The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer

Abstract

Abstract:Although PTP4A3 has been shown to be a very important factor in promoting cancer progression, the role of its close family member PTP4A2 is still largely unknown. Recent reports have shown contradicting results on the role of PTP4A2 in breast cancer progression. Considering this, we aimed to investigate the prognostic value of PTP4A2 in five independent breast cancer data sets (minimum 198 patients per cohort, totaling 1,124 patients) in the Gene Expression Omnibus Database. We found that high expression of PTP4A2 was a favorable prognostic marker in all five independent breast cancer data sets, as well as in the combined cohort, with a hazard ratio of 0.68 (95% confidence interval =0.56-0.83; P,0.001). Low PTP4A2 expression was associated with estrogen receptor-negative tumors and tumors with higher histological grading; furthermore, low expression was inversely correlated with the expression of genes involved in proliferation, including MKI67 and the MCM gene family encoding the minichromosome maintenance proteins. These findings suggest that PTP4A2 may play a role in breast cancer progression by dysregulating cell proliferation. PTP4A2 expression was positively correlated with ESR1, the gene encoding estrogen receptor-alpha, and inversely correlated with EGFR expression, suggesting that PTP4A2 may be involved in these two important oncogenic pathways. Together, our results suggest that expression of PTP4A2 is a favorable prognostic marker in breast cancer.

PTP4A2 regulates Sorafenib resistance via activating autophagy in hepatocellular carcinoma

“…Therefore, it will be meaningful to nd new biomarkers that can provide additional staging information to help select treatments and optimize treatment outcomes. Recent studies have noted that the expression of PTP4A2 is upregulated in several cancer types such as breast, colon and pancreatic cancer [19,20,21]. Consistent with these studies, we reported for the rst time that PTP4A2 expression was markedly upregulated in HCC tissues.…”

“…These data indicate that PTP4A2 can indirectly regulate the transcription level of RAB24. Histone modi cation is an important epigenetic mechanism that regulates gene expression (eg: histone acetylation and/or methylation), and plays an important role in cancer genesis [20,21]. Next, we explored whether histone acetylation or methylation status were affects by PTP4A2 in RAB24 promoter.…”

“…The functions of three closely related small PTPs (PTP4A1, PTP4A2 and PTP4P3) in tumor cells have attracted our attention, including promoting tumor migration, invasion and metastasis [15][16][17][18]. Recently, a growing body of reaserch has shown that, in several types of malignant tumors, the up-regulation of PTP4A2 expression was strongly related to cancer progression [19][20][21]. Currently, the participation of PTP4A2 and its signi cance of clinic/prognosis in HCC are uncertian.…”

Circular RNA hsa_circ_0007364 increases cervical cancer progression through activating methionine adenosyltransferase II alpha (MAT2A) expression by restraining microRNA-101-5p

“…Here, we identified a novel circRNA hsa_circ_0007364, derived from RNA cyclization following a head-to-tail splicing of exon 2 and exon 3 of PTP4A2 (protein tyrosine phosphatase 4A2). PTP4A2 has been reported to influence tumor progression and stem cell self-renewal [ 25–27 ]. Here, we found that hsa_circ_0007364 is remarkably overexpressed and correlates with advanced FIGO stage and lymph-node metastasis in CC patients.…”

PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS

“…Among the PRL family, PRL2 is the least studied member. While studies have reported that PRL2 is overexpressed in pancreatic, breast and lung cancer samples and its level is associated with tumor progression, there is still a lack of information available regarding the function of PRL2 ( 12 ). The expression of PRL2 is the most abundant of the three PRLs and PRL2 mRNA is almost ubiquitously expressed at high levels in normal adult human immune tissues, suggesting that PRL2 may have a specific role in immune function ( 13 ).…”