatively high plasma IGF-1 and low IGFBP-3 levels have been independently associated with greater risk of several malignancies including prostate cancer in men, breast cancer among premenopausal women, and colorectal neoplasms. 13,15,16 However it has been reported that the pattern of this association differs smoking-related cancers and the others. 13 Over the past decade, many studies have also provided evidence for relationship between IGF system and lung cancers.…”

“…13,15,16 However it has been reported that the pattern of this association differs smoking-related cancers and the others. 13 Over the past decade, many studies have also provided evidence for relationship between IGF system and lung cancers. 13,[17][18][19][20][21] In some of them, elevated IGF-1 and depressed IGFBP-3 levels were reported in lung cancers.…”

“…13,[17][18][19][20][21] In some of them, elevated IGF-1 and depressed IGFBP-3 levels were reported in lung cancers. 13,[17][18][19] On the other hand, some authors reported that mean serum levels were not significantly different between the case and the control groups. 20 In the present study, we found depressed IGF-1 and IGFBP-3 levels in the patients.…”

“…Several studies suggest that higher blood level of IGF-1 and/or lower blood levels of IGFBP-3 associated with an increased risk of various cancers including the lung cancers. 2,[6][7][8][9][10][11][12][13] The aim of this study was to investigate the clinical significance of IGF-1 and IGFBP-3 serum levels by comparing advanced NSCLC patients with healthy controls and to evaluate whether the levels of IGF-1 and IGFBP-3 would predict the outcome in these patients.…”

Expression and Clinical Significance of Insulin-Like Growth Factor 1 in Lung Cancer Tissues and Perioperative Circulation from Patients with Non-Small-Cell Lung Cancer

“…In accord with our previous research, immunologic and molecular analyses showed that igf-1 is produced in human lung parenchyma and lung cancer cell lines [9][10][11][12] and that igf-1 is an autocrine regulator for the brain-metastatic variants of human nsclc and small-cell lung cancer cell lines 10,11 . The significance of circulating igf-1 in the development of nsclc is not clear, and few studies have assessed the circulating level of igf-1 in patients undergoing surgical treatment for an existing lung cancer 13 .…”