The prognostic value of sarcopenia combined with preoperative fibrinogen–albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study

Abstract

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Preoperative Assessment of Skeletal Muscle Mass and Muscle Quality Using Computed Tomography: Incidence of Sarcopenia in Patients with Intrahepatic Cholangiocarcinoma Selected for Liver Resection

“…The authors concluded that their index, which can be preoperatively used, could represent a useful tool for risk classification and for clinical therapeutic decision-making for ICC patients [ 4 ]. A similar experience was reported by Yu [ 10 ], who showed that patients with high fibrinogen–albumin ratios and incidence of sarcopenia, had shorter overall survival and recurrence-free survival than other patients.…”

“…However, most of these studies come from Eastern hepatobiliary surgery centers [ 6 , 8 , 9 , 10 , 18 , 19 ]. The aim of our study was to retrospectively evaluate the incidence of sarcopenia in patients with ICC who were highly selected for liver resection at our Western center.…”

“…In 2013, Dodson and colleagues published the first experience in the literature that describes sarcopenia as an independent predictor of mortality following intra-arterial therapy for ICC [ 7 ]. After that, several papers reported the relation among sarcopenia, worse surgical outcomes, and poor oncological results in terms of disease-free and overall survival [ 6 , 8 , 9 , 10 , 11 ].…”

Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection

“…An increasing number of studies have shown that skeletal muscle loss (sarcopenia) is an indicator of poor prognosis in cancer patients (17,(20)(21)(22). However, in previous studies, researchers often focused on the skeletal muscle mass (17,(20)(21)(22), such as CT plane measurement of skeletal…”

“…(II) LABORATORY parameters, including carbohydrate antigen 19-9 (CA19-9), serum triglyceride, albumin, lymphocyte absolute value, neutrophil absolute value, high-density lipoprotein (HDL), and total bilirubin. Using laboratory parameters we calculated the prognostic nutritional index (PNI) and the fibrinogen albumin ratio (FAR), which were considered to be associated with the prognosis of numerous tumor patients (17)(18)(19)(20). (III) Pathological parameters, including TNM stage (AJCC 8 th ) and tumor differentiation.…”