The prognostic value of toll-like receptor5 and programmed cell death-ligand1 in patients with peripheral T-cell non-Hodgkin lymphoma

Sun, Mengqi; Su, Wen; Qian, Jingrong; Meng, Hongxue; Ji, Hongfei; Liu, Yupeng; Zhang, Yue; Li, Wenhui; Zhang, Qingyuan; Song, Zhao

doi:10.1080/10428194.2019.1602266

Cited by 6 publications

(7 citation statements)

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“…Sun et al reported that the presence of the high PD-L1+ group (46%) including PD-L1+ tumour cells, resulted in significantly poorer prognosis compared with presence of the low PD-L1+ group (54%) in 144 patients with AITL, PTCL-NOS, ALK+ and ALK− sALCL ( p < 0.05) [ 18 ]. However, PD-L1+ tumour cells were frequently found in 34 of 45 ALK+ (76%) and 21 of 50 ALK− (42%) sALCL patients [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In T/natural killer (NK) cell neoplasia, PD-L1+ tumour cells were frequently found in anaplastic lymphoma kinase (ALK) + and ALK− systemic anaplastic large cell lymphoma (sALCL), occasionally in PTCL-NOS, and rarely in AITL [ 16 – 19 ]. Patients demonstrating combined PD-L1+ tumour cells and intense reaction of PD-L1+ non-neoplastic cells (high PD-L1+ group) showed significantly poorer prognosis compared with the low PD-L1+ group in the above four types of PTCLs [ 18 ]. The combination of PD-1+ tumour cells and high PD-L1+ group was related to shorter survival in AITL patients ( p = 0.051), but not PTCL-NOS [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers

et al. 2021

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Background The clinicopathological characteristics and prognostic factors in nodal peripheral T-cell lymphomas (PTCLs) with two or more T follicular helper markers (TFH+) are not adequately investigated. Methods Immunohistologically, we selected 22 patients with TFH+ lymphoma (PTCL-TFH) in 47 of PTCL-not otherwise specified (NOS), and subclassified into large and small cell groups. We compared the two groups with 39 angioimmunoblastic T-cell lymphoma (AITL) and seven follicular T-cell lymphoma (F-TCL) patients. Prognostic factors were analysed by overall survival in patients with three types of TFH+ PTCLs. Results Thirteen large cell and nine small cell PTCL-TFH patients had more than two TFH markers including programmed cell death-1 (PD-1). Large cell PTCL-TFH showed frequent CMYC expression in 10 patients (77%), and four of 11 large cell group (36%) had somatic RHOA G17V gene mutation by Sanger sequencing. Large cell PTCL-TFH patients showed significantly worse prognosis than those of the small cell group, AITL, and F-TCL (p < 0.05). In TFH+ PTCLs, CMYC+ tumour cells, and combined PD-1 ligand 1 (PD-L1) + tumour cells and intense reaction of PD-L1+ non-neoplastic cells (high PD-L1+ cell group) were significantly poor prognostic factors (p < 0.05). Combinations of CMYC+ or PD-1+ tumour cells and high PD-L1+ cell group indicated significantly poor prognosis (p < 0.01). Conclusion Large cell PTCL-TFH indicated poor prognosis in TFH+ PTCLs. These data suggested that CMYC+ tumour cells and intense PD-L1+ cell reaction influenced tumour cell progression in TFH+ PTCLs, and PD-1+ tumour cell/intense PD-L1+ cell reactions may play a role in immune evasion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers

et al. 2021

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“…Sun et al reported that the presence of the high PD-L1 + group (45.8%) including PD-L1 + tumour cells, resulted in signi cantly poorer prognosis compared with presence of the low PD-L1 + group (54.2%) in 144 patients with AITL, PTCL-NOS, ALK + and ALK − sALCL (p < 0.05) [19]. However, PD-L1 + tumour cells were frequently found in 34 of 45 ALK+ (76%) and 21 of 50 ALK− (42%) sALCL patients [20].…”

Section: Discussionmentioning

confidence: 99%

“…Interactions between PD-1 and PD-L1 play a role in immune suppression during in ammatory processes, and PD-L1 expression induces an immune evasion mechanism exploited by various malignancies [1,16]. In T/natural killer (NK) cell neoplasia, PD-L1 + tumour cells were frequently found in anaplastic lymphoma kinase (ALK) + and ALK − systemic anaplastic large cell lymphoma (sALCL), occasionally in PTCL-NOS, and rarely in AITL [17][18][19][20]. Patients demonstrating combined PD-L1 + tumour cells and intense reaction of PD-L1 + non-neoplastic cells (high PD-L1 + group) showed signi cantly poorer prognosis compared with the low PD-L1 + group in the above four types of PTCL [19].…”

Section: Introductionmentioning

confidence: 99%

“…In T/natural killer (NK) cell neoplasia, PD-L1 + tumour cells were frequently found in anaplastic lymphoma kinase (ALK) + and ALK − systemic anaplastic large cell lymphoma (sALCL), occasionally in PTCL-NOS, and rarely in AITL [17][18][19][20]. Patients demonstrating combined PD-L1 + tumour cells and intense reaction of PD-L1 + non-neoplastic cells (high PD-L1 + group) showed signi cantly poorer prognosis compared with the low PD-L1 + group in the above four types of PTCL [19]. The combination of PD-1 + tumour cells and high PD-L1 + group was related to shorter survival in AITL patients (p = 0.051), but not PTCL-NOS [21].…”

Section: Introductionmentioning

confidence: 99%

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Large tumour cell group, combinations of CMYC+ or PD-1+ tumour cells and intense PD-L1+ cell reaction are important prognostic factors in nodal T-cell lymphomas with T follicular helper markers

Mihashi

Kimura

Iwasaki

et al. 2021

Preprint

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Background The clinicopathological characteristics and prognostic factors in nodal T-cell lymphomas with T follicular helper markers (TFH+) are not adequately investigated. Methods Immunohistologically, we selected 22 patients with TFH + lymphoma in 47 of peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS), and subclassified into large and small cell groups. We compared the two groups with 39 angioimmunoblastic T-cell lymphoma (AITL) and seven follicular T-cell lymphoma (F-TCL) patients. Prognostic factors were analysed by overall survival in patients with three types of TFH + lymphomas. Results Thirteen large cell and nine small cell PTCL patients had more than two TFH markers including programmed cell death-1 (PD-1). Large cell TFH + PTCL showed CMYC expression in 10 patients (76.9%), and four of 11 large cell group (36.4%) had somatic RHOA G17V gene mutation by Sanger sequencing. In TFH + lymphomas, large cell TFH + PTCL patients showed significantly worse prognosis than those of the small cell group, AITL, and F-TCL (p < 0.05). CMYC + tumour cells, and combined PD-1 ligand 1 (PD-L1) + tumour cells and intense reaction of PD-L1 + non-neoplastic cells (high PD-L1 + cell group) were significantly poor prognostic factors (p < 0.05). Combinations of CMYC + or PD-1 + tumour cells and high PD-L1 + cell group indicated significantly poor prognosis (p < 0.01). Conclusion Large cell TFH + PTCL indicated poor prognosis in TFH + lymphomas. These data suggested that CMYC + tumour cells and intense PD-L1 + cell reaction influenced tumour cell progression in TFH + lymphomas, and PD-1 + tumour cell/intense PD-L1 + cell reactions may play a role in immune evasion.

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Prognosis and risk stratification of peripheral T-cell lymphomas

Malecek

Mehta‐Shah

2021

Seminars in Hematology

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The prognostic value of toll-like receptor5 and programmed cell death-ligand1 in patients with peripheral T-cell non-Hodgkin lymphoma

Cited by 6 publications

References 31 publications

Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers

Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers

Large tumour cell group, combinations of CMYC+ or PD-1+ tumour cells and intense PD-L1+ cell reaction are important prognostic factors in nodal T-cell lymphomas with T follicular helper markers

Prognosis and risk stratification of peripheral T-cell lymphomas

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