The Prognostic Value of Human Papilloma Virus Infection in Oral Cavity Squamous Cell Carcinoma: A Meta‐Analysis

Abstract

Objectives/Hypothesis: Human papilloma virus (HPV) infection has been confirmed as a favorable prognostic factor in oropharyngeal cancer. However, the prognostic value of HPV in oral squamous cell carcinoma (OSCC) is still unclear. Therefore, a systematic review and meta-analysis was performed to evaluate the prognostic value of HPV infection in OSCC patients.Study Design: Systematic literature review with meta-analysis.Methods: A systematic literature review was conducted in accordance with PRISMA guidelines in PubMed, EMBASE, and MEDLINE databases. The primary outcomes were overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and secondary outcomes were local control (LC), regional control (RC), and distant control (DC).Results: A total of 22 articles with 3065 OSCC patients were included in this study. Meta-analysis demonstrated that compared to HPV-negative OSCC patients, HPV-positive OSCC patients had a significantly shorter OS (hazard ratio [HR]

Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

“…Limitations of this study are that 1 – the work was conducted in a retrospective fashion; 2 - all cases were from a single institution; 3 – TMAs allow for only a limited area of tumor (and stroma) components for evaluation; 4 – TMA consisted of a relatively small sample size; and 5 – lack of HPV+ OSCCs in the patient cohort. Although HPV OSCCs are rare, there is evidence of HPV’s role in predicting patient prognosis ( 71 ) and there may be a benefit to including HPV+ cases in our future studies. Lastly, it is acknowledged that the expression of inhibitory checkpoints including programmed cell death-ligand 1 (PD-L1) and programmed cell death-protein 1 (PD1) regulate T-cell response ( 72 , 73 ).…”

Emerging histological and serological biomarkers in oral squamous cell carcinoma: Applications in diagnosis, prognosis evaluation and personalized therapeutics (Review)

“…On the other hand, the prognostic utility of p16 in OSCC differs among studies given its low prevalence, although according to studies such as that by Doll et al ( 34 ), P16 expression is connected to a better survival rate in individuals undergoing primary surgery with adjuvant radio(chemo)therapy ( 34 ). However, meta-analyses such as that of Christianto et al ( 35 ), which evaluated 22 articles comprising 3,065 patients with OSCC, observed that HPV-positive OSCC is associated with significantly decreased survival.…”

Oral Bacteria, Virus and Fungi in Saliva and Tissue Samples from Adult Subjects with Oral Squamous Cell Carcinoma: An Umbrella Review

“…Of the 32 studies included , 20 were systematic reviews with meta-analysis [36][37][38]41,44,46,49,50,53,54,56,57,[59][60][61][62][63][64][65][66] and 12 without meta-analysis [35,39,40,42,43,45,47,48,51,52,55,58]. The 32 systematic reviews included 642 studies that met the eligibility criteria of this umbrella review, in particular, 248 case-control studies, 29 cohort studies, 20 cross-sectional studies, 10 non-randomized studies, 2 retrospective cross-sectional studies, 1 cross-sectional cohort study, 1 prospective study, and 331 articles where the study design had not been defined.…”

“…Twenty-two studies [37][38][39][40][41]44,46,47,[49][50][51]53,54,56,57,[59][60][61][63][64][65][66] described the oral viral content in adult subjects with OSCC, in particular, two studies [47,54] of the OSCCtissue samples and saliva, twenty studies [37][38][39][40][41]44,46,[49][50][51]56,57,[59][60][61]63,65,66] only in the OSCC-tissue samples, and two studies [53,64] only of the saliva.…”