The prognostic value of peritoneal cytology in gynecologic malignant disease

Creasman, William T.; Rutledge, Felix N.

doi:10.1016/0002-9378(71)90571-0

Cited by 171 publications

(71 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through the designation as Stage IV disease [6,13] and the well-established associated poor prognosis [4,5], patients with IFCCs have traditionally been offered palliative care [7,16]. However, some groups suggest that the prognosis of patients with positive IFCCs can be improved through early identification and treatment.…”

Section: Implications Of Ifccs In Treatmentmentioning

confidence: 99%

“…The identification of IFCCs in gastric cancer patients has been used to predict the risk of peritoneal cancer recurrence and predict overall survival [1][2][3]. Patients with IFCCs have a poorer prognosis compared to those with no IFCCs [4,5].With peritoneal dissemination being the most common pattern of metastasis and recurrence in gastric carcinoma, the identification of IFCCs seems prudent [1]. To this end, the most recent TNM classification has included IFCC detection as part of the staging process, denoting M1 disease [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

et al. 2011

View full text Add to dashboard Cite

Background There is lack of uniformity in the utilization of peritoneal cytology in gastric cancer management. The identification of intraperitoneal free cancer cells (IFCCs) is believed to confer poor prognosis. However, while some of these patients are palliated, others may undergo more aggressive therapies. In this review, we aimed to identify and synthesize findings on the use of peritoneal cytology in predicting peritoneal recurrence and overall survival in curative gastric cancer patients. Methods Electronic literature searches were conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 31, 2009. We determined the accuracy, sensitivity, and specificity of peritoneal cytology in predicting peritoneal recurrence based on four techniques-conventional cytology, immunoassay, immunohistochemistry, and reverse transcriptase-polymerase chain reaction. Recurrence rates and overall survival rates for curative patients were determined, based on positivity or negativity for IFCCs. Results Twenty-eight articles were included. All four techniques showed wide variations in accuracy, sensitivity, and specificity in predicting peritoneal recurrence. Recurrence rates for patients positive for IFCCs ranged from 11.1 to 100%, while those negative for IFCCs had recurrence rates of 0-51%. Overall survival was significantly reduced for patients with positive IFCCs. Short follow-up periods and possible duplication of results may limit result interpretation. Conclusion The presence of IFCCs appears to increase the risk of peritoneal recurrence and is associated with worse overall survival in gastric cancer patients. Further incorporation of peritoneal cytology in clinical decisionmaking in gastric cancer depends on the development of a consistently accurate and rapid IFCC detection method.

show abstract

Section: Implications Of Ifccs In Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Furthermore, they demonstrated worse survival at 4 years for patients with positive washings as compared to their counterparts with negative washings. 20 The adverse impact of positive washings on overall survival was maintained even in patients with carcinoma that was limited to the endometrium and/or myometrium. 20 Numerous studies have since been published on the prognostic significance of positive washings in endometrial carcinoma, with contradicting results.…”

mentioning

confidence: 99%

“…20 The adverse impact of positive washings on overall survival was maintained even in patients with carcinoma that was limited to the endometrium and/or myometrium. 20 Numerous studies have since been published on the prognostic significance of positive washings in endometrial carcinoma, with contradicting results. The incidence of positive washings in clinical stage I endometrial carcinoma in these studies ranged from less than 3% to almost 30%, a level of discrepancy which is illustrative of the overall lack of consensus on this subject.…”

mentioning

confidence: 99%

“…In patients with endometrial cancers, the prognostic value of peritoneal washings was initially investigated in detail by Creasman and Rutledge in 1971. 20 Using a cohort of 183 patients who all received preoperative radiotherapy, the authors reported an incidence of positive washings of 11.5%. Furthermore, they demonstrated worse survival at 4 years for patients with positive washings as compared to their counterparts with negative washings.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Upstaging based solely on positive peritoneal washing does not affect outcome in endometrial cancer

et al. 2005

View full text Add to dashboard Cite

Surgical staging of endometrial carcinoma includes the collection of peritoneal washings in the abdomen and pelvis. A positive finding upstages patients to International Federation of Gynecology and Obstetrics stage IIIA. However, the prognostic significance of such an upstaging, and thus the justification for the routine performance of this procedure, is unclear. This 5-year retrospective study was conducted to determine the frequency and prognostic significance of upstaging of endometrial carcinoma based solely on positive washings. The cohort for the study was collected by review of pathology reports of all washings that were performed prior to hysterectomies for suspected endometrial carcinomas over a 5-year period (01/1995-12/ 1999). Cases with positive cytology were selected if there was no grossly apparent intraperitoneal disease, no histologic evidence of extra-uterine tumor and the cases would otherwise have been considered stage I or II (case group). An age-matched control group was selected of stage I and II patients with the same histologic subtypes and negative washings (n ¼ 19). Of 220 endometrial carcinomas, peritoneal washing cytology was abnormal in 19 (8.6%) and was solely responsible for upstaging only 10 patients (4.5% of all cases, eightendometrioid, one-serous, one-mixed; nine stage IA or IB and one stage IIB). Adjuvant therapy was administered in 90% of the case group and 74% of the control group. After a median follow-up of 51 months (case group) and 63 months (control group), we found only a single patient with progression of disease (recurrence, metastases or death) in the control group. It is concluded that abnormal cytology without other evidence of extrauterine disease leads to upstaging of a minority of endometrial carcinoma patients (4.5%), but does not appear to affect their overall outcome. Although this is a small single site study, it raises questions about the value of this procedure in patients with endometrial cancer.

show abstract

Implications of Peritoneal Cytology for Pancreatic Cancer Management

Makary¹

1998

Arch Surg

View full text Add to dashboard Cite

show abstract

The prognostic value of peritoneal cytology in gynecologic malignant disease

Cited by 171 publications

References 3 publications

A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

Upstaging based solely on positive peritoneal washing does not affect outcome in endometrial cancer

Implications of Peritoneal Cytology for Pancreatic Cancer Management

Contact Info

Product

Resources

About