The prognostic value of fibrinogen to albumin ratio in malignant tumor patients: A meta-analysis

Li, Baibei; Deng, Huachu; Lei, Biao; Chen, Leijie; Zhang, Mengjie; Sha, Dingran

doi:10.3389/fonc.2022.985377

Cited by 18 publications

(11 citation statements)

References 65 publications

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“…There is a pressing need for more comprehensive studies on how Fg levels may interfere with various chemotherapy regimens and impact the development of therapy resistance. Furthermore, future investigations could delve into the prognostic significance of plasma Fg ratios when combined with other tumor prognostic markers, such as the fibrinogen-to-albumin ratio ( 137 , 138 ), F-NLR (fibrinogen and neutrophil-lymphocyte ratio) ( 139 ), among others. Additionally, there is scope for further exploration of the roles played by Fg fragments, including FGA, FGB, and FGG, in the context of tumor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen and tumors

Wu,

Yu,

Chen

et al. 2024

Front. Oncol.

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Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentuating its role as a regulator of inflammatory processes. Specifically, Fg serves to stimulate and recruit immune cells and pro-inflammatory cytokines, thereby contributing to the promotion of tumor progression. Additionally, Fg and its fragments exhibit dichotomous effects on tumor angiogenesis. Notably, Fg also facilitates tumor migration through both platelet-dependent and platelet-independent mechanisms. Recent studies have illuminated several tumor-related signaling pathways influenced by Fg. This review provides a comprehensive summary of the intricate involvement of Fg in tumor biology, elucidating its multifaceted role and the underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Fibrinogen and tumors

Wu,

Yu,

Chen

et al. 2024

Front. Oncol.

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“…Numbers studies have confirmed that the FAR is an important marker that reflects systemic inflammatory diseases. Some studies have shown that the FAR can be used as a prognostic indicator for coronary artery severity, stroke, cerebral haemorrhage, tumours (such as pancreatic cancer and liver cancer), COVID-19 and other diseases ( Li et al, 2022 ; Rathore et al, 2022 ; Lin et al, 2022 ). As a predictor of diabetic complications like Kidney disease and arteriosclerosis, the FAR was more effective than any single indicator ( Wang et al, 2021 , 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Liver-produced fibrinogen and albumin are useful biomarkers for inflammation and haemodynamic changes ( Chapin & Hajjar, 2015 ; Luyendyk, Schoenecker & Flick, 2019 ; Deveci & Gazi, 2021 ). Fibrinogen/albumin ratio (FAR) was more effective in predicting inflammation and tumors combined the two indicators ( Omiya et al, 2021 ; Li et al, 2022 ). Moreover, FAR is a stronger independent predictor of diabetic kidney disease than FIB and ALB ( Wang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios

Li,

Wu,

Kong

et al. 2023

PeerJ

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Background Cognitive impairment is the main manifestation of diabetes central neuropathy. Currently, there is no effective dementia treatment; early diagnosis and treatment are particularly crucial. Inflammation index fibrinogen-to-albumin ratio (FAR) has been shown to predict complications of type 2 diabetes (diabetic kidney disease and diabetes-related arteriosclerosis), but its relationship with mild cognitive impairment (MCI) in type 2 diabetes (T2D) is undetermined. In this study, we examined the association between the FAR and mild cognitive impairment in type 2 diabetes. Methods This is a retrospective and cross-sectional study. From January 2022 to December 2022, we have retrieved 328 inpatient medical records for T2D patients hospitalized at the First Hospital of Harbin Medical University from the hospital’s electronic system. Subjects’ cognitive function was assessed and grouped by the MoCA scales. Subjects’ demographic and various laboratory indicators were collected. Using Spearman’s bivariate correlation analysis, the FAR and other clinical variables were analyzed for association strength. A multiple linear regression analysis was conducted to determine the independent relationship between FAR and MoCA scores. Multivariate logistic regression was used to analyze the independent relationship between FAR and MCI. The capacity of the FAR to detect MCI was carried using receiver operating characteristic (ROC) analysis. Results The included participants’ (n = 328; 61.9% male) mean age was 52.62 ± 10.92 years. MoCA scores and MCI prevalence significantly differed (p < 0.05) between the four subgroups of FAR quartiles. The FAR and the MoCA score were significantly negatively correlated in the entire population (p < 0.05). Based on the multiple linear regression analysis, lnFAR and lnMoCA are significantly correlated (β = −0.449, t = −8.21, p < 0.05, R2 = 0.469). In multivariate logistic regression analysis, FAR and MCI were independently correlated after adjusting for covariates (OR 95% CI 34.70 [13.90–86.66]). Finally, the analysis of receptor working characteristics shows that the optimal FAR cut-off value was 0.08 (sensitivity: 95.81%, specificity: 84.47%) for detecting MCI in type 2 diabetes. Conclusion In type 2 diabetes, the FAR was positive associations with MCI and negative associations with MoCA score. The high FAR was associated with an increased risk of MCI. FAR maybe a appropriate indicator of MCI risk for type 2 diabetes.

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“…Fibrinogen is produced by the liver as an indicator of the procoagulant state, which plays a role in inflammatory reactions at various levels [ 6 ]. Albumin is the most abundant plasma protein and an essential protein in human plasma.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of the fibrinogen-to-albumin ratio (FAR) in patients with chronic heart failure across the different ejection fraction spectrum

Yang,

Pi,

et al. 2024

Libyan Journal of Medicine

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The ratio of fibrinogen to albumin (FAR) is considered a new inflammatory biomarker and a predictor of cardiovascular disease risk. However, its prognostic value for patients with chronic heart failure (CHF) with different ejection fractions (EFs) remains unclear. A total of 916 hospitalized patients with CHF from January 2017 to October 2021 in the First Affiliated Hospital of Kunming Medical University were included in the study. Death occurred in 417 (45.5%) patients out of 916 patients during a median follow-up time of 750 days. Among these patients, 381 patients suffered from HFrEF (LVEF <40%) and 535 patients suffered from HFpEF or HFmrEF (HFpEF plus HFmrEF, LVEF ≥ 40%). Patients were categorized into high-level FAR (FAR-H) and low-level FAR (FAR-L) groups based on the optimal cut-off value of FAR (9.06) obtained from receiver operating characteristic (ROC) curve analysis. Upon analysing the Kaplan – Meier plots, the incidence of death was significantly higher in all patients with FAR-H and patients in both HF subgroups ( p < 0.001). The multivariate Cox proportional hazard analyses indicated that the FAR was an independent predictor of all-cause mortality, regardless of heart failure subtype. (HR 1.115, 95% CI 1.089–1.142, p < 0.001; HFpEF plus HFmrEF, HR 1.109, 95% CI 1.074–1.146, p < 0.0001; HFrEF, HR 1.138, 95% CI 1.094–1.183, p < 0.0001) The optimal cut-off value of FAR in predicting all-cause mortality was 9.06 with an area under the curve value of 0.720 (95% CI: 0.687–0.753, p < 0.001), a sensitivity of 68.8% and a specificity of 65.6%. After adjusting for the traditional indicators (LVEF, Lg BNP, etc.), the new model with the FAR had better prediction ability in patients with CHF. Elevated FAR is an independent predictor of death in CHF and is not related to the HF subtype.

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The prognostic value of fibrinogen to albumin ratio in malignant tumor patients: A meta-analysis

Cited by 18 publications

References 65 publications

Fibrinogen and tumors

Fibrinogen and tumors

Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios

Prognostic value of the fibrinogen-to-albumin ratio (FAR) in patients with chronic heart failure across the different ejection fraction spectrum

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