The prognostic value of the advanced lung cancer inflammation index in patients with gastrointestinal malignancy

Zhang, Lilong; Zhao, Kailiang; Kuang, Tianrui; Wang, Kunpeng; Chai, Dongqi; Qiu, Zhendong; Liu, Rongqiang; Deng, Wenhong; Wang, Weixing

doi:10.1186/s12885-023-10570-6

Cited by 7 publications

(1 citation statement)

References 40 publications

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“…Patients with low ALI have more adverse events. 16 , 19 , 20 Therefore, T3 was selected as a reference. Model 1 consisted of only the ALI index, and the results were as follows: T1 vs T3: HR: 3.221, (95% CI:1.514–6.853), p=0.002 and T2 vs T3: HR: 2.255 (95% CI: 1.027–4.952), p=0.043.…”

Section: Resultsmentioning

confidence: 99%

Advanced Lung Cancer Inflammation Index for Predicting Prognostic Risk for Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Wang,

Wei,

Fan

et al. 2023

JIR

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Purpose The decreased advanced lung cancer inflammation index (ALI), defined as body mass index (BMI) * albumin (Alb)/neutrophil-to-lymphocyte ratio (NLR), is an independent prognostic risk factor for overall survival in gastric, lung, and colorectal cancers. This study aimed to investigate the value of ALI in predicting the risk of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS). Patients and Methods A total of 1624 patients with ACS undergoing percutaneous coronary intervention (PCI) were consecutively enrolled between January 2016 and December 2018. Follow-up data were collected at 1, 3, 6, and 12 months and annually thereafter. The primary endpoints were MACEs. All endpoints were defined as all-cause mortality, recurrent angina pectoris, restenosis/intra stent thrombosis, stroke, heart failure, and all-cause bleeding. Results The MACEs group and non-MACEs group showed significant differences in patients with age >65 years (28 [50.0%] vs 319 [23.7%]), history of heart failure (16 [28.6%] vs 127 [9.4%]), history of ischemic stroke (14 [25.0%] vs 186 [13.8%]), history of cardiogenic shock (6 [10.71%] vs 16 [1.19%]), left ventricular ejection fraction <40% (8 [14.29%] vs 33 [2.46%]), and ALI <343.96 (44 [78.65%] vs 680 [50.60%]) (all p<0.001). The optimal cut-off value for ALI was 334.96. The area under the curve (AUC) of the 1-, 2-, 3-, and 5-year was 0.560, 0.577, 0.665, and 0.749, respectively. The survival rate was significantly lower in the low ALI group than in the high ALI group (log-rank p<0.001). Low ALI was an independent risk factor for the long-term prognosis of patients with ACS after PCI, univariate HR: 3.671, 95% CI: 1.938–6.953, p<0.001; multivariate HR: 3.009, 95% CI: 1.57–5.769, p=0.001. Conclusion ALI score less than 334.96 is an independent prognostic risk factor for patients with ACS undergoing PCI and may be a novel marker for clinical practice.

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Section: Resultsmentioning

confidence: 99%

Advanced Lung Cancer Inflammation Index for Predicting Prognostic Risk for Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Wang,

Wei,

Fan

et al. 2023

JIR

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Routine perioperative blood tests predict survival of resectable lung cancer

Morelli,

Cantarutti,

Valsecchi

et al. 2023

Sci Rep

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There is growing evidence that inflammatory, immunologic, and metabolic status is associated with cancer patients survival. Here, we built a simple algorithm to predict lung cancer outcome. Perioperative routine blood tests (RBT) of a cohort of patients with resectable primary lung cancer (LC) were analysed. Inflammatory, immunologic, and metabolic profiles were used to create a single algorithm (RBT index) predicting LC survival. A concurrent cohort of patients with resectable lung metastases (LM) was used to validate the RBT index. Charts of 2088 consecutive LC and 1129 LM patients undergoing lung resection were evaluated. Among RBT parameters, C-reactive protein (CRP), lymphocytes, neutrophils, hemoglobin, albumin and glycemia independently correlated with survival, and were used to build the RBT index. Patients with a high RBT index had a higher 5-year mortality than low RBT patients (adjusted HR 1.93, 95% CI 1.62–2.31). High RBT patients also showed a fourfold higher risk of 30-day postoperative mortality (2.3% vs. 0.5%, p 0.0019). The LM analysis validated the results of the LC cohort. We developed a simple and easily available multifunctional tool predicting short-term and long-term survival of curatively resected LC and LM. Prospective external validation of RBT index is warranted.

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Neutrophil-To-Lymphocyte Ratio as a Prognostic Indicator in Thyroid Cancer

Gao,

Quan,

Zhang

et al. 2024

Cancer Control

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Objective In this study, we aimed to perform a comprehensive analysis to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR) levels in patients diagnosed with thyroid cancer. Methods We systematically searched multiple databases, including PubMed, the Cochrane Library, EMBASE, and Google Scholar, up until March 30, 2023, to identify relevant articles. The clinical outcomes evaluated in this study included overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), and cause-specific survival (CSS). Results This analysis includes 21 articles with 5187 patients in total. The pooled results revealed that patients with high NLR levels had significantly poorer OS (HR: 2.578, 95% CI: 2.050-3.242, P < 0.001), PFS (HR: 2.143, 95% CI: 1.616-2.843, P < 0.001), DFS (HR: 1.377, 95% CI: 1.045-1.816, P = 0.023), and CSS (HR: 2.842, 95% CI: 1.334-6.053, P = 0.007). The subgroup analyses were performed based on different study regions, treatment modalities, cancer types, and NLR cut-off values, and the above conclusion remained consistent in the majority of subgroup analyses. The stability and reliability of the aforementioned results were supported by the sensitivity analysis and publication bias test. Conclusion The baseline NLR levels were useful predictors of outcomes in patients with thyroid cancer.

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The prognostic value of the advanced lung cancer inflammation index in patients with gastrointestinal malignancy

Cited by 7 publications

References 40 publications

Advanced Lung Cancer Inflammation Index for Predicting Prognostic Risk for Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Advanced Lung Cancer Inflammation Index for Predicting Prognostic Risk for Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Routine perioperative blood tests predict survival of resectable lung cancer

Neutrophil-To-Lymphocyte Ratio as a Prognostic Indicator in Thyroid Cancer

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