The prognostic value of peripheral blood parameters on all-frequency sudden sensorineural hearing loss

Sun, Haitao; Jiang, Wenbo; Wang, Jian

doi:10.1016/j.bjorl.2023.101302

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Moreover, they suggested that hyperfibrinogenemia may not be directly related to the cause of SSHL, but rather to the severity of the disease. Also, Sun et al [21] in 2023 found that blood fibrinogen level is a reliable indicator of the prognosis of SSHL when all frequencies are affected. In addition, recent studies have confirmed that thrombosis occurring in the inner ear can lead to a reduction in blood flow.…”

Section: Fibrinogenmentioning

confidence: 99%

The Role of Fibrinogen, Homocysteine and Metabolic Syndrome’s Alterations in Sudden Sensorineural Hearing Loss (SSHL): A Narrative Review

Monzani,

Liberale,

Segato

et al. 2023

Medicina

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Fibrinogen and homocysteine (HCY) are molecules known to play a role in vascular homeostasis, and their blood levels are often elevated in patients with metabolic syndrome. Recent evidence suggests that sudden sensorineural hearing loss (SSHL) may have a vascular origin. This has led many authors to advocate that fibrinogen, homocysteine, and metabolic syndrome (MetS) may play a direct role in SSHL. The aim of this brief review is to examine the role and influence of these molecules and MetS on the mechanisms of SSHL. Elevated fibrinogen levels have been associated with a worse prognosis in SSHL, possibly due to increased blood viscosity and decreased blood flow. Similarly, HCY has been associated with vascular damage, particularly in hyperhomocysteinemia, although the exact association with SSHL remains controversial. MetS has been demonstrated to function both as a causative factor and as a contributor to poorer recovery in cases of SSHL. However, although some studies suggest a possible role for these biomarkers and MetS in the prognosis and treatment of SSHL, specific therapeutic and preventive strategies based solely on these factors have yet to be developed. Given their potential role in prognosis and treatment and the global epidemic of metabolic syndrome, this issue needs to be analyzed comprehensively. Thus, further quality studies need to be conducted, even though it is difficult to determine the actual impact of MetS on the development of SSHL, as it is a multifactorial disease affecting multiple organs.

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Section: Fibrinogenmentioning

confidence: 99%

The Role of Fibrinogen, Homocysteine and Metabolic Syndrome’s Alterations in Sudden Sensorineural Hearing Loss (SSHL): A Narrative Review

Monzani,

Liberale,

Segato

et al. 2023

Medicina

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The Relationship between Sudden Sensorineural Hearing Loss and Serum Sex Hormone Levels in Perimenopausal Women

Wang,

Zhang

et al. 2024

Clin. Exp. Obstet. Gynecol.

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Background: The purpose of the study was to explore the relationship between sudden sensorineural hearing loss (SSNHL) and serum sex hormone levels in perimenopausal women, as well as to further investigate the influence of these indicators for SSNHL in perimenopausal women. Methods: A total of 156 patients with SSNHL and 149 healthy individuals during perimenopause who received treatment or underwent physical examination in the Fourth Hospital of Shijiazhuang from August 2023 to December 2023 were selected to participate in this retrospective cohort study. The variances in fundamental patient data were analyzed using the Mann-Whitney U test and Chi-square test. We employed multivariate logistic regression to examine the association between serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T), prolactin (PRL) levels and the occurrence of SSNHL in perimenopausal women. Spearman analysis was used to analyze the correlation between perimenopausal women serum sex hormone levels and SSNH. Results: Compared to the non SSNHL group, the SSNHL group women had lower serum levels of E2 and P ((35.08 ± 12.49) pmoL/L and (0.63 ± 0.24) nmoL/L) vs. ((43.46 ± 10.17) pmoL/L and (0.84 ± 0.13) nmoL/L) (p < 0.05). Multiple logistic regression analysis demonstrated that E2 and P were both at higher risk with the development of SSNHL. Spearman correlation analysis found that E2 and P are negatively correlated with pure tone hearing threshold in perimenopausal women. Conclusions: SSNHL in perimenopausal women may be related to their serum levels of sex hormones.

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The prognostic value of peripheral blood parameters on all-frequency sudden sensorineural hearing loss

Cited by 2 publications

References 21 publications

The Role of Fibrinogen, Homocysteine and Metabolic Syndrome’s Alterations in Sudden Sensorineural Hearing Loss (SSHL): A Narrative Review

The Role of Fibrinogen, Homocysteine and Metabolic Syndrome’s Alterations in Sudden Sensorineural Hearing Loss (SSHL): A Narrative Review

The Relationship between Sudden Sensorineural Hearing Loss and Serum Sex Hormone Levels in Perimenopausal Women

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