The Prognostic Value of the Derived Neutrophil-to-Lymphocyte Ratio in Transplantation-Ineligible Patients with Multiple Myeloma

Uz, Burak

doi:10.1159/000491988

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…The prognostic effects of dNLR in hematological malignancies have been recently reported. Elevated dNLR level was an independent poor prognostic factor for transplantation-ineligible MM patients with MM 41. Independent significant association between dNLR and poor OS as well as DFS was identified in DLBCL 15.…”

Section: Discussionmentioning

confidence: 83%

<p>Prognostic significance of peripheral blood absolute lymphocyte count and derived neutrophil to lymphocyte ratio in patients with newly diagnosed extranodal natural killer/T-cell lymphoma</p>

Zhou

Sun

Zhao

et al. 2019

CMAR

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Background: Accumulating evidence suggested that tumor microenvironment and host immune system played important roles in determining the clinical course and outcome of human malignancies. The derived neutrophil to lymphocyte ratio (dNLR) and absolute lymphocyte count (ALC) were demonstrated to act as a prognostic factor in several malignancies. Nevertheless, the prognostic significance of them in extranodal natural killer/T-cell lymphoma (ENKTL) patients has never been explored. Patients and methods: A total of 33 newly diagnosed patients with ENKTL were included in this study. Clinicopathological characteristics were collected and prognostic significance of dNLR and ALC were evaluated. Results: Elevated dNLR and low ALC were both associated with poor survival rates. Patients with dNLR ≥3.6 revealed significantly shorter overall survival (OS) ( P =0.001) and progression-free survival (PFS) ( P =0.008) than those with dNLR <3.6. Patients with ALC <0.8×10 9 /L had worse OS ( P =0.008) and PFS ( P <0.001) than those with ALC ≥0.8×10 9 /L. An independent significant association between low ALC and poor clinical outcome in multivariate analysis for OS (HR, 36.023; 95% CI, 2.438–532.243; P =0.009) as well as PFS (HR, 7.698; 95%CI, 1.573–37.679; P =0.012) was identified. Conclusion: In this study, we validated for the first time the prognostic value of dNLR and ALC in ENKTL patients. Elevated dNLR and low ALC were both associated with aggressive tumor process and poor survival.ALC value at diagnosis represented an independent favorable prognostic factor for the clinical outcome of ENKTL patients.

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Section: Discussionmentioning

confidence: 83%

<p>Prognostic significance of peripheral blood absolute lymphocyte count and derived neutrophil to lymphocyte ratio in patients with newly diagnosed extranodal natural killer/T-cell lymphoma</p>

Zhou

Sun

Zhao

et al. 2019

CMAR

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“…Our study also identified a potential prognostic value of NLR in PCNSL, although the result was then not confirmed by multivariate analysis. Elevated dNLR level is an independent poor prognostic parameter in patients with multiple myeloma who are not suitable for transplantation ( 29 ). In DLBCL, an independent and significant correlation between dNLR and poor OS and DFS was reported ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

A Novel Prognostic Marker for Primary CNS Lymphoma: Lactate Dehydrogenase-to-Lymphocyte Ratio Improves Stratification of Patients Within the Low and Intermediate MSKCC Risk Groups

Gao

Kim

et al. 2021

Front. Oncol.

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BackgroundPrimary central nervous system lymphoma (PCNSL) is a highly aggressive and rare extranodal non-Hodgkin lymphoma (NHL). The MSKCC and the IELSG scores represent the most widely used prognostic models, but many changes have occurred in therapeutic protocols since their development. Moreover, many PCNSL patients cannot be classified using the IELSG score. We thus aimed to create a novel, effective and feasible prognostic model for PCNSL.MethodsWe included 248 PCNSL patients diagnosed with PCNSL. Our primary endpoint was the overall survival (OS) and we used the receiver operating characteristic (ROC) analysis to determine the optimal prognostic cut-off value for LLR (lactate dehydrogenase-to-lymphocyte ratio), neutrophil-to-lymphocyte ratio (NLR) and derived neutrophil-to-lymphocyte ratio (dNLR). Variable associated with OS were evaluated by univariate and multivariate analyses. 124 out of 248 patients were randomly selected as the internal validation cohort.ResultsBy univariate analysis, an age >60 years, Eastern Cooperative Oncology Group performance status (ECOG PS) >1, treatment with radiotherapy alone, high-risk groups of Memorial Sloan Kettering Cancer Center (MSKCC) score, NLR >4.74, dNLR >3.29, and LLR >166.8 were significantly associated with a worse OS. By multivariate analysis, the MSKCC score and LLR were confirmed as independent prognostic parameters for poorer OS. OS, however, was not significantly different between low- and intermediate-risk groups according to the MSKCC score, while LLR proved to be prognostically relevant and was thus used to develop a novel, effective three-tier PCNSL scoring system. Of 124 patients, 84 patients with survival data and LLR data were successfully validated by newly established PCNSL LLR scoring system.ConclusionsIn the present study, we demonstrate that a high LLR represents an independent unfavorable prognostic parameter in PCNSL patients which can be integrated into an effective prognostic model.

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“…In multivariate analysis, NLR was not an independent prognostic factor for poor survival of patients receiving bortezomib-based therapy; patients obtained lower 4-year OS rates with NLR > 2.95 compared to patients with NLR < 2.95 (30.9% vs. 64.8%). However, in a prior study involving 179 MM patients treated with the bortezomib-melphalanprednisone (VMP) regimen, multivariate analysis revealed that high NLR was an independent poor prognostic factor (14). In addition to the OS, it also has an indication of the treatment response to bortezomib.…”

Section: Neutrophil-to-lymphocyte Ratio (Nlr)mentioning

confidence: 99%

“…The complete response rate (CRR) was significantly inferior when comparing high-and low-NLR groups (7% vs. 26.1%). Based on the results of univariate logistic regression analysis, as well as multivariate analysis, high NLR was identified as a poor prognostic factor of CRR to bortezomib (14). In the last decade, ASCT has been widely used in treatment of MM patients.…”

Section: Neutrophil-to-lymphocyte Ratio (Nlr)mentioning

confidence: 99%

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Predictive Role of Immune Profiling for Survival of Multiple Myeloma Patients

Liu

2021

Front. Immunol.

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Despite new efficacy drugs and cell therapy have been used for multiple myeloma (MM) patients, some patients will relapse over time. We wonder the immune system play a vital role as well as MM cell during the development of disease. It is clear that the characteristic of myeloma cell is associated with the survival of MM patients. However, the link between the immune profiling and the prognosis of the disease is still not entirely clear. As more study focus on the role of immunity on multiple myeloma pathogenesis. There are plenty of study about the predictive role of immunity on the survival of multiple myeloma patients. Up to mow, the majority reviews published have focused on the immunotherapy and immune pathogenesis. It is indispensable to overlook the predictive role of immunity on multiple myeloma patients. Here, we give a review of vital previous works and recent progress related to the predictive role of immune profiling on multiple myeloma, such as absolute lymphocyte count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocytes and cytokines.

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The Prognostic Value of the Derived Neutrophil-to-Lymphocyte Ratio in Transplantation-Ineligible Patients with Multiple Myeloma

Cited by 8 publications

References 6 publications

<p>Prognostic significance of peripheral blood absolute lymphocyte count and derived neutrophil to lymphocyte ratio in patients with newly diagnosed extranodal natural killer/T-cell lymphoma</p>

<p>Prognostic significance of peripheral blood absolute lymphocyte count and derived neutrophil to lymphocyte ratio in patients with newly diagnosed extranodal natural killer/T-cell lymphoma</p>

A Novel Prognostic Marker for Primary CNS Lymphoma: Lactate Dehydrogenase-to-Lymphocyte Ratio Improves Stratification of Patients Within the Low and Intermediate MSKCC Risk Groups

Predictive Role of Immune Profiling for Survival of Multiple Myeloma Patients

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