The prognostic significance of serial myoglobin, troponin I, and creatine kinase–MB measurements in patients evaluated in the emergency department for acute coronary syndrome

McCord, James; Nowak, Richard M.; Hudson, Michael; McCullough, Peter A.; Tomlanovich, Michael C.; Jacobsen, Gordon; Tokarski, Glenn; Khoury, Nabil; Weaver, W. Douglas

doi:10.1016/s0196-0644(03)00411-6

Cited by 47 publications

(19 citation statements)

References 23 publications

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“…Reported use of blood enzyme markers is common throughout the surgical literature [9,12,[16][17][18][20][21][22][23][24]. Rhabdomyolysis has numerous etiologies and includes local crush injury, vascular compromise, soft tissue infections, electrical injuries, excessive steroid use, seizures, surgery, and heat stroke [1,19,22].…”

Section: Discussionmentioning

confidence: 99%

“…The serum enzymes measured for our study have a circulating half-life of approximately 12 hours. Additionally, the use of measured cardiac proteins such as troponin I is specific for coronary injury and predicts adverse events after possible acute coronary syndrome [23]. For this study, we used troponin I to rule out any coronary injury that may confound our results.…”

Section: Discussionmentioning

confidence: 99%

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The Relationship Between Skeletal Muscle Serum Markers and Primary THA: A Pilot Study

Cohen

Katz

Skrepnik

2009

Clinical Orthopaedics &Amp; Related Research

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Various reports confirm elevations in serum markers associated with skeletal muscle injury after orthopaedic surgery in the absence of overt clinical manifestations of myocardial injury. We therefore measured the influence surgical approach has on these serum markers after primary THA. We nonrandomly enrolled 30 nonconsecutive patients undergoing THA in three groups of 10 based on current surgical approaches used at our facility: (1) minimally invasive (MIS) modified Watson Jones approach; (2) miniposterior transmuscular approach (MIS-I); and (3) MIS-II incision. Blood samples for hemoglobin, hematocrit, cardiac troponin I, total creatine kinase, creatine phosphokinase, and serum myoglobin were obtained the morning before surgery as a baseline, immediately postoperatively, and 72 hours thereafter. We found reproducible trends in serum enzyme levels consistent with skeletal muscle damage resulting from primary THA. Troponin I remained normal in all but one patient indicating no myocardial contribution to measured serum enzyme levels. All three procedures resulted in similar trends in serum enzyme markers relevant to primary THA. Our preliminary data suggest no surgical approach appears to affect the degree of muscle trauma more or less than another.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Relationship Between Skeletal Muscle Serum Markers and Primary THA: A Pilot Study

Cohen

Katz

Skrepnik

2009

Clinical Orthopaedics &Amp; Related Research

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“…Serum Mb, CK-MB, troponin I and troponin T have been used as diagnostic biochemical markers for cardiac contusion or myocardial infarction clinically. Elevated serum Mb, CK-MB, and troponin I and troponin T were detected in patients with early myocardial infarction [34][35][36][37][38] or cardiac contusion [7,10,[39][40][41][42]. In recent years, it is demonstrated that serum troponin I and troponin T are highly specific to myocardial injury, especially in the diagnosis of myocardial contusion as they are myocardial regulatory contractile proteins which are not found in skeletal muscles and are released into the circulation only after loss of membrane integrity in comparison with serum Mb and CK-MB [7,10,42].…”

Section: Discussionmentioning

confidence: 99%

Diverse morphological lesions and serious arrhythmias with hemodynamic insults occur in the early myocardial contusion due to blunt impact in dogs

Guan

Zhang

Zhao

et al. 2007

Forensic Science International

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“…The strategies of detection of acute and chronic myocardial infarction with the advent of the discovery of new markers are usually composed of electrocardiographic examination, cTnI and cTnT cardiac troponins, as well as other markers such as myoglobin, creatine kinase (CK), MB Creatine kinase (CK-MB), and more recently ischemiamodified albumin (IMA), which is a prognostic marker of cardiac lesions [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

The Recent Advances in the Serological Detection of Acute Myocardial Infarction

Gh¹,

Ac²

2016

Clin Med Biochemistry

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Acute Myocardial Infarction (AMI) is one of the leading causes of morbidity and mortality worldwide. The greatest risk of fatality occurs within the first hours of initiation of AMI. Thus, the early diagnosis of cardiac ischemia is fundamental for the effective management of AMI patients. Inadequate diagnosis of patients with chest pain often leads to inadequate admission of patients without AMI and vice versa. In addition to the clinical history, physical examination, accurate electrocardiogram findings, and evaluation of cardiac biomarkers play an important role in the early diagnosis of acute ischemia. The present review discusses in detail the various cardiac biomarkers released during the event of an AMI.

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The prognostic significance of serial myoglobin, troponin I, and creatine kinase–MB measurements in patients evaluated in the emergency department for acute coronary syndrome

Cited by 47 publications

References 23 publications

The Relationship Between Skeletal Muscle Serum Markers and Primary THA: A Pilot Study

The Relationship Between Skeletal Muscle Serum Markers and Primary THA: A Pilot Study

Diverse morphological lesions and serious arrhythmias with hemodynamic insults occur in the early myocardial contusion due to blunt impact in dogs

The Recent Advances in the Serological Detection of Acute Myocardial Infarction

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