The prognostic value of long non coding RNAs in non small cell lung cancer: A meta-analysis

Abstract

Background Reports have demonstrated the prognostic function of long non-coding RNAS (lncRNAS) in patients with cancer. However, their prognostic functions in non small cell lung cancer (NSCLC) remain controversial. We therefore performed a meta-analysis on six lncRNAs (PVT1, AFAP1-AS1, LINC01133, ANRIL, MEG3 and UCA1) to clarify their prognostic roles in NSCLC. Results Thirty-six studies involving 6267 patients with NSCLC and 34 lncRNAs were included. Of the listed lncRNAs, 20 were shown to negatively affect patients' overall survival while the high expression of 13 lncRNAs indicated better survival outcomes. Materials and Methods The log-rank p value and Kaplan–Meier survival curves of survival outcomes were extracted for hazard ratio (HR) calculation. Survival outcomes were measured by overall survival (OS) and event free survival (EFS) which were then analyzed by calculating pooled hazard ratios. The heterogeneity was detected by Q statistic and I-squared statistic. Conclusions The abnormal expression of lncRNAs may significantly affect NSCLC patients' survival and may serve as a novel predictive factor for prognosis of NSCLC patients.

lncRNA HNF1A‐AS1 modulates non–small cell lung cancer progression by targeting miR‐149‐5p/Cdk6

“…Although numerous molecular markers have been identified for the diagnosis and prognosis of cancer, only a few effective molecular markers can predict the recurrence of NSCLC. Induced lncRNA PVT1 occurred in NSCLC tissues and had a shorter OS time than patients with low PVT1 expression .…”

Long non‐coding RNA linc01433 promotes migration and invasion in non‐small cell lung cancer

“…To improve treatment of patients with NSCLC, novel tumor‐specific biomarkers are needed for diagnosis, targeted therapy, and to predict prognosis LncRNAs are associated with pathological and physiological processes in numerous human cancers. The dysregulated expression of certain lncRNAs has been proven to be associated to proliferation and metastasis in NSCLC . Linc01433 is located on chromosome 20p13 in humans and has a length of 682 bp.…”

“…Col‐1, a potent inducer of EMT, regulates the expression of HOTAIR in NSCLC cells, whereas HOTAIR interacts with a chromatin modifier, lymphoid‐specific helicase (LSH), to target genes in NSCLC . Although substantial research of lung‐cancer‐related lncRNAs has been conducted, no lncRNA that can serve as a single molecular marker to diagnose lung cancer has been identified, therefore we need to explore other lncRNAs to obtain a better understanding of this disease. In our previous study, we focused on one of the genes with a change in expression between tumor tissues and matched normal lung tissues, determined by RNA‐sequencing .…”

The prognostic significance of long noncoding RNAs in bladder cancer: A meta-analysis

“…More importantly, aberrant expression of multiple lncRNAs were found to be involved in the tumorigenesis and many of them were correlated with cancer prognosis [ 9 – 11 ]. Multiple lncRNAs have been reported to be promising prognostic indicators for cancers, such as hepatocellular carcinoma [ 12 ], non small cell lung cancer [ 13 , 14 ], osteosarcoma [ 15 ], ovarian carcinoma [ 16 ], and renal cell carcinoma [ 17 ]. So far, many studies have shown that lncRNAs also played critical roles in BC [ 18 ], these findings support that lncRNAs can be developed as novel potential prognostic biomarkers in patients with BC.…”