The Prognostic Value of Complete Blood Count among Patients with Acute Decompensated Heart Failure

Mene-Afejuku, Tuoyo O; Kim, Kwon Soo; Akinlonu, Adedoyin; Ngo, Emmeline M.; Salazar, Peggy; Pérez, José A.; Veranyan, Shushan; Moisa, Ela-Anamaria; Pekler, Gerald; Mushiyev, Savi; Visco, Ferdinand

doi:10.1016/j.cardfail.2019.07.422

Cited by 9 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low serum albumin concentrations may be a marker of renal and liver dysfunction or poor nutritional status. In elderly patients with heart failure, several other factors may influence serum albumin levels including ageing itself or changes in body water distribution 13 . The close relationship of both PNI components with multiple comorbid conditions may explain the higher PNI values in previous cohorts of ambulatory and clinically stable patients with heart failure compared with the PNI values found in the current study population 6,9 …”

Section: Discussionmentioning

confidence: 73%

“…Variables considered in multivariable analysis for their potential association with mortality included age, sex, levels of NT-proBNP, anaemia, and bedridden status. 12,13 NT-proBNP presented a skewed distribution and values were log-transformed before analysis. According to the World Health Organization (WHO), anaemia was defined as haemoglobin (Hb) levels <12.0 g/dL in women and <13.0 g/dL in men.…”

Section: Discussionmentioning

confidence: 99%

“…In elderly patients with heart failure, several other factors may influence serum albumin levels including ageing itself or changes in body water distribution. 13 The close relationship of both PNI components with multiple comorbid Figure 1 In-hospital, post-discharge, and overall all-cause mortality according to prognostic nutritional index. PNI, prognostic nutritional index.…”

Section: Discussionmentioning

confidence: 99%

“…In a retrospective study of 119 patients with acute decompensated heart failure, low serum albumin predicted worse survival, 13 and in a cohort of 211 elderly patients with advanced heart failure, low lymphocyte concentrations were associated with higher mortality 11 . Recently, two studies evaluated the prognostic value of the combination of serum albumin and lymphocyte count in patients with heart failure 6,9 .…”

Section: Discussionmentioning

confidence: 99%

“…The association between PNI as continuous variable and mortality was evaluated calculating hazard ratios (HRs) and the relative 95% confidence intervals (CIs) by Cox proportional regression analysis. Variables considered in multivariable analysis for their potential association with mortality included age, sex, levels of NT‐proBNP, anaemia, and bedridden status 12,13 . NT‐proBNP presented a skewed distribution and values were log‐transformed before analysis.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

Prognostic nutritional index in elderly patients hospitalized for acute heart failure

et al. 2020

View full text Add to dashboard Cite

Aims Acute heart failure (AHF) represents a frequent cause of hospitalization and is associated with significant mortality among elderly patients. Risk assessment models like the prognostic nutritional index (PNI) have been proposed to stratify the risk of death and identify patients requiring more intensive levels of care. We evaluated the predictive value of PNI for in-hospital and overall mortality in a cohort of consecutive elderly patients hospitalized for AHF. Methods and results Prognostic nutritional index, laboratory, and clinical parameters were collected upon admission. PNI values were calculated from albumin concentration and lymphocyte count and reported on a continuous scale with lower values indicating worse prognosis. The primary outcome was overall all-cause mortality defined as death from any cause occurring during hospitalization up to 6 months after discharge. Cox proportional regression analysis was used to calculate hazard ratios (HRs) and the relative 95% confidence intervals (CIs). The study population included 344 patients (median age 84 years, range 65 to 101). During a median follow-up of 158 days (range 2 to 180 days), 75 patients (21.8%) died of whom 28 (8.1%) died during hospitalization. The median PNI was 34 (range 17 to 55). In univariable analysis, PNI was inversely associated with overall mortality (HR 0.90; 95% CI, 0.87 to 0.94) and in-hospital mortality (HR 0.91; 95% CI, 0.85 to 0.98). In multivariable analysis, PNI remained a significant predictor of overall mortality (HR 0.93; 95% CI, 0.89 to 0.98) after adjustment for age, anaemia, NT-proBNP values, and bedridden status. PNI values ≤34 were associated with a twofold higher risk of overall mortality (HR 2.54; 95% CI, 1.52 to 4.24) and threefold higher risk of in-hospital mortality (HR 3.37; 95% CI, 1.14 to 9.95). Conclusions Low PNI values are associated with short-term and long-term mortality among elderly patients hospitalized for acute decompensated heart failure. Future studies are warranted to confirm these findings and evaluate the use of PNI to guide therapeutic decisions.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic nutritional index in elderly patients hospitalized for acute heart failure

et al. 2020

View full text Add to dashboard Cite

show abstract

Prognostic value of fibrosis-5 index combined with C-reactive protein in patients with acute decompensated heart failure

Wang,

Li,

Huang

et al. 2023

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Fibrosis-5 (FIB-5) index is a marker of liver fibrosis and has been shown to have a good prognostic value for patients with acute heart failure (AHF), and C-reactive protein (CRP) has inflammatory properties and predicts adverse prognosis in patients with HF. However, the long-term prognostic value of FIB-5 index combined with CRP in patients with acute decompensated HF (ADHF) is yet unclear. Methods This retrospective study included 1153 patients with ADHF hospitalized from January 2018 to May 2022.The FIB-5 index was calculated as (albumin [g/L]×0.3 + PLT count [109/L]×0.05)−(ALP [U/L]×0.014 + AST to ALT ratio×6 + 14). Patients were stratified into the following four groups according to the median value of FIB-5 index (=-2.11) and CRP (= 4.5): Group 1 had a high FIB-5 index (FIB-5 index >-2.11) and a low CRP (CRP ≤ 4.5); Group 2 had both low FIB-5 index and low CRP; Group 3 had both high FIB-5 index and high CRP; Group 4 had a low FIB-5 index (FIB-5 index ≤-2.11) and a high CRP (CRP > 4.5). The endpoint was major adverse cardiac and cerebral events (MACCEs). Multivariate Cox analysis was used to evaluate the association of the combination with the development of MACCEs. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) analysis were used to compare the accuracy of the combination with a single prognostic factor for predicting the risk of MACCEs. Results During the mean follow-up period of 584 ± 12 days, 488 (42.3%) patients had MACCEs. Kaplan–Meier analysis revealed that the incidence of MACCEs was different in the four groups (P < 0.001). After adjusting for the confounding factors, the hazard ratio (HR) for MACCEs in Group 4 (low FIB-5 index + high CRP) was the highest (Model 1, HR = 2.04, 95%CI 1.58–2.65, P < 0.001; Model 2, HR = 1.67, 95%CI 1.28–2.18, P < 0.001; Model 3, HR = 1.66, 95%CI: 1.27–2.17, P < 0.001). Additionally, the combination of FIB-5 index and CRP enabled more accurate prediction of MACCEs than FIB-5 index alone (NRI, 0.314,95%CI 0.199–0.429; P < 0.001; IDI, 0.023; 95% CI 0.015–0.032; P < 0.001). Conclusions In patients with ADHF, the combination of the FIB-5 index and CRP may be useful in risk stratification in the future.

show abstract

Assessing red blood cell distribution width in Vietnamese heart failure patients: A cross-sectional study

Dang,

Viet Luong,

Cao

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Heart failure (HF) is becoming a growing public health concern. Diagnostic tests for determining the severity of HF often come with high costs and require specialized expertise, which makes it difficult to assess HF severity, especially in low-income countries or at primary healthcare facilities. Recently, red blood cell distribution width (RDW) has emerged as a promising, easily accessible marker associated with HF severity. The study aimed to assess changes in RDW levels in HF patients and the diagnostic value of RDW in detecting acute heart failure (AHF) among HF patients. Methods We conducted a cross-sectional examination involving 351 participants divided into HF and non-HF cohorts. HF was defined and categorized according to the diagnostic and treatment guidelines for AHF and chronic heart failure (CHF) set forth by the European Society of Cardiology (2021). Univariate and multivariate analysis of factors associated with AHF was performed. Results The study revealed that HF patients displayed higher median RDW levels (14.90% [13.70–17.00]) compared to non-HF individuals (13.00% [12.23–13.78]). RDW was notably elevated in HF patients with left ventricular ejection fraction < 50% compared to those with left ventricular ejection fraction ≥ 50%. ROC curve analysis of RDW for AHF detection identified a cutoff value of 13.85%, with a sensitivity of 86.05% and specificity of 47.18%, statistically significant at p < 0.001. RDW > 13.85% was identified as an independent risk factor for AHF in patients with HF, with odds ratios of 2.644 (95% CI, 1.190–5.875; p = 0.017). Conclusion The study revealed significant RDW variations in patients with CHF and AHF compared to the control group. These findings suggest that RDW could be a biomarker for detecting HF severity.

show abstract

The Prognostic Value of Complete Blood Count among Patients with Acute Decompensated Heart Failure

Cited by 9 publications

References 0 publications

Prognostic nutritional index in elderly patients hospitalized for acute heart failure

Prognostic nutritional index in elderly patients hospitalized for acute heart failure

Prognostic value of fibrosis-5 index combined with C-reactive protein in patients with acute decompensated heart failure

Assessing red blood cell distribution width in Vietnamese heart failure patients: A cross-sectional study

Contact Info

Product

Resources

About