The prognostic value of p53 expression in negative surgical margins of early glottic carcinoma in the prediction of local recurrences

Öztürk, Kerem; Göde, Sercan; Gürsan, Gülce; Veral, Alı; Akyıldız, Serdar

doi:10.3109/00016489.2013.871747

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…27 Ozturk et al proposed that, in the surgical treatment of early glottic carcinoma, overexpression of P53 was more valuable for predicting recurrence and prognosis in the incisional margin tissue than in the primary tumor tissue. 28 P27 is a member of the cyclin-dependent kinase inhibitors family, which plays a negative regulatory role in the cell cycle, preventing the cell cycle from entering the S phase, thereby inhibiting cell proliferation. 29 After detecting the expression of P27 protein in laryngeal squamous cell carcinoma, researchers concluded that the inactivation of P27 in resection margin tissues was closely related to local recurrence of laryngeal cancer.…”

Section: Tumor Suppressor Genesmentioning

confidence: 99%

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Research Progress Regarding Surgical Margins, Molecular Margins, and Prognosis of Laryngeal Carcinoma

Ye¹,

Yang

Yao

et al. 2020

Ear Nose Throat J

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Background: Laryngeal carcinoma is one of the most common malignant tumors of the head and neck. Researchers have refined the study of surgical margin in the anatomical subarea of the larynx to determine the most appropriate distance of the surgical margin for laryngeal carcinoma, to achieve accurate resection of laryngeal carcinoma and to improve the possibility of retention of laryngeal function. Methods: A comprehensive review of the primary literature was performed from 2009 to 2019 utilizing keywords laryngeal carcinoma, surgical margin, molecular margin, and prognostic factor. Articles were included at the discretion of the authors based on novel and/or contributions to the literature. Results: The prognosis of laryngeal carcinoma significantly correlates with the status of surgical margins. Patients with positive surgical margins have higher recurrence and metastasis rates and worse prognosis. Patients with negative pathological surgical margin but with the expression or altered expression levels of one or more tumor-related molecular biomarkers had high rates of recurrence and metastasis, and poor prognosis. Conclusions: Clinical intervention can improve the prognosis of patients with positive surgical margins. Patients with close margins should be followed closely. Among patients with negative surgical margins, patients with abnormal molecular margin results should be closely followed up. However, the specific selection of one or several molecular biomarkers as the detection index of molecular margin currently requires multicenter prospective or retrospective large sample study as guidance.

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Section: Tumor Suppressor Genesmentioning

confidence: 99%

Section: Relationship Between Common Molecular Biomarkers and Prognosismentioning

confidence: 99%

Research Progress Regarding Surgical Margins, Molecular Margins, and Prognosis of Laryngeal Carcinoma

Ye¹,

Yang

Yao

et al. 2020

Ear Nose Throat J

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show abstract

“…The results of the immunohistochemical staining were evaluated by an anatomo-pathologist doctor. As described in previous studies, 5% of the cutoff for survivin and p53 expression, 15,16 1% for p16 expression 17 and 6% for IGF-1R expression 18 were considered. The survivin and p53 immunostaining was scored as follows: score 0: <5%; score 1: 5% to 25%; score 2: 26% to 50%; score 3: >50%.…”

Section: Evaluation Of Immunostainingmentioning

confidence: 99%

Prevalence and Prognostic Value of HPV among Tunisian Patients with Laryngeal Cancer and Relationship between DNA HPV and p16, IGF-1R, Survivin, p53 Expressions

Elhadj

Fourati

Amine

et al. 2020

Ann Otol Rhinol Laryngol

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Objectives: Tobacco and alcohol are the main etiological factors common to laryngeal cancers. However, the Human Papilloma Virus (HPV) constitutes an alternative risk factor according to several studies. In Tunisia, despite the annual increasing incidence of laryngeal squamous cell carcinoma (LSCC), the prevalence and prognostic significance of HPV have never been explored. In this study, we sought to highlight HPV DNA in 70 biopsies of laryngeal cancer, and to analyze the status of HPV infection in association with p53, p16, survivin, and IGF-1R expressions. Methods: HPV high risk (HPV HR) DNA was detected in tumors by in situ hybridization. However, the expression of p53, p16, survivin and IGF-1R were stained by immunohistochemistry test. The correlations of HPV status with clinicopathological parameters, overall survival, disease-free survival and proteins expressions were statistically evaluated. Results: HPV HR DNA was detected in 39 out of 70 (55.71%) laryngeal tumors. HPV+ patients have a better overall survival ( P = .081) and long disease-free-survival ( P = .016) with a low rate of recurrence ( P = .006) than HPV– patients. No significant correlations were found between HPV HR status and clinicopathological parameters (all P > .005). Moreover, HPV+ tumors were not associated with expression of p53, p16 and survivin. However, HPV HR status correlates with weak to moderate IGF-1R expression ( P = .043). Conclusion: The substantial detection of HPV HR in LSCC tumors suggest that this virus plays an important part in laryngeal cancer in Tunisia. It is a good prognostic factor. In addition, HPV infection could act to block the pathway of IGF-1R expression.

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Risk factors for local recurrence of early bilateral vocal cord carcinoma treated with transoral CO₂ laser microsurgery

Tan

Fang

Wang

et al. 2021

Acta Oto-Laryngologica

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The prognostic value of p53 expression in negative surgical margins of early glottic carcinoma in the prediction of local recurrences

Cited by 4 publications

References 15 publications

Research Progress Regarding Surgical Margins, Molecular Margins, and Prognosis of Laryngeal Carcinoma

Research Progress Regarding Surgical Margins, Molecular Margins, and Prognosis of Laryngeal Carcinoma

Prevalence and Prognostic Value of HPV among Tunisian Patients with Laryngeal Cancer and Relationship between DNA HPV and p16, IGF-1R, Survivin, p53 Expressions

Risk factors for local recurrence of early bilateral vocal cord carcinoma treated with transoral CO₂ laser microsurgery

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The prognostic value of p53 expression in negative surgical margins of early glottic carcinoma in the prediction of local recurrences

Cited by 4 publications

References 15 publications

Research Progress Regarding Surgical Margins, Molecular Margins, and Prognosis of Laryngeal Carcinoma

Research Progress Regarding Surgical Margins, Molecular Margins, and Prognosis of Laryngeal Carcinoma

Prevalence and Prognostic Value of HPV among Tunisian Patients with Laryngeal Cancer and Relationship between DNA HPV and p16, IGF-1R, Survivin, p53 Expressions

Risk factors for local recurrence of early bilateral vocal cord carcinoma treated with transoral CO2 laser microsurgery

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Risk factors for local recurrence of early bilateral vocal cord carcinoma treated with transoral CO₂ laser microsurgery