The prognostic value of neutrophil-to-lymphocyte ratio in de novo stage IV breast cancer: a retrospective cohort study

Shao, Bin; Li, Huiping; Liu, Xiaoran; Song, Guohong; Jiang, Hanfang; Yan, Ying; Zhang, Ruyan; Ran, Ran; Zhang, Jiayang; Liu, Yaxin; Wang, Huan; Wang, Jing; Di, Lijun

doi:10.21037/atm-22-5612

Cited by 3 publications

(1 citation statement)

References 42 publications

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“… 11 Secondly, for decades, serum albumin has been used as an indicator of clinical nutritional status. 12 Thirdly, lymphocyte count is a traditional biomarker for immune function. 13 Finally, we found that the CRP-albumin-lymphocyte (CALLY) index (a parameter developed by Hiroya Iida et al) combines CRP, albumin, and lymphocytes, and is a prognostic factor for liver cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of CRP–Albumin–Lymphocyte (CALLY) Index in Patients Undergoing Surgery for Breast Cancer

Zhuang,

Wang,

Wang

et al. 2024

IJGM

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Purpose According to the 2023 global cancer data, breast cancer is the most common malignant tumor among women in the world. Its occurrence and development is influenced by inflammation, nutrition, and immune status. Therefore, this study combines C-reactive protein (CRP), albumin, and lymphocyte, which can reflect the above states, to form the CRP-albumin-lymphocyte (CALLY) index, an indicator to evaluate its relationship with overall survival (OS) and disease-free survival (DFS) in breast cancer patients. Patients and Methods We retrospectively analyzed the clinical and follow-up data of 174 patients with breast cancer. The optimal cutoff for the preoperative CALLY index was identified by considering the area under the receiver operating characteristic curve; subsequently, the discriminatory ability of the cutoff was determined. The effect of the CALLY index on overall survival (OS) and disease-free survival (DFS) was analyzed using the Kaplan–Meier method and the Cox proportional hazards model. The CALLY index was calculated as: (Albumin × Lymphocyte)/(CRP × 10 4 ). Results The cut-off value of the CALLY index was determined at 2.285. With a cut-off value of 2.285, patients were divided into two groups: those with CALLY <2.285 and those with CALLY ≥2.285. CALLY Index ≥ 2.285 was associated with better survival outcomes. Multivariate Cox analysis showed that TNM stage and CALLY index were prognostic factors that affected OS and DFS. Conclusion The CALLY index is a new prognostic biomarker for breast cancer patients after surgery. This new CALLY index allows for suitable patients with a poor prognosis to receive postoperative adjuvant therapy.

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Section: Introductionmentioning

confidence: 99%