The prognostic value of the electroencephalogram in premature infants

Tharp, Barry R.; Cukier, F; Monod, N

doi:10.1016/0013-4694(81)90136-x

Cited by 129 publications

(59 citation statements)

References 21 publications

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“…Pioneering studies have shown that the EEG provides valuable prognostic information in preterm infants [32,[43][44][45][46][47][48][49][50] , and this has been confirmed by other more recent studies [25,[51][52][53][54][55][56][57] .…”

Section: Introductionsupporting

confidence: 52%

EEG - A Valuable Biomarker of Brain Injury in Preterm Infants

Pavlidis¹,

Lloyd²,

Boylan³

2017

Dev Neurosci

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This review focuses on the role of electroencephalography (EEG) in monitoring abnormalities of preterm brain function. EEG features of the most common developmental brain injuries in preterm infants, including intraventricular haemorrhage, periventricular leukomalacia, and perinatal asphyxia, are described. We outline the most common EEG biomarkers associated with these injuries, namely seizures, positive rolandic sharp waves, EEG suppression/increased interburst intervals, mechanical delta brush activity, and other deformed EEG waveforms, asymmetries, and asynchronies. The increasing survival rate of preterm infants, in particular those that are very and extremely preterm, has led to a growing demand for a specific and shared characterization of the patterns related to adverse outcome in this unique population. This review includes abundant high-quality images of the EEG patterns seen in premature infants and will provide a valuable resource for everyone working in developmental neuroscience.

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Section: Introductionsupporting

confidence: 52%

EEG - A Valuable Biomarker of Brain Injury in Preterm Infants

Pavlidis¹,

Lloyd²,

Boylan³

2017

Dev Neurosci

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“…Electrographic seizure activity on conventional EEG has been recognized in the preterm infant in association with IVH (11) and adverse neurologic sequela (12). Epidemiologic data suggest that it is more common in infants of low birth weight (1,3).…”

Section: Discussionmentioning

confidence: 99%

Electrographic Seizures in Preterm Infants During the First Week of Life Are Associated With Cerebral Injury

et al. 2010

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ABSTRACT:The aim of the study was to determine the incidence of electrographic seizure activity in a prospective cohort of preterm infants and relate it to the presence of cerebral injury. Infants born Ͻ30-wk gestation received a median 74 h of continuous 2-channel EEG with amplitude-integrated EEG monitoring in the first week of life. Infants were classified in the abnormal outcome group if they died in the neonatal period and/or had grades 3-4 intraventricular hemorrhage and/or moderate or severe abnormalities on cerebral MRI. Seizures were defined as rhythmic spike and/or wave activity lasting at least 10 s on the raw EEG trace. Eleven of 51 infants monitored had electrographic seizures. These infants were more premature had lower birth weights and a greater proportion had abnormal outcomes. In four infants, seizures preceded ultrasound findings of grades 3-4 intraventricular hemorrhage. Three of the four infants with seizures and concurrent physiologic recordings displayed concurrent rises in heart rate and one showed a fall in respiratory rate. In conclusion, electrographic seizures were more likely to occur in the sicker and more premature infants with abnormal outcomes. Seizures detected on continuous amplitude-integrated EEG monitoring with the raw EEG were associated with poor outcome. (Pediatr Res 67: 102-106, 2010)

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“…This activity is characterized primarily by theta bursts and by delta brushes (i.e., intermittent 10-to 20-Hz activity superimposed on high-amplitude delta waves). These changes are accompanied by a steady decrease in the number and duration of periods of quiescence or discontinuity (Tharp et al, 1981;Werner et al, 1977). Distinctive EEG patterns which correlate well with behaviorally defined sleep state have been shown to exist in full-term and preterm human infants (Anders, Ende, & Parmelee, 1971;Scher et al, 1994;Stefanski et al, 1984;Werner et al, 1977) and many other species (Berger & Meier, 1965;Dawes, Fox, Leduc, Liggins, & Richards, 1972;Guthrie, Standaert, Hodson, & Woodrum, 1980;Jouvet-Mounier, Astic, & Lacote, 1970).…”

Section: Introductionmentioning

confidence: 97%

“…In preterm infants of less than 30 weeks gestation, EEG activity predominates in the central and midline regions of the brain, and is characterized by a mixture of fast and slow rhythms superimposed on a predominantly discontinuous background (Tharp, Cukier, & Monod, 1981;Werner, Stockard, & Bickford, 1977). After 30 weeks gestational age, there is an increase in temporal lobe activity and a more-continuous background emerges.…”

Section: Introductionmentioning

confidence: 99%