The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans

Mapoure, Yacouba Njankouo; Ayeah, Chia Mark; Hamadou, Bâ; Hentchoya, Romuald; Luma, Henry Namme

doi:10.1016/j.jstrokecerebrovasdis.2017.10.006

Cited by 16 publications

(10 citation statements)

References 33 publications

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“…Weir et al studied around 2500 stroke survivors, indicating that the addition of 1.7 mg/dl in urate level was associated with an increased risk of stroke by 27% anticipating a worse outcome and increased chances of repeated stroke [26]. More recently, the analysis by Mapoure et al confirmed the earlier results by reporting that higher serum uric acid quintile ranges (SUA 71-84 mg/L and SUA > 85 mg/L) had more proportion of deaths and were statistically more likely to correspond with poorer outcomes [27]. However, a series of interesting results were also found in three studies where no conclusive relation could be identified between the outcome of stroke and uric acid levels [7,28,29].…”

Section: Reviewmentioning

confidence: 96%

“…Similarly, Wang et al reported that high serum uric acid levels at hospital admission were especially protective in men [23]. Four of studies reported data of poor outcome after stroke due to increase serum uric acid levels [24-27]. Weir et al studied around 2500 stroke survivors, indicating that the addition of 1.7 mg/dl in urate level was associated with an increased risk of stroke by 27% anticipating a worse outcome and increased chances of repeated stroke [26].…”

Section: Reviewmentioning

confidence: 99%

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Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes

Tariq¹,

Shamim²,

Rana³

et al. 2019

Cureus

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Over the last decades several studies among the adult population have attempted to establish a correlation between the risk of stroke incidence and serum uric acid (SUA) concentration, and how these levels influence the patient's neurological outcome after a stroke. But, to date, the results are conflicting. In this review, an extensive literature search was performed through PubMed for articles published until May 2019 to review the association. The study selection was narrowed by searching PubMed database using the Medical Subject Headings (MesH) and associated keywords. Only articles conducted in English and on human subjects were included. We considered an article for this review if it had statistics on either the incidence, stroke mortality or post-stroke functional outcomes along with serum uric acid levels in adults. This review includes 21 articles with data of 33,580 cases of stroke and 1,100,888 participants. We can divide the articles reviewed into two separate cohorts of studies. One relates serum uric acid levels to stroke frequency and mortality, while the other is associated with serum uric acid and outcomes for stroke survivors. Based on our review, no significant relationship is observed with uric acid exhibiting protective effects on stroke outcome. Large clinical trials are advised to provide well-defined solutions to further assess the benefits of uric acid level lowering treatment in patients of vascular events, such as a stroke. However, we confidently report that increasing uric acid levels poses a higher risk for incidence of stroke.

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Section: Reviewmentioning

confidence: 96%

Section: Reviewmentioning

confidence: 99%

Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes

Tariq¹,

Shamim²,

Rana³

et al. 2019

Cureus

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“…Some studies reported that high SUA levels were a protective factor for functional outcomes, [18][19][20] while some studies reported that SUA levels were a risk factor. [21][22][23] Recently, Wang et al 28 conducted a metaanalysis that included 10 studies with a total of 8131 patients with acute ischaemic stroke to address this issue. They showed that high SUA levels were significantly associated with a better outcome after acute ischaemic stroke (hazard ratio ¼ 0.77, 95% CI 0.68-0.88, P ¼ 0.0001).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies showed that patients with high SUA levels had improved survival and good functional outcomes, [18][19][20] whereas some other studies reported that high SUA levels were associated with a worse outcome. [21][22][23] Furthermore, Miedema et al 24 reported that there was no association between SUA levels and prognostic outcome in acute ischaemic stroke. Therefore, the effect of SUA levels on prognostic outcome still requires further investigation.…”

Section: Introductionmentioning

confidence: 99%

High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke

Sun

Lai

et al. 2018

J Int Med Res

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ObjectiveWe aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke.MethodsWe retrospectively analysed the outcomes of 1166 patients with ischaemic stroke who were hospitalized in our centre during August 2008 to November 2012. Correlations of serum uric acid levels and prognostic outcomes were analysed.ResultsMen had higher serum uric acid levels and better neurological functional outcomes compared with women. There was a strong negative correlation between serum uric acid levels and unfavourable neurological functional outcomes. Generalized estimated equation analysis showed that a higher serum uric acid level (>237 µmol/L) was a protective factor for neurological functional outcome in male, but not female, patients. Among five trial of ORG 10172 in acute stroke treatment classification subtypes, only patients with the large-artery atherosclerosis subtype had a significant protective effect of serum uric acid levels on neurological outcome.ConclusionsOur study shows that high serum uric acid levels are a significant protective factor in men and in the large-artery atherosclerosis subtype in patients with ischaemic stroke. This is helpful for determining the prognostic value of serum uric acid levels for neurological outcome of acute ischaemic stroke.

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“…On the contrary, as an oxidant, high SUA is associated with hypertension, atherosclerosis, metabolic diseases, and cerebrovascular stenosis (Patetsios et al, 2001 ; Masi et al, 2019 ). Furthermore, poorer prognosis is associated with very low and very high concentrations of SUA in patients with AIS (Mapoure et al, 2018 ). Although a U-shaped relationship between SUA and functional outcomes was found in AIS, the specific mechanism is still unclear.…”

Section: Introductionmentioning

confidence: 99%

The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke

et al. 2021

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Objective: The U-shaped association between serum uric acid (SUA) and the functional outcome has been found in acute ischemic stroke (AIS). However, it is unclear if SUA is associated with red blood cell morphology in AIS. This study aimed to determine the relationship between SUA and red blood cell distribution width (RDW) in patients with AIS.Methods: A cross-sectional study including 438 consecutive patients with AIS was conducted. SUA and RDW, biochemical parameters that reflect the heterogeneity of red blood cell volume, were evaluated on admission. We evaluated the association between SUA and RDW through linear curve fitting analyses and two-piecewise regression analyses.Results: The association between SUA levels and RDW followed a U-shape in all patients. In females, the values of RDW significantly decreased with the increment of SUA (per mg/dl: β, −1.45; 95% CI: −2.15 to −0.75; p < 0.001) in patients with SUA <3.86 mg/dl and increased with the increment of SUA (per mg/dl: β, 0.60; 95% CI: 0.22–0.97; p = 0.002) in patients with SUA ≥ 3.86 mg/dl. Similar results were observed in males with the turning point of SUA = 4.82 mg/dl. After adjusting for potential confounders, a U-shaped association between SUA and RDW was maintained in females, but no statistical significance was maintained in patients with SUA ≥ 4.82 mg/dl in males (p = 0.206).Conclusion: In the sample of patients with AIS, we found a U-shaped relationship between SUA levels and RDW, with the turning point of SUA (3.96 mg/dl in females and 4.82 mg/dl in males) by the threshold effect analysis.

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The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans

Cited by 16 publications

References 33 publications

Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes

Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes

High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke

The U-Shaped Association Between Serum Uric Acid and Red Blood Cell Distribution Width in Acute Ischemic Stroke

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