The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy

Li, Xiaoping; Luo, Rong; Rong-jian, Jiang; Kong, Hong Sik; Tang, Yijia; Shu, Yan; Hua, Wei

doi:10.1016/j.hrtlng.2014.03.001

Cited by 25 publications

(19 citation statements)

References 33 publications

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“…2a). Higher levels of cTnI were also observed in younger age groups (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) for both AA and AGA ( Fig. 2c).…”

Section: Higher Plasma Level Of Cardiac Troponin I Were Detected In Ymentioning

confidence: 81%

Alopecia Areata is Associated with Increased Expression of Heart Disease Biomarker Cardiac Troponin I

Wang

Santos²,

Li³

et al. 2018

Acta Derm Venerol

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The development of androgenetic alopecia is associated with a risk of developing cardiovascular diseases, but the association of alopecia areata with cardiovascular diseases in humans is largely unexplored. We measured the plasma level of two common cardiovascular disease markers, cardiac troponin I and C-reactive protein, in alopecia areata and androgenetic alopecia affected subjects. Also, we investigated the possible presence of pro-apoptotic factors in the plasma of hair loss subjects. The mean plasma cardiac troponin I level was highest in alopecia areata subjects, moderately higher in androgenetic alopecia subjects, and lowest in subjects without hair loss (p <0.05). Alopecia areata subjects not receiving treatments had highest levels of cTnI (p <0.05). Alopecia areata plasma samples with high cardiac troponin I levels also induced significantly higher rates of cardiomyocyte apoptosis in cell culture assays. The results suggest the potential for increased heart remodelling. Close monitoring of cardiovascular health in alopecia areata subjects, as well as subsets of androgenetic alopecia patients, may be appropriate.

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“…2a). Higher levels of cTnI were also observed in younger age groups (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) for both AA and AGA ( Fig. 2c).…”

Section: Higher Plasma Level Of Cardiac Troponin I Were Detected In Ymentioning

confidence: 81%

Alopecia Areata is Associated with Increased Expression of Heart Disease Biomarker Cardiac Troponin I

Wang

Santos²,

Li³

et al. 2018

Acta Derm Venerol

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“…While sensitivity and specificity of myoglobin for myocarditis appears to be superior to TnT-hs in the setting of myocarditis, studies that examined other forms of cardiac injury, e.g. in dilated cardiomyopathy and myocardial infarction, have identified TnT-hs to be the marker with the highest specificity and sensitivity, whereas myoglobin performed weakly [42,43]. These data suggest that myoglobin is not only a valuable qualitative, but also quantitative marker for LGE in patients with myocarditis.…”

Section: Discussionmentioning

confidence: 99%

Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Kottwitz

Bruno

Berg

et al. 2020

J. of Cardiovasc. Trans. Res.

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There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (r s = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (r s = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis.

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“…Elevated Tn is associated with increased LV diameters and volumes but not always with ejection fraction. 56,63,64 However, over 5 years of follow-up, elevated hsTnT predicted a fall in LV ejection fraction. 65 As for LGE, an independent predictor of mortality in DCM, 66 only one study has investigated its relationship with Tn, finding that hs-TnT could predict LGE extent but TnT could not.…”

Section: Dilated Cardiomyopathymentioning

confidence: 98%

“…60,65,70 The largest study describes mortality in 310 patients admitted to hospital for decompensation of heart failure due to underlying DCM; mortality over 2.2 years was significantly higher in patients with elevated TnI compared to those with normal TnI at baseline. 63 The longest follow-up study over 5.1 years describes significantly more CV events in patients with elevated TnT or hs-TnT, but not TnI.…”

Section: Prognosismentioning

confidence: 99%

Measurement of Troponin in Cardiomyopathies

2016

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Troponins are thin myofilament proteins that regulate the contraction of cardiac and skeletal muscle. The cardio-specific troponin I (TnI) and T (TnT) proteins are sensitive and specific biomarkers of myocardial injury which over the past twenty years have revolutionised the diagnosis and management of myocardial infarction. With the advent of high sensitivity assays the role for cardiac troponins is possibly expanding. Elevated levels are associated with adverse cardiovascular events and mortality in heart failure and the general population. Studies in cardiomyopathies are generally small with <200 patients, but serum troponin levels can be chronically raised and detect subclinical myocyte damage. This review examines all major published studies of cardiac troponin measurement in cardiomyopathies. There is considerable variability among studies regarding assays used and definitions of abnormal results but elevated troponin levels are almost invariably related to poor prognosis and their negative predictive value is important.

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The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy

Cited by 25 publications

References 33 publications

Alopecia Areata is Associated with Increased Expression of Heart Disease Biomarker Cardiac Troponin I

Alopecia Areata is Associated with Increased Expression of Heart Disease Biomarker Cardiac Troponin I

Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Measurement of Troponin in Cardiomyopathies

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