The prognostic significance of surgical staging for carcinoma of the endometrium

Wolfson, Aaron H.; Sightler, Sterling E.; Markoe, Arnold M.; Schwade, James G.; Averette, H.E.; Ganjei, Parvin; Hilsenbeck, SG

doi:10.1016/0020-7292(93)90402-i

Cited by 21 publications

(30 citation statements)

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“…(1) One of the most important prognostic factors in endometrial cancer is lymph node metastasis. (2,3) Therefore, it is vital to develop new treatment modalities that focus on lymph node metastasis.…”

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Development of a mouse model for lymph node metastasis with endometrial cancer

et al. 2011

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Controlling lymph node metastasis is currently a key issue in cancer therapy. Lymph node metastasis is one of the most important prognostic factors in various types of cancers, including endometrial cancer. Vascular endothelial growth factor‐C (VEGF‐C) plays a crucial role in lymphangiogenesis, and is implicated to play an important role in lymph node metastasis. To evaluate the role of VEGF‐C in lymph node metastasis, we developed an animal model by using an endometrial cancer cell line, HEC1A. This cell line is not invasive by nature and secretes moderate amounts of VEGF‐C; intrauterine injection of HEC1A cells into Balb/c nude mice resulted in uterine cancer with lymph node metastasis after 8 weeks. To analyze the contribution of VEGF‐C to lymph node metastasis, its corresponding gene was stably introduced into HEC1A cells (HEC1A/VEGF‐C), which then produced more than 10 times the amount of VEGF‐C. The number of lymph node metastases was significantly higher in HEC1A/VEGF‐C cells than in HEC1A cells (3.2 vs 1.1 nodes/animal, respectively). Augmented lymphangiogenesis was observed within tumors when HEC1A/VEGF‐C cells were inoculated. These results indicate that VEGF‐C plays a critical role in lymph node metastasis, in addition to serving as a platform to test the efficacy of various therapeutic modalities against lymph node metastasis. (Cancer Sci 2011; 102: 2272–2277)

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Development of a mouse model for lymph node metastasis with endometrial cancer

et al. 2011

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“…1,3 In cancers of the endometrium, as with most malignant tumors of most organs, stage is the most powerful prognostic parameter. [4][5][6][7][8][9] The determination of the extent of anatomic spread of endometrial cancers has traditionally been achieved 'clinically'. Clinical staging entailed the use of various combinations of fractional curettage, uterine ultrasound and pelvic examination, as outlined in the 1971 annual report of the International Federation of Gynecology and Obstetrics (FIGO).…”

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Upstaging based solely on positive peritoneal washing does not affect outcome in endometrial cancer

et al. 2005

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Surgical staging of endometrial carcinoma includes the collection of peritoneal washings in the abdomen and pelvis. A positive finding upstages patients to International Federation of Gynecology and Obstetrics stage IIIA. However, the prognostic significance of such an upstaging, and thus the justification for the routine performance of this procedure, is unclear. This 5-year retrospective study was conducted to determine the frequency and prognostic significance of upstaging of endometrial carcinoma based solely on positive washings. The cohort for the study was collected by review of pathology reports of all washings that were performed prior to hysterectomies for suspected endometrial carcinomas over a 5-year period (01/1995-12/ 1999). Cases with positive cytology were selected if there was no grossly apparent intraperitoneal disease, no histologic evidence of extra-uterine tumor and the cases would otherwise have been considered stage I or II (case group). An age-matched control group was selected of stage I and II patients with the same histologic subtypes and negative washings (n ¼ 19). Of 220 endometrial carcinomas, peritoneal washing cytology was abnormal in 19 (8.6%) and was solely responsible for upstaging only 10 patients (4.5% of all cases, eightendometrioid, one-serous, one-mixed; nine stage IA or IB and one stage IIB). Adjuvant therapy was administered in 90% of the case group and 74% of the control group. After a median follow-up of 51 months (case group) and 63 months (control group), we found only a single patient with progression of disease (recurrence, metastases or death) in the control group. It is concluded that abnormal cytology without other evidence of extrauterine disease leads to upstaging of a minority of endometrial carcinoma patients (4.5%), but does not appear to affect their overall outcome. Although this is a small single site study, it raises questions about the value of this procedure in patients with endometrial cancer.

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“…15; 1 (15)(16)(17)(18)(19) Wszystkie chore otrzymały wysokodawkową brachyterapię (high dose rate -HDR ) -3 frakcje po 6,0 Gy aplikowane raz w tygodniu. Dawka została obliczona na 0,5 cm od powierzchni aplikatora o średnicy dostosowanej do anatomii pochwy pacjentki (2,0-4,0 cm).…”

Section: Charakterystyka Pacjentek I Leczeniaunclassified

Analysis of acute and late toxicity of adjuvant radiotherpy in women with cervical and endometrial cancer

Wareńczak-Florczak¹,

Roszak²,

Wlodarczyk³

et al. 2011

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The prognostic significance of surgical staging for carcinoma of the endometrium

Cited by 21 publications

References 0 publications

Development of a mouse model for lymph node metastasis with endometrial cancer

Development of a mouse model for lymph node metastasis with endometrial cancer

Upstaging based solely on positive peritoneal washing does not affect outcome in endometrial cancer

Analysis of acute and late toxicity of adjuvant radiotherpy in women with cervical and endometrial cancer

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