2006
DOI: 10.1111/j.1525-1438.2006.00658.x
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The prognostic value of endoglin (CD105) expression in ovarian carcinoma

Abstract: Intratumoral angiogenesis has become an important issue after the identification of antiangiogenic therapeutics. The purpose of this study was to investigate the prognostic value of CD105 in patients with ovarian cancer and also to compare with CD31. Fifty-eight patients were included to this study. All the paraffin blocks were reviewed, and angiogenesis was determined by immunohistochemical staining, using anti-CD105 and anti-CD31 monoclonal antibodies. The mean microvessel density (MVD) with CD105 and CD31 w… Show more

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Cited by 52 publications
(47 citation statements)
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“…Immunohistochemical analyses have shown increased endoglin expression in a variety of malignancies such as esophagus (35), lung (36), breast (37,38), ovary (39), endometrium (39), and prostate cancer (11). In addition, endoglin expression has been shown to be an independent predictor of outcome in endometrial and ovarian cancers (39,40). Plasma endoglin levels have been observed to be higher in patients who had metastases (10), suggesting elevated plasma endoglin levels could be a surrogate marker for tumor angiogenesis and, thereby, help identify early metastases during follow-up (9,10).…”
Section: Discussionmentioning
confidence: 99%
“…Immunohistochemical analyses have shown increased endoglin expression in a variety of malignancies such as esophagus (35), lung (36), breast (37,38), ovary (39), endometrium (39), and prostate cancer (11). In addition, endoglin expression has been shown to be an independent predictor of outcome in endometrial and ovarian cancers (39,40). Plasma endoglin levels have been observed to be higher in patients who had metastases (10), suggesting elevated plasma endoglin levels could be a surrogate marker for tumor angiogenesis and, thereby, help identify early metastases during follow-up (9,10).…”
Section: Discussionmentioning
confidence: 99%
“…CSCs of various origins have been reported to express different marker proteins like ABCG2, ALDH1, CD44, CD24 and CD133, Thy-1, Sca-1 [45][46][47][48][49][50][51][52][53][54]. Such marker proteins, hence, have a great potential to be harnessed as biomarkers for CSCs.…”
Section: Biomarkers Of Cancer Stem Cells and The Respective Roles Of mentioning
confidence: 99%
“…However, CD105 was exclusively expressed on actively proliferating ECs of newly formed BVs but not on the normal pre-existing ones while CD31 was found to stain all BVs indiscriminately whether newly formed small or native large ones. Such finding is related to the selective staining of CD105 to actively proliferating ECs (Nagatsuka et al, 2005) on the contrary to CD31 which is not selective for epitopes on ECs but also aimed at those on inflammatory, mesechymal, neoplastic and non-neoplastic epithelial cells leading to their confused with microvessels (Taskiran et al, 2006). …”
mentioning
confidence: 99%
“…However, the accuracy of MVD assessment with these pan-endothelial markers may not be the highest possible since they cannot distinguish newly formed tumoral blood vessels (BVs) from normal pre-existed BVs which in turn rises the need for a marker that is strictly specific for tumor-induced angiogenesis (Martone et al, 2005 andTaskiran et al, 2006). CD105 is a transforming growth factor beta (TGF-β) binding receptor preferentially expressed on endothelial cells (ECs) of all angiogenic tissues, including tumors, but weakly or not at all with those of normal tissues (Marioni et al, 2006) giving it the superiority as a marker with a greater specificity for tumor-induced angiogenesis.…”
mentioning
confidence: 99%
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