The prognostic value of S-100 protein and Ki-67 index in olfactory neuroblastoma

Abstract

Objective To evaluate the prognostic value of S-100 protein and Ki-67 labeling index in olfactory neuroblastomas. Methods A retrospective study was conducted on a cohort of 85 patients with olfactory neuroblastomas. The immunohistochemical expression of S-100 and Ki-67 was assessed, and the predictive value of S-100 and Ki-67 was further evaluated. The optimal cutoff value of Ki-67 labeling index was determined using time-dependent receiver operating characteristic curve analysis. Overall survival and progression-free survival were assessed using the Kaplan–Meier method. Results A cut-off Ki-67 labeling index value of 67.5% was determined for prognosis in patients with olfactory neuroblastomas. There was a significant correlation between Ki-67 expression and cervical lymph node metastasis (P = 0.049). Compared with S-100 (+), S-100 (−) was associated with a higher rate of lymph node metastasis and a higher level of Ki-67 (P = 0.007, < 0.001, respectively), as well as an advanced Kadish stage (P = 0.037). Survival analyses showed that patients with S-100 (+) had better 5-year overall survival than those with S-100 (−) (P = 0.028), and patients with both S-100 (+) and Ki-67 (<67.5%) had superior 5-year overall survival compared with all the other patients (P = 0.0225). Conclusion Our findings suggest that S-100 combined with Ki-67 labeling index are reliable prognostic factors in patients with olfactory neuroblastomas.

Clinicopathological and Prognostic Significance of Platelet to Lymphocyte Ratio in Diffuse Large B-Cell Lymphoma: A Meta-Analysis

“…Of the 986 studies found, 11 were included because they satisfied the study's inclusion requirements (between January 2015 and December 2019) [11][12][13][14][15][16][17][18][19][20][21] . In the 11 articles, there were 2284 cases of DLBL.…”

“…Variable results were found when the PLR was examined for the prognosis of patients with DLBL. In patients with DLBL, the PLR has been shown to be predictive, though the results have been mixed [11][12][13][14][15][16][17][18][19][20][21] . We found a higher risk of inadequate overall survival and PFS associated with a high PLR based on 11 studies involving 2284 patients with DLBL [11][12][13][14][15][16][17][18][19][20][21] .…”

“…In patients with DLBL, the PLR has been shown to be predictive, though the results have been mixed [11][12][13][14][15][16][17][18][19][20][21] . We found a higher risk of inadequate overall survival and PFS associated with a high PLR based on 11 studies involving 2284 patients with DLBL [11][12][13][14][15][16][17][18][19][20][21] . According to the statistics, DLBL patients with a high PLR often had poor overall and PFS [28][29][30] .…”

“…The PLR is a prognostic indicator for a number of cancers, including ovarian cancer 7 , esophageal cancer 8 , DLBL 9 , and head and neck squamous cell carcinoma 10 . Despite the fact that a number of recent retrospective studies found a predictive role for the PLR in DLBL, their results were erratic and conflicting [11][12][13][14][15][16][17][18][19][20][21] .…”