The prognostic value of abnormally expressed lncRNAs in colorectal cancer: A meta-analysis

Abstract

BackgroundColorectal cancer (CRC) is the third most prevalent cancer type and the third leading cause of cancer-related deaths worldwide, it is urgently needed to discover a new marker for the progress of CRC. Many long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in CRC, and may be feasible as effective biomarkers and prognostic factors. The aim of this study was to identify the prognostic value of various lncRNAs in CRC.MethodsPubmed, Web of Science, Embase and Cochrane Library were searched for potentially related studies. A total of 34 eligible studies including 30 on overall survival (OS), 7 on disease-free survival (DFS), 1 on relapse-free survival (RFS), 2 on disease-specific survival (DSS) and 29 on clinicopathological features were qualified from the databases.ResultsThe results showed that the expression levels of lncRNAs were significantly associated with poor OS (hazard ratio (HR) = 2.08, 95% confidence interval (CI) = 1.68–2.57, P<0.001, I2 = 70%), DFS (HR = 1.79, 95% CI = 1.54–2.08, P<0.001, I2 = 6%) and DSS (HR = 0.11, 95% CI = 0.02–0.54, P = 0.007, I2 = 14%). Subgroup analysis further showed that lncRNA transcription level was significantly associated with tumor differentiation (odds ratio (OR) = 0.51, 95% CI = 0.34–0.77, P = 0.001), lymph node metastasis (OR = 1.63, 95% CI = 1.23–2.17, P = 0.0007), distant metastasis (OR = 2.06, 95% CI = 1.29–3.30, P = 0.002), TNM stage (OR = 0.44, 95% CI = 0.32–0.62, P<0.001), tumor invasion depth (OR = 0.48, 95% CI = 0.39–0.60, P<0.001).ConclusionsThe meta-analysis demonstrated that abnormal lncRNA transcription level may serve as a promising indicator for prognostic of patients with CRC.

Abnormally expressed long non-coding RNAs in prognosis of Osteosarcoma: A systematic review and meta-analysis

“…Our results showed that high LncRNA expression was significantly correlated with a poorer prognosis in OS patients, which suggested that LncRNA plays an important role in the prognosis of OS. The same results were also found in the meta-analysis of other cancers such as colon cancer [47], cervical cancer [48] and prostate cancer [49]. However, there was moderate heterogeneity in multivariate analysis of overall survival (I 2 = 54%, P < 0.00001), so we performed meta-regression analysis and subgroup analysis according to race, number of patients, HR availability, cut-off values and NOS scores.…”

The Impact of lncRNA Dysregulation on Clinicopathology and Survival of Breast Cancer: A Systematic Review and Meta-analysis

“… 17 , 18 Previous reviews and meta-analyses have reported the prognostic values of lncRNAs in multiple cancers, such as colorectal cancer, ovarian cancer, prostate cancer, lung cancer, etc. 90 , 91 , 92 , 93 However, no one investigated BC specifically. Since many studies found that dysregulation of multiple lncRNAs may have an impact on the prognosis of BC, we conducted this systematic review to highlight the prognostic values of lncRNAs in BC.…”

Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review

“…miRNAs are ~ 22 nucleotides long as compared to 8–10 times longer lncRNAs. The exact functions of lncRNAs are not clear yet but it has been reported that both miRNA and lncRNAs act as regulators for controlling biological processes at post-transcriptional repression of protein-coding genes [ 101 , 102 , 105 ]. Besides,lncRNAs can also act as miRNA sponges and can reduce their regulatory effect on mRNA [ 78 ].…”

“…Some transcripts of lncRNA including Xist and Kcnq1ot1 are also involved in dosage compensation [ 24 ]. In another report, it has been mentioned that the apoptosis of breast cancer cells can be inhibited by plasmacytoma variant translocation 1 gene (PVT1) [ 101 , 102 , 105 ].…”

“…At present, there are limited reports on lncRNAs as validated biomarkers. The altered lncRNA expression pattern in uterine corpus endometrial carcinoma (UCEC) suggested that lncRNAs can act as predictive biomarkers for a high-risk patient with endometrial carcinoma [ 101 , 102 , 105 ]. Highly up-regulated in liver cancer (HULC) has been found to act as a diagnostic marker for hepatocellular cancer [ 2 ].…”