The prognostic value of glycerol‐3‐phosphate dehydrogenase 1‐like expression in head and neck squamous cell carcinoma

Feng, Zhien; Li, Jian Nan; Wang, Lin; Pu, Yin Fei; Wang, Yixiang; Guo, Chuan Bin

doi:10.1111/his.12258

Cited by 19 publications

(21 citation statements)

References 12 publications

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“…In the future, the identification of crucial gene signatures will represent a greater advantage in personalized medicine compared with traditional clinicopathological factors 27 . Based on results from our recent studies, several potential biomarkers, such as cyclin D1, enhancer of zeste homologue 2 and glycerol-3-phosphate dehydrogenase 1-like gene, can assist in guiding adjuvant therapy decisions and stratifying high-risk prognostic populations and might have a more accurate efficiency than clinical the TNM stage 18 , 25 , 28 , 29 . The concept of precision medicine based on translational research and novel pathological features is the most promising breakthrough that will further improve the quality of life and long-term survival of patients with head and neck cancer.…”

Section: Discussionmentioning

confidence: 99%

Lymph node ratio is associated with adverse clinicopathological features and is a crucial nodal parameter for oral and oropharyngeal cancer

Feng

Wang

et al. 2017

Sci Rep

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The lymph node ratio(LNR) has been described as a novel predictor of the survival of patients with oral and oropharyngeal squamous cell carcinoma(O/OPSCC). The purpose of this study was to evaluate whether LNR is better at predicting survival and the need for adjuvant treatment than traditional tumour-nodal-metastasis(TNM) staging. Eight hundred nine patients with O/OPSCC and positive lymph node disease were retrospectively enrolled in this study. LNR equal to 0.075 is the best cut-off value for stratifying 5-year disease-free survival(DFS). High LNR is closely associated with more advanced T stage, higher N stage, more severe pathological grade, the presence of diffuse infiltration and extracapsular spread(ECS). LNR is better for evaluating prognosis than the pathological N stage. Patients with high LNR coupled with high number of positive lymph nodes who received adjuvant concurrent chemo-radiotherapy(CCRT) had a better 5-year DFS than patients who received surgery alone. Multivariate analyses revealed that T stage, ECS and LNR are independent prognostic factors of 5-year DFS and disease-specific survival(DSS). Therefore, high LNR is closely correlated with adverse parameters that markedly hinder prognosis. LNR is superior to traditional TNM staging for the evaluation of prognosis,and the combination of the LNR with the number of positive lymph nodes can predict the benefits of adjuvant CCRT.

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Section: Discussionmentioning

confidence: 99%

Lymph node ratio is associated with adverse clinicopathological features and is a crucial nodal parameter for oral and oropharyngeal cancer

Feng

Wang

et al. 2017

Sci Rep

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“…GPD1L has the glycerol-3-phosphate dehydrogenase enzyme activity and is a regulator of HIF-1α stability [40]. And a recent study showed that the GPD1L expression is a strong predictor for local recurrence and survival in HNSCC [39]. HLF belongs to the PAR (proline and acidic amino acid-rich) subfamily of bZIP transcription factors [43, 44], and plays a role in development and circadian rhythm regulation in the mammalian.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma

Chen

Dong

et al. 2016

BMC Cancer

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BackgroundOral tongue squamous cell carcinoma (OTSCC) is one of the most aggressive forms of head and neck/oral cancer (HNOC), and is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. Identifying the deregulation of microRNA-mRNA regulatory modules (MRMs) is crucial for understanding the role of microRNA in OTSCC.MethodsA comprehensive bioinformatics analysis was performed to identify MRMs in HNOC by examining the correlation among differentially expressed microRNA and mRNA profiling datasets and integrating with 12 different sequence-based microRNA target prediction algorithms. Confirmation experiments were performed to further assess the correlation among MRMs using OTSCC patient samples and HNOC cell lines. Functional analyses were performed to validate one of the identified MRMs: miR-21-15-Hydroxyprostaglandin Dehydrogenase (HPGD) regulatory module.ResultsOur bioinformatics analysis revealed 53 MRMs that are deregulated in HNOC. Four high confidence MRMs were further defined by confirmation experiments using OTSCC patient samples and HNOC cell lines, including miR-21-HPGD regulatory module. HPGD is a known anti-tumorigenic effecter, and it regulates the tumorigenic actions of Prostaglandin E2 (PGE2) by converts PGE2 to its biologically inactive metabolite. Ectopic transfection of miR-21 reduced the expression of HPGD in OTSCC cell lines, and the direct targeting of the miR-21 to the HPGD mRNA was confirmed using a luciferase reporter gene assay. The PGE2-mediated upregulation of miR-21 was also confirmed which suggested the existence of a positive feed-forward loop that involves miR-21, HPGD and PGE2 in OTSCC cells that contribute to tumorigenesis.ConclusionsWe identified a number of high-confidence MRMs in OTSCC, including miR-21-HPGD regulatory module, which may play an important role in the miR-21-HPGD-PGE2 feed-forward loop that contributes to tumorigenesis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2716-0) contains supplementary material, which is available to authorized users.

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“…Therefore, expression of a large number of metastasis-related genes in the PT has been found to correlate with cancer patient overall survival. However, metastatic foci may be more crucial for predicting the prognosis of patients with LNM, particularly OSCC patients with an ~45% chance of suffering metastasis to the neck lymph nodes (5). OSCC tends to metastasize to the cervical lymph nodes (19).…”

Section: Discussionmentioning

confidence: 99%

“…This is mainly due to the high metastatic rates to cervical lymph nodes (2,3), particularly in oral squamous cell carcinoma (OSCC), which accounts for more than 90% of all oral cancer cases (4). In addition, nearly 45% of OSCC patients present with lymph node metastasis (LNM) (5) and their overall survival decreases to 28% (6).…”

Section: Introductionmentioning

confidence: 99%

High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis

Wang

et al. 2014

Oncology Reports

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The aim of the present study was to examine the clinical significance of lymph node metastatic (LNM) foci in predicting the overall survival of oral squamous cell carcinoma (OSCC) patients with LNM. MMP-21 was screened based on the LNM animal model of OSCC. Then four proteins, matrix metalloproteinase (MMP)-2, MMP-21, vascular endothelial growth factor (VEGF)-C and VEGF receptor (VEGFR)-3 were examined by immunohistochemistry in 63 OSCC specimens, including the primary tumors (PTs) and the corresponding LNM foci. The expression levels between the PTs and LNM foci were compared by Wilcoxon paired test. Relationships between expression of the four proteins and patient overall survival were assessed by Kaplan-Meier based on the median of the labeling index. The Cox proportional hazards model was used to assess the relative hazard factors. MMP-21 and VEGF-C expression levels were higher in the LNM foci than levels in the PTs. Results showed that MMP-2 and VEGF-C expression levels in the PTs and MMP-2, MMP-21 and VEGF-C expression in the LNM foci correlated with the overall survival of the OSCC patients with lymphatic metastasis. MMP-21 expression level in the LNM foci was the most reliable predictor among all the tested factors. These results suggest that high MMP-21 expression in LNM foci can be used to predict survival in OSCC patients with LNM. Characteristics of LNM foci may be more reliable than PT characteristics in predicting the overall survival of OSCC patients with lymphatic metastasis.

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The prognostic value of glycerol‐3‐phosphate dehydrogenase 1‐like expression in head and neck squamous cell carcinoma

Abstract: Our results indicate that the GPD1L expression is a strong predictor for local recurrence and survival in HNSCC.

Cited by 19 publications

References 12 publications

Lymph node ratio is associated with adverse clinicopathological features and is a crucial nodal parameter for oral and oropharyngeal cancer

Lymph node ratio is associated with adverse clinicopathological features and is a crucial nodal parameter for oral and oropharyngeal cancer

MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma

High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis

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