The prognostic value of elevated ezrin in patients with osteosarcoma

Abstract

Published studies researching the prognostic significance of ezrin expression in patients with osteosarcoma are inconclusive and heterogeneous. We conducted a meta-analysis to assess its prognostic value more precisely. The hazard ratios with corresponding 95 % confidence intervals were calculated to evaluate the effects. Five studies with 318 osteosarcoma patients were included to estimate the relationship between ezrin and disease-free survival, and ezrin and overall survival. Compared with osteosarcoma patients with low or negative ezrin expression, patients with high ezrin expression tended to be associated with lower disease-free survival, but the difference was not significant. However, patients with high ezrin expression were obviously associated with lower overall survival. Therefore, the findings from this systematic review suggest that ezrin expression is an effective biomarker of prognosis in patients with osteosarcoma.

Prognostic implications ofRB1tumour suppressor gene alterations in the clinical outcome of human osteosarcoma: a meta-analysis

“…Interestingly, alterations in a few other candidate genes, such as p53 (Fu et al 2013), ezrin (Lun et al 2014) and vascular endothelial growth factor (Qu et al 2012), have also been proposed as potential prognostic makers for osteosarcoma other than the RB1 gene we reported here. Interestingly, alterations in a few other candidate genes, such as p53 (Fu et al 2013), ezrin (Lun et al 2014) and vascular endothelial growth factor (Qu et al 2012), have also been proposed as potential prognostic makers for osteosarcoma other than the RB1 gene we reported here.…”

“…Substantial efforts have been made to search for novel molecular markers to guide the management and improve the prognosis of osteosarcoma patients in recent years. Interestingly, alterations in a few other candidate genes, such as p53 (Fu et al 2013), ezrin (Lun et al 2014) and vascular endothelial growth factor (Qu et al 2012), have also been proposed as potential prognostic makers for osteosarcoma other than the RB1 gene we reported here. It is worth noting that the prognostic values of these candidate genes have been investigated individually in the majority of studies.…”

The clinical significance of changes in ezrin expression in osteosarcoma of children and young adults

“…Similar results were presented by Xu-Dong et al [26], who revealed that the high mRNA level of ezrin gene was related to shorter lungmetastasis-free and overall survival time of patients with osteosarcoma. Lastly, two independent meta-analyses by Wang et al [32] and Lun et al [33], both including five studies of 318 patients with osteosarcoma, showed that overall survival was significantly lower in patients with osteosarcoma with high ezrin expression at biopsy.…”

Effects of Ezrin and Heat Shock Protein 70 on Apoptosis and Proliferation of Human Osteosarcoma Cells

“…Rho or Akt signaling pathways regulate the phosphorylation of ezrin to inhibit apoptosis and promote cellular proliferation. Meta‐analysis has shown that ezrin expression is significantly upregulated in osteosarcoma tissues and correlates negatively with five‐year survival rate. However, the role of ezrin in osteosarcoma has not been studied.…”